ID O21449 PRELIMINARY; PRT; 160 AA. AC O21449; DT 01-JAN-1998 (TrEMBLrel. 05, Created) DT 01-JAN-1998 (TrEMBLrel. 05, Last sequence update) DT 01-MAR-2002 (TrEMBLrel. 20, Last annotation update) DE CYTOCHROME C OXIDASE POLYPEPTIDE I (EC 1.9.3.1) (FRAGMENT). GN MT:COI OR COI. OS Drosophila pseudoobscura bogotana (Fruit fly). OG Mitochondrion. OC Eukaryota; Metazoa; Arthropoda; Tracheata; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=46244; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=BOGOTA; RA Gleason J.M., Caccone A., Moriyama E.N., Powell J.R.; RL Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: CYTOCHROME C OXIDASE IS THE COMPONENT OF THE RESPIRATORY CC CHAIN THAT CATALYZES THE REDUCTION OF OXYGEN TO WATER. SUBUNITS 1- CC 3 FORM THE FUNCTIONAL CORE OF THE ENZYME COMPLEX. CO I IS THE CC CATALYTIC SUBUNIT OF THE ENZYME. ELECTRONS ORIGINATING IN CC CYTOCHROME C ARE TRANSFERRED VIA THE COPPER A CENTER OF SUBUNIT 2 CC AND HEME A OF SUBUNIT 1 TO THE BIMETALLIC CENTER FORMED BY HEME A3 CC AND COPPER B (BY SIMILARITY). CC -!- CATALYTIC ACTIVITY: 4 FERROCYTOCHROME C + O(2) = 4 FERRICYTOCHROME CC C + 2 H(2)O. CC -!- COFACTOR: HEMES A, A3, AND COPPER B (BY SIMILARITY). CC -!- PATHWAY: TERMINAL STEP IN THE RESPIRATORY CHAIN. CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. MITOCHONDRIAL CC INNER MEMBRANE (BY SIMILARITY). CC -!- SIMILARITY: BELONGS TO THE HEME-COPPER RESPIRATORY OXIDASE FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U51607; AAB68484.1; -. DR FlyBase; FBgn0021234; Dpsb\mt:CoI. DR InterPro; IPR000883; COX1. DR Pfam; PF00115; COX1; 1. DR PROSITE; PS00077; COX1; 1. KW Copper; Heme; Inner membrane; Mitochondrion; Oxidoreductase; KW Respiratory chain; Transmembrane. FT NON_TER 1 1 FT NON_TER 160 160 SQ SEQUENCE 160 AA; 17595 MW; 9ED35D4F54A6DB5B CRC64; QHLFWFFGHP EVYILILPGF GMISHIISQE SGKKETFGSL GMIYAMLAIG LLGFIVWAHH MFTVGMDVDT RAYFTSATMI IAVPTGIKIF SWLATLHGAQ LSYSPAILWA LGFVFLFTVG GLTGVVLANS SVDIILHDTY YVVAHFHYVL SMGAVFAIMA //