ID NHR52_CAEEL Reviewed; 338 AA. AC O17928; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1998, sequence version 1. DT 13-SEP-2023, entry version 146. DE RecName: Full=Nuclear hormone receptor family member nhr-52; GN Name=nhr-52; ORFNames=K06B4.2; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; OC Caenorhabditis. OX NCBI_TaxID=6239; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=15983867; DOI=10.1007/s00239-004-0175-8; RA Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.; RT "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 RT in nematodes."; RL J. Mol. Evol. 60:577-586(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RT "Genome sequence of the nematode C. elegans: a platform for investigating RT biology."; RL Science 282:2012-2018(1998). CC -!- FUNCTION: Orphan nuclear receptor. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF273797; AAG15146.1; -; Transcribed_RNA. DR EMBL; Z83233; CAB05761.1; -; Genomic_DNA. DR PIR; T23365; T23365. DR AlphaFoldDB; O17928; -. DR SMR; O17928; -. DR STRING; 6239.K06B4.2; -. DR PaxDb; O17928; -. DR EnsemblMetazoa; K06B4.2.1; K06B4.2.1; WBGene00003642. DR KEGG; cel:CELE_K06B4.2; -. DR UCSC; K06B4.2; c. elegans. DR AGR; WB:WBGene00003642; -. DR CTD; 3565623; -. DR WormBase; K06B4.2; CE11784; WBGene00003642; nhr-52. DR eggNOG; KOG3575; Eukaryota. DR GeneTree; ENSGT00970000195839; -. DR HOGENOM; CLU_007368_3_0_1; -. DR InParanoid; O17928; -. DR OMA; KSHEWTF; -. DR OrthoDB; 2882161at2759; -. DR PhylomeDB; O17928; -. DR PRO; PR:O17928; -. DR Proteomes; UP000001940; Chromosome V. DR Bgee; WBGene00003642; Expressed in pharyngeal muscle cell (C elegans). DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro. DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1. DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1. DR InterPro; IPR035500; NHR-like_dom_sf. DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd. DR InterPro; IPR001628; Znf_hrmn_rcpt. DR InterPro; IPR013088; Znf_NHR/GATA. DR PANTHER; PTHR45886:SF2; NUCLEAR HORMONE RECEPTOR FAMILY-RELATED; 1. DR PANTHER; PTHR45886; NUCLEAR HORMONE RECEPTOR FAMILY-RELATED-RELATED; 1. DR Pfam; PF00104; Hormone_recep; 1. DR Pfam; PF00105; zf-C4; 1. DR PRINTS; PR00047; STROIDFINGER. DR SMART; SM00430; HOLI; 1. DR SMART; SM00399; ZnF_C4; 1. DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1. DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1. DR PROSITE; PS51843; NR_LBD; 1. DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1. DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1. PE 2: Evidence at transcript level; KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome; KW Transcription; Transcription regulation; Zinc; Zinc-finger. FT CHAIN 1..338 FT /note="Nuclear hormone receptor family member nhr-52" FT /id="PRO_0000053786" FT DOMAIN 98..337 FT /note="NR LBD" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189" FT DNA_BIND 1..75 FT /note="Nuclear receptor" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407" FT ZN_FING 3..23 FT /note="NR C4-type" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407" FT ZN_FING 39..63 FT /note="NR C4-type" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407" SQ SEQUENCE 338 AA; 39582 MW; 2C6F27E986176E89 CRC64; MKCLVCCSYA SSRNFGALSC SACKMFFTRA TKNYAKFTCK YDKKCFESFT ILPKCQFCRF KKCLEIGMRF SEPKQQLFNL NNSVDQDLII LLGNLAVKDG VHYSNFLNFY SLEDPSMDDI LADRSRMKLM KRTLEIKTKS HEWTFLGSYY KIAQFLDFDF VKTMSLADRK ILFSYNTLRM GSLSRSMRTY LDKRDCLMTP SGDDLFSPAV RGLFDKTPEI INRILCQVVG RLMEIKITYE EYLLLIMIVF CNPSISHELS DSARETLSKY QNMYASFLFR FCQLKNQHKA PTRFNDILSI CNVNNKNVED YCFVHMMFQC MVPEFKFKKL VNDIIIRS //