ID NHR52_CAEEL Reviewed; 338 AA. AC O17928; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1998, sequence version 1. DT 22-JUL-2015, entry version 109. DE RecName: Full=Nuclear hormone receptor family member nhr-52; GN Name=nhr-52; ORFNames=K06B4.2; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis. OX NCBI_TaxID=6239; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=15983867; DOI=10.1007/s00239-004-0175-8; RA Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., RA Sluder A.; RT "Explosive lineage-specific expansion of the orphan nuclear receptor RT HNF4 in nematodes."; RL J. Mol. Evol. 60:577-586(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RT "Genome sequence of the nematode C. elegans: a platform for RT investigating biology."; RL Science 282:2012-2018(1998). CC -!- FUNCTION: Orphan nuclear receptor. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE- CC ProRule:PRU00407}. CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. CC {ECO:0000305}. CC -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain. CC {ECO:0000255|PROSITE-ProRule:PRU00407}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF273797; AAG15146.1; -; Transcribed_RNA. DR EMBL; Z83233; CAB05761.1; -; Genomic_DNA. DR PIR; T23365; T23365. DR RefSeq; NP_506899.1; NM_074498.1. DR UniGene; Cel.2941; -. DR ProteinModelPortal; O17928; -. DR SMR; O17928; 3-298. DR STRING; 6239.K06B4.2; -. DR EnsemblMetazoa; K06B4.2; K06B4.2; WBGene00003642. DR GeneID; 3565623; -. DR KEGG; cel:CELE_K06B4.2; -. DR UCSC; K06B4.2; c. elegans. DR CTD; 3565623; -. DR WormBase; K06B4.2; CE11784; WBGene00003642; nhr-52. DR eggNOG; NOG287260; -. DR GeneTree; ENSGT00530000064378; -. DR HOGENOM; HOG000015902; -. DR InParanoid; O17928; -. DR OMA; CNPSISH; -. DR PhylomeDB; O17928; -. DR NextBio; 957197; -. DR PRO; PR:O17928; -. DR Proteomes; UP000001940; Chromosome V. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. DR GO; GO:0003707; F:steroid hormone receptor activity; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW. DR Gene3D; 1.10.565.10; -; 1. DR Gene3D; 3.30.50.10; -; 1. DR InterPro; IPR008946; Nucl_hormone_rcpt_ligand-bd. DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd_core. DR InterPro; IPR001628; Znf_hrmn_rcpt. DR InterPro; IPR013088; Znf_NHR/GATA. DR Pfam; PF00104; Hormone_recep; 1. DR Pfam; PF00105; zf-C4; 1. DR PRINTS; PR00047; STROIDFINGER. DR SMART; SM00430; HOLI; 1. DR SMART; SM00399; ZnF_C4; 1. DR SUPFAM; SSF48508; SSF48508; 1. DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1. DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1. PE 2: Evidence at transcript level; KW Complete proteome; DNA-binding; Metal-binding; Nucleus; Receptor; KW Reference proteome; Transcription; Transcription regulation; Zinc; KW Zinc-finger. FT CHAIN 1 338 Nuclear hormone receptor family member FT nhr-52. FT /FTId=PRO_0000053786. FT DNA_BIND 1 75 Nuclear receptor. {ECO:0000255|PROSITE- FT ProRule:PRU00407}. FT ZN_FING 3 23 NR C4-type. {ECO:0000255|PROSITE- FT ProRule:PRU00407}. FT ZN_FING 39 63 NR C4-type. {ECO:0000255|PROSITE- FT ProRule:PRU00407}. SQ SEQUENCE 338 AA; 39582 MW; 2C6F27E986176E89 CRC64; MKCLVCCSYA SSRNFGALSC SACKMFFTRA TKNYAKFTCK YDKKCFESFT ILPKCQFCRF KKCLEIGMRF SEPKQQLFNL NNSVDQDLII LLGNLAVKDG VHYSNFLNFY SLEDPSMDDI LADRSRMKLM KRTLEIKTKS HEWTFLGSYY KIAQFLDFDF VKTMSLADRK ILFSYNTLRM GSLSRSMRTY LDKRDCLMTP SGDDLFSPAV RGLFDKTPEI INRILCQVVG RLMEIKITYE EYLLLIMIVF CNPSISHELS DSARETLSKY QNMYASFLFR FCQLKNQHKA PTRFNDILSI CNVNNKNVED YCFVHMMFQC MVPEFKFKKL VNDIIIRS //