ID CED8_CAEEL Reviewed; 458 AA. AC O17386; DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2003, sequence version 2. DT 05-OCT-2016, entry version 94. DE RecName: Full=Cell death abnormality protein 8; GN Name=ced-8; ORFNames=F08F1.5; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis. OX NCBI_TaxID=6239; RN [1] {ECO:0000305} RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION. RX PubMed=10882128; DOI=10.1016/S1097-2765(00)80437-2; RA Stanfield G.M., Horvitz H.R.; RT "The ced-8 gene controls the timing of programmed cell deaths in C. RT elegans."; RL Mol. Cell 5:423-433(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RT "Genome sequence of the nematode C. elegans: a platform for RT investigating biology."; RL Science 282:2012-2018(1998). RN [3] {ECO:0000305} RP FUNCTION, AND DISRUPTION PHENOTYPE. RX PubMed=1936965; RA Ellis R.E., Jacobson D.M., Horvitz H.R.; RT "Genes required for the engulfment of cell corpses during programmed RT cell death in Caenorhabditis elegans."; RL Genetics 129:79-94(1991). RN [4] {ECO:0000305} RP FUNCTION. RX PubMed=9927601; RA Gumienny T.L., Lambie E., Hartwieg E., Horvitz H.R., Hengartner M.O.; RT "Genetic control of programmed cell death in the Caenorhabditis RT elegans hermaphrodite germline."; RL Development 126:1011-1022(1999). RN [5] RP FUNCTION. RX PubMed=23845944; DOI=10.1126/science.1236758; RA Suzuki J., Denning D.P., Imanishi E., Horvitz H.R., Nagata S.; RT "Xk-Related protein 8 and CED-8 promote phosphatidylserine exposure in RT apoptotic cells."; RL Science 341:403-406(2013). CC -!- FUNCTION: Promotes phosphatidylserine exposure on apoptotic cell CC surface, possibly by mediating phospholipid scrambling. CC Phosphatidylserine is a specific marker only present at the CC surface of apoptotic cells and acts as a specific signal for CC engulfment. Acts downstream or in parallel to ced-9. Not required CC for engulfment of germ cell corpses. {ECO:0000269|PubMed:10882128, CC ECO:0000269|PubMed:1936965, ECO:0000269|PubMed:23845944, CC ECO:0000269|PubMed:9927601}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10882128}; CC Multi-pass membrane protein {ECO:0000255, CC ECO:0000269|PubMed:10882128}. CC -!- DISRUPTION PHENOTYPE: Delayed cell death process. CC {ECO:0000269|PubMed:1936965}. CC -!- SIMILARITY: Belongs to the XK family. {ECO:0000255}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FO081089; CCD69028.1; -; Genomic_DNA. DR PIR; T32470; T32470. DR RefSeq; NP_509427.2; NM_077026.6. DR UniGene; Cel.11044; -. DR SMR; O17386; 18-61, 372-398. DR STRING; 6239.F08F1.5; -. DR TCDB; 2.A.112.1.2; 2.a.112. the kx blood-group antigen (kxa) family. DR PaxDb; O17386; -. DR EnsemblMetazoa; F08F1.5; F08F1.5; WBGene00000422. DR GeneID; 184190; -. DR KEGG; cel:CELE_F08F1.5; -. DR UCSC; F08F1.5; c. elegans. DR CTD; 184190; -. DR WormBase; F08F1.5; CE34294; WBGene00000422; ced-8. DR eggNOG; KOG4790; Eukaryota. DR eggNOG; ENOG410YRUD; LUCA. DR GeneTree; ENSGT00530000062854; -. DR HOGENOM; HOG000022315; -. DR InParanoid; O17386; -. DR OMA; ACTHIEK; -. DR OrthoDB; EOG091G0C1B; -. DR PhylomeDB; O17386; -. DR PRO; PR:O17386; -. DR Proteomes; UP000001940; Chromosome X. DR Bgee; WBGene00000422; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB. DR GO; GO:0005215; F:transporter activity; TAS:WormBase. DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:UniProtKB. DR GO; GO:0043652; P:engulfment of apoptotic cell; IMP:UniProtKB. DR GO; GO:0097194; P:execution phase of apoptosis; IMP:UniProtKB. DR GO; GO:0070782; P:phosphatidylserine exposure on apoptotic cell surface; IMP:UniProtKB. DR GO; GO:0012501; P:programmed cell death; IMP:UniProtKB. DR InterPro; IPR018629; XK_rel. DR Pfam; PF09815; XK-related; 1. PE 2: Evidence at transcript level; KW Apoptosis; Cell membrane; Complete proteome; Membrane; KW Reference proteome; Transmembrane; Transmembrane helix. FT CHAIN 1 458 Cell death abnormality protein 8. FT /FTId=PRO_0000379936. FT TRANSMEM 46 66 Helical. {ECO:0000255}. FT TRANSMEM 78 98 Helical. {ECO:0000255}. FT TRANSMEM 124 144 Helical. {ECO:0000255}. FT TRANSMEM 220 240 Helical. {ECO:0000255}. FT TRANSMEM 275 295 Helical. {ECO:0000255}. FT TRANSMEM 318 338 Helical. {ECO:0000255}. FT TRANSMEM 354 374 Helical. {ECO:0000255}. FT TRANSMEM 379 399 Helical. {ECO:0000255}. SQ SEQUENCE 458 AA; 53273 MW; 9E04EEBB0299DB2C CRC64; MFLKKHKSKL LLVPRDEEQE DAGIVAVLTD RIPSVLLVRW FDLFCFGFAM CSYALDFFSD IGIAIFHFWA GRYLSGSLVL AFALLPSVII NIISMVWMLD DEMHWKRRAH PRRTGTFELN QKRFIPLSKM IVLCICQMGP LFWYYKALYY GWMFRKSSNE NTDGEKRKCF SKMVEAERDA TLLRFFEAFL ESAPQLIIQG SIAASYFQNY YQTGTYPYWL YFQAASLLLS IISISWSVVV QNRSLRMIRD DKVNIWPHEA VLQFCWRFLT ILARIITLVA LVLIFGINVV PLISVHLLVT LVHVIFLQAI HIDACTHIEK LLLLINTFIH IFIPFNMVEG NTRWRYLTAY SVEFIEMMLV CWLLPLSLNT FPYIEKVQVG VPISFIAGIA IMMMYYQFFH PNRRQLIVTQ SQEDLSLNVQ KSVETLTPKL ESSLEISGEQ NTSQDLVSEL LLDVEHEN //