ID   CED8_CAEEL              Reviewed;         458 AA.
AC   O17386;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 2.
DT   13-NOV-2013, entry version 79.
DE   RecName: Full=Cell death abnormality protein 8;
GN   Name=ced-8; ORFNames=F08F1.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=10882128; DOI=10.1016/S1097-2765(00)80437-2;
RA   Stanfield G.M., Horvitz H.R.;
RT   "The ced-8 gene controls the timing of programmed cell deaths in C.
RT   elegans.";
RL   Mol. Cell 5:423-433(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=1936965;
RA   Ellis R.E., Jacobson D.M., Horvitz H.R.;
RT   "Genes required for the engulfment of cell corpses during programmed
RT   cell death in Caenorhabditis elegans.";
RL   Genetics 129:79-94(1991).
RN   [4]
RP   FUNCTION.
RX   PubMed=9927601;
RA   Gumienny T.L., Lambie E., Hartwieg E., Horvitz H.R., Hengartner M.O.;
RT   "Genetic control of programmed cell death in the Caenorhabditis
RT   elegans hermaphrodite germline.";
RL   Development 126:1011-1022(1999).
RN   [5]
RP   FUNCTION.
RX   PubMed=23845944; DOI=10.1126/science.1236758;
RA   Suzuki J., Denning D.P., Imanishi E., Horvitz H.R., Nagata S.;
RT   "Xk-Related protein 8 and CED-8 promote phosphatidylserine exposure in
RT   apoptotic cells.";
RL   Science 341:403-406(2013).
CC   -!- FUNCTION: Promotes phosphatidylserine exposure on apoptotic cell
CC       surface, possibly by mediating phospholipid scrambling.
CC       Phosphatidylserine is a specific marker only present at the
CC       surface of apoptotic cells and acts as a specific signal for
CC       engulfment. Acts downstream or in parallel to ced-9. Not required
CC       for engulfment of germ cell corpses.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- DISRUPTION PHENOTYPE: Delayed cell death process.
CC   -!- SIMILARITY: Belongs to the XK family.
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DR   EMBL; FO081089; CCD69028.1; -; Genomic_DNA.
DR   PIR; T32470; T32470.
DR   RefSeq; NP_509427.2; NM_077026.6.
DR   UniGene; Cel.11044; -.
DR   STRING; 6239.F08F1.5; -.
DR   TCDB; 2.A.112.1.2; 2.a.112. the kx blook-group antigen (kxa) family.
DR   EnsemblMetazoa; F08F1.5; F08F1.5; F08F1.5.
DR   GeneID; 184190; -.
DR   KEGG; cel:CELE_F08F1.5; -.
DR   UCSC; F08F1.5; c. elegans.
DR   CTD; 184190; -.
DR   WormBase; F08F1.5; CE34294; WBGene00000422; ced-8.
DR   eggNOG; NOG283702; -.
DR   GeneTree; ENSGT00530000062854; -.
DR   HOGENOM; HOG000022315; -.
DR   InParanoid; O17386; -.
DR   OMA; ACTHIEK; -.
DR   OrthoDB; EOG7RFTHJ; -.
DR   NextBio; 923854; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0005215; F:transporter activity; TAS:WormBase.
DR   GO; GO:0006308; P:DNA catabolic process; IMP:UniProtKB.
DR   GO; GO:0009790; P:embryo development; IMP:UniProtKB.
DR   GO; GO:0043652; P:engulfment of apoptotic cell; IMP:UniProtKB.
DR   GO; GO:0070782; P:phosphatidylserine exposure on apoptotic cell surface; IMP:UniProtKB.
DR   InterPro; IPR018629; Transport_prot_XK.
DR   Pfam; PF09815; XK-related; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cell membrane; Complete proteome; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN         1    458       Cell death abnormality protein 8.
FT                                /FTId=PRO_0000379936.
FT   TRANSMEM     46     66       Helical; (Potential).
FT   TRANSMEM     78     98       Helical; (Potential).
FT   TRANSMEM    124    144       Helical; (Potential).
FT   TRANSMEM    220    240       Helical; (Potential).
FT   TRANSMEM    275    295       Helical; (Potential).
FT   TRANSMEM    318    338       Helical; (Potential).
FT   TRANSMEM    354    374       Helical; (Potential).
FT   TRANSMEM    379    399       Helical; (Potential).
SQ   SEQUENCE   458 AA;  53273 MW;  9E04EEBB0299DB2C CRC64;
     MFLKKHKSKL LLVPRDEEQE DAGIVAVLTD RIPSVLLVRW FDLFCFGFAM CSYALDFFSD
     IGIAIFHFWA GRYLSGSLVL AFALLPSVII NIISMVWMLD DEMHWKRRAH PRRTGTFELN
     QKRFIPLSKM IVLCICQMGP LFWYYKALYY GWMFRKSSNE NTDGEKRKCF SKMVEAERDA
     TLLRFFEAFL ESAPQLIIQG SIAASYFQNY YQTGTYPYWL YFQAASLLLS IISISWSVVV
     QNRSLRMIRD DKVNIWPHEA VLQFCWRFLT ILARIITLVA LVLIFGINVV PLISVHLLVT
     LVHVIFLQAI HIDACTHIEK LLLLINTFIH IFIPFNMVEG NTRWRYLTAY SVEFIEMMLV
     CWLLPLSLNT FPYIEKVQVG VPISFIAGIA IMMMYYQFFH PNRRQLIVTQ SQEDLSLNVQ
     KSVETLTPKL ESSLEISGEQ NTSQDLVSEL LLDVEHEN
//