ID ZBT22_HUMAN Reviewed; 634 AA. AC O15209; B0V007; Q5HYV4; Q5STL0; Q5STR7; Q8WV82; DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1998, sequence version 1. DT 29-MAY-2024, entry version 199. DE RecName: Full=Zinc finger and BTB domain-containing protein 22; DE AltName: Full=Protein BING1; DE AltName: Full=Zinc finger and BTB domain-containing protein 22A; DE AltName: Full=Zinc finger protein 297; GN Name=ZBTB22; Synonyms=BING1, ZBTB22A, ZNF297; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=9545376; DOI=10.1006/jmbi.1998.1637; RA Herberg J.A., Beck S., Trowsdale J.; RT "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense RT cluster at the centromeric end of the MHC."; RL J. Mol. Biol. 277:839-857(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-310. RC TISSUE=Brain; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ALA-310. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., RA Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-310. RC TISSUE=Lymph; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). CC -!- FUNCTION: May be involved in transcriptional regulation. CC -!- INTERACTION: CC O15209; Q8IYE1: CCDC13; NbExp=3; IntAct=EBI-723574, EBI-10961312; CC O15209; P51116: FXR2; NbExp=3; IntAct=EBI-723574, EBI-740459; CC O15209; Q9H0R8: GABARAPL1; NbExp=4; IntAct=EBI-723574, EBI-746969; CC O15209; O95995: GAS8; NbExp=3; IntAct=EBI-723574, EBI-1052570; CC O15209; Q96EZ8: MCRS1; NbExp=6; IntAct=EBI-723574, EBI-348259; CC O15209; Q9Y316: MEMO1; NbExp=3; IntAct=EBI-723574, EBI-1104564; CC O15209; Q6P2C6: MLLT6; NbExp=3; IntAct=EBI-723574, EBI-5773143; CC O15209; Q13526: PIN1; NbExp=3; IntAct=EBI-723574, EBI-714158; CC O15209; Q14498-3: RBM39; NbExp=3; IntAct=EBI-723574, EBI-6654703; CC O15209; Q15560: TCEA2; NbExp=3; IntAct=EBI-723574, EBI-710310; CC O15209; Q9P0L0: VAPA; NbExp=3; IntAct=EBI-723574, EBI-1059156; CC O15209; O95292: VAPB; NbExp=3; IntAct=EBI-723574, EBI-1188298; CC O15209; A8KA83; NbExp=3; IntAct=EBI-723574, EBI-10174961; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein CC family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z97183; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; Z97184; CAB09990.1; -; Genomic_DNA. DR EMBL; AK315747; BAG38101.1; -; mRNA. DR EMBL; AL662820; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL662827; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX248088; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759786; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759817; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471081; EAX03721.1; -; Genomic_DNA. DR EMBL; BC018541; AAH18541.1; -; mRNA. DR CCDS; CCDS4775.1; -. DR RefSeq; NP_001138810.1; NM_001145338.1. DR RefSeq; NP_005444.4; NM_005453.4. DR AlphaFoldDB; O15209; -. DR SMR; O15209; -. DR BioGRID; 114695; 19. DR DIP; DIP-62047N; -. DR IntAct; O15209; 18. DR STRING; 9606.ENSP00000407545; -. DR iPTMnet; O15209; -. DR PhosphoSitePlus; O15209; -. DR BioMuta; ZBTB22; -. DR EPD; O15209; -. DR jPOST; O15209; -. DR MassIVE; O15209; -. DR MaxQB; O15209; -. DR PaxDb; 9606-ENSP00000407545; -. DR PeptideAtlas; O15209; -. DR ProteomicsDB; 48510; -. DR Antibodypedia; 29118; 131 antibodies from 22 providers. DR DNASU; 9278; -. DR Ensembl; ENST00000383196.4; ENSP00000372683.4; ENSG00000206280.7. DR Ensembl; ENST00000416097.2; ENSP00000393514.2; ENSG00000229253.5. DR Ensembl; ENST00000418540.2; ENSP00000388191.2; ENSG00000227780.5. DR Ensembl; ENST00000418724.1; ENSP00000404403.1; ENSG00000236104.3. DR Ensembl; ENST00000431845.3; ENSP00000407545.2; ENSG00000236104.3. DR Ensembl; ENST00000445320.2; ENSP00000396292.2; ENSG00000237056.5. DR GeneID; 9278; -. DR KEGG; hsa:9278; -. DR MANE-Select; ENST00000431845.3; ENSP00000407545.2; NM_005453.5; NP_005444.4. DR UCSC; uc003oeb.4; human. DR AGR; HGNC:13085; -. DR CTD; 9278; -. DR DisGeNET; 9278; -. DR GeneCards; ZBTB22; -. DR HGNC; HGNC:13085; ZBTB22. DR HPA; ENSG00000236104; Low tissue specificity. DR MIM; 611439; gene. DR neXtProt; NX_O15209; -. DR OpenTargets; ENSG00000236104; -. DR PharmGKB; PA37661; -. DR VEuPathDB; HostDB:ENSG00000236104; -. DR eggNOG; KOG1721; Eukaryota. DR GeneTree; ENSGT00940000160991; -. DR HOGENOM; CLU_029118_2_0_1; -. DR InParanoid; O15209; -. DR OMA; PYDCLSC; -. DR OrthoDB; 5342883at2759; -. DR PhylomeDB; O15209; -. DR PathwayCommons; O15209; -. DR SignaLink; O15209; -. DR BioGRID-ORCS; 9278; 8 hits in 1186 CRISPR screens. DR ChiTaRS; ZBTB22; human. DR GenomeRNAi; 9278; -. DR Pharos; O15209; Tbio. DR PRO; PR:O15209; -. DR Proteomes; UP000005640; Chromosome 6. DR RNAct; O15209; Protein. DR Bgee; ENSG00000236104; Expressed in apex of heart and 96 other cell types or tissues. DR ExpressionAtlas; O15209; baseline and differential. DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB. DR GO; GO:0005634; C:nucleus; TAS:ProtInc. DR GO; GO:0003677; F:DNA binding; TAS:ProtInc. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR CDD; cd18210; BTB_POZ_ZBTB22_BING1; 1. DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1. DR InterPro; IPR000210; BTB/POZ_dom. DR InterPro; IPR011333; SKP1/BTB/POZ_sf. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR46105; AGAP004733-PA; 1. DR PANTHER; PTHR46105:SF14; ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 22; 1. DR Pfam; PF00651; BTB; 1. DR SMART; SM00225; BTB; 1. DR SMART; SM00355; ZnF_C2H2; 3. DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1. DR SUPFAM; SSF54695; POZ domain; 1. DR PROSITE; PS50097; BTB; 1. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2. PE 1: Evidence at protein level; KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. FT CHAIN 1..634 FT /note="Zinc finger and BTB domain-containing protein 22" FT /id="PRO_0000047517" FT DOMAIN 57..121 FT /note="BTB" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037" FT ZN_FING 486..507 FT /note="C2H2-type 1; atypical" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 513..535 FT /note="C2H2-type 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 541..562 FT /note="C2H2-type 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT REGION 167..247 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 308..461 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 568..634 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 181..227 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 316..340 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 425..445 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 202 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT VARIANT 250 FT /note="G -> A (in dbSNP:rs35663442)" FT /id="VAR_057457" FT VARIANT 310 FT /note="T -> A (in dbSNP:rs3130100)" FT /evidence="ECO:0000269|PubMed:14574404, FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334" FT /id="VAR_022702" SQ SEQUENCE 634 AA; 65602 MW; 9CC1867213D6DEF7 CRC64; MEPSPLSPSG AALPLPLSLA PPPLPLPAAA VVHVSFPEVT SALLESLNQQ RLQGQLCDVS IRVQGREFRA HRAVLAASSP YFHDQVLLKG MTSISLPSVM DPGAFETVLA SAYTGRLSMA AADIVNFLTV GSVLQMWHIV DKCTELLREG RASATTTITT AAATSVTVPG AGVPSGSGGT VAPATMGSAR SHASSRASEN QSPSSSNYFS PRESTDFSSS SQEAFAASAV GSGERRGGGP VFPAPVVGSG GATSGKLLLE ADELCDDGGD GRGAVVPGAG LRRPTYTPPS IMPQKHWVYV KRGGNCPAPT PLVPQDPDLE EEEEEEDLVL TCEDDEDEEL GGSSRVPVGG GPEATLSISD VRTLSEPPDK GEEQVNFCES SNDFGPYEGG GPVAGLDDSG GPTPSSYAPS HPPRPLLPLD MQGNQILVFP SSSSSSSSQA PGQPPGNQAE HGAVTVGGTS VGSLGVPGSV GGVPGGTGSG DGNKIFLCHC GKAFSHKSMR DRHVNMHLNL RPFDCPVCNK KFKMKHHLTE HMKTHTGLKP YECGVCAKKF MWRDSFMRHR GHCERRHRLG GVGAVPGPGT PTGPSLPSKR ESPGVGGGSG DEASAATPPS SRRVWSPPRV HKVEMGFGGG GGAN //