ID ZBT22_HUMAN Reviewed; 634 AA. AC O15209; B0V007; Q5HYV4; Q5STL0; Q5STR7; Q8WV82; DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1998, sequence version 1. DT 12-SEP-2018, entry version 168. DE RecName: Full=Zinc finger and BTB domain-containing protein 22; DE AltName: Full=Protein BING1; DE AltName: Full=Zinc finger and BTB domain-containing protein 22A; DE AltName: Full=Zinc finger protein 297; GN Name=ZBTB22; Synonyms=BING1, ZBTB22A, ZNF297; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=9545376; DOI=10.1006/jmbi.1998.1637; RA Herberg J.A., Beck S., Trowsdale J.; RT "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a RT dense cluster at the centromeric end of the MHC."; RL J. Mol. Biol. 277:839-857(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-310. RC TISSUE=Brain; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ALA-310. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-310. RC TISSUE=Lymph; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). CC -!- FUNCTION: May be involved in transcriptional regulation. CC -!- INTERACTION: CC A8KA83:-; NbExp=3; IntAct=EBI-723574, EBI-10174961; CC P51116:FXR2; NbExp=3; IntAct=EBI-723574, EBI-740459; CC Q96EZ8:MCRS1; NbExp=5; IntAct=EBI-723574, EBI-348259; CC Q6P2C6:MLLT6; NbExp=3; IntAct=EBI-723574, EBI-5773143; CC Q13526:PIN1; NbExp=3; IntAct=EBI-723574, EBI-714158; CC Q14498-3:RBM39; NbExp=3; IntAct=EBI-723574, EBI-6654703; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein CC family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z97183; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; Z97184; CAB09990.1; -; Genomic_DNA. DR EMBL; AK315747; BAG38101.1; -; mRNA. DR EMBL; AL662820; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL662827; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX248088; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759786; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759817; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471081; EAX03721.1; -; Genomic_DNA. DR EMBL; BC018541; AAH18541.1; -; mRNA. DR CCDS; CCDS4775.1; -. DR RefSeq; NP_001138810.1; NM_001145338.1. DR RefSeq; NP_005444.4; NM_005453.4. DR UniGene; Hs.206770; -. DR ProteinModelPortal; O15209; -. DR SMR; O15209; -. DR BioGrid; 114695; 13. DR DIP; DIP-62047N; -. DR IntAct; O15209; 17. DR STRING; 9606.ENSP00000404403; -. DR iPTMnet; O15209; -. DR PhosphoSitePlus; O15209; -. DR BioMuta; ZBTB22; -. DR EPD; O15209; -. DR MaxQB; O15209; -. DR PaxDb; O15209; -. DR PeptideAtlas; O15209; -. DR PRIDE; O15209; -. DR ProteomicsDB; 48510; -. DR DNASU; 9278; -. DR Ensembl; ENST00000383196; ENSP00000372683; ENSG00000206280. DR Ensembl; ENST00000416097; ENSP00000393514; ENSG00000229253. DR Ensembl; ENST00000418540; ENSP00000388191; ENSG00000227780. DR Ensembl; ENST00000418724; ENSP00000404403; ENSG00000236104. DR Ensembl; ENST00000431845; ENSP00000407545; ENSG00000236104. DR Ensembl; ENST00000445320; ENSP00000396292; ENSG00000237056. DR GeneID; 9278; -. DR KEGG; hsa:9278; -. DR UCSC; uc003oeb.4; human. DR CTD; 9278; -. DR DisGeNET; 9278; -. DR EuPathDB; HostDB:ENSG00000236104.2; -. DR GeneCards; ZBTB22; -. DR HGNC; HGNC:13085; ZBTB22. DR HPA; HPA043848; -. DR MIM; 611439; gene. DR neXtProt; NX_O15209; -. DR OpenTargets; ENSG00000236104; -. DR PharmGKB; PA37661; -. DR eggNOG; KOG1721; Eukaryota. DR eggNOG; COG5048; LUCA. DR GeneTree; ENSGT00760000119063; -. DR HOGENOM; HOG000231975; -. DR HOVERGEN; HBG056510; -. DR InParanoid; O15209; -. DR KO; K10502; -. DR OMA; EPPDKGE; -. DR OrthoDB; EOG09370O8X; -. DR PhylomeDB; O15209; -. DR ChiTaRS; ZBTB22; human. DR GenomeRNAi; 9278; -. DR PRO; PR:O15209; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000236104; Expressed in 90 organ(s), highest expression level in anterior cingulate cortex. DR CleanEx; HS_ZBTB22; -. DR ExpressionAtlas; O15209; baseline and differential. DR Genevisible; O15209; HS. DR GO; GO:0005634; C:nucleus; TAS:ProtInc. DR GO; GO:0003677; F:DNA binding; TAS:ProtInc. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW. DR InterPro; IPR000210; BTB/POZ_dom. DR InterPro; IPR011333; SKP1/BTB/POZ_sf. DR InterPro; IPR029833; ZBT22. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR24414:SF4; PTHR24414:SF4; 1. DR Pfam; PF00651; BTB; 1. DR SMART; SM00225; BTB; 1. DR SMART; SM00355; ZnF_C2H2; 3. DR SUPFAM; SSF54695; SSF54695; 1. DR SUPFAM; SSF57667; SSF57667; 1. DR PROSITE; PS50097; BTB; 1. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2. PE 1: Evidence at protein level; KW Complete proteome; DNA-binding; Metal-binding; Nucleus; KW Phosphoprotein; Polymorphism; Reference proteome; Repeat; KW Transcription; Transcription regulation; Zinc; Zinc-finger. FT CHAIN 1 634 Zinc finger and BTB domain-containing FT protein 22. FT /FTId=PRO_0000047517. FT DOMAIN 57 121 BTB. {ECO:0000255|PROSITE- FT ProRule:PRU00037}. FT ZN_FING 486 507 C2H2-type 1; atypical. FT {ECO:0000255|PROSITE-ProRule:PRU00042}. FT ZN_FING 513 535 C2H2-type 2. {ECO:0000255|PROSITE- FT ProRule:PRU00042}. FT ZN_FING 541 562 C2H2-type 3. {ECO:0000255|PROSITE- FT ProRule:PRU00042}. FT MOD_RES 202 202 Phosphoserine. FT {ECO:0000244|PubMed:23186163}. FT VARIANT 250 250 G -> A (in dbSNP:rs35663442). FT /FTId=VAR_057457. FT VARIANT 310 310 T -> A (in dbSNP:rs3130100). FT {ECO:0000269|PubMed:14574404, FT ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334}. FT /FTId=VAR_022702. SQ SEQUENCE 634 AA; 65602 MW; 9CC1867213D6DEF7 CRC64; MEPSPLSPSG AALPLPLSLA PPPLPLPAAA VVHVSFPEVT SALLESLNQQ RLQGQLCDVS IRVQGREFRA HRAVLAASSP YFHDQVLLKG MTSISLPSVM DPGAFETVLA SAYTGRLSMA AADIVNFLTV GSVLQMWHIV DKCTELLREG RASATTTITT AAATSVTVPG AGVPSGSGGT VAPATMGSAR SHASSRASEN QSPSSSNYFS PRESTDFSSS SQEAFAASAV GSGERRGGGP VFPAPVVGSG GATSGKLLLE ADELCDDGGD GRGAVVPGAG LRRPTYTPPS IMPQKHWVYV KRGGNCPAPT PLVPQDPDLE EEEEEEDLVL TCEDDEDEEL GGSSRVPVGG GPEATLSISD VRTLSEPPDK GEEQVNFCES SNDFGPYEGG GPVAGLDDSG GPTPSSYAPS HPPRPLLPLD MQGNQILVFP SSSSSSSSQA PGQPPGNQAE HGAVTVGGTS VGSLGVPGSV GGVPGGTGSG DGNKIFLCHC GKAFSHKSMR DRHVNMHLNL RPFDCPVCNK KFKMKHHLTE HMKTHTGLKP YECGVCAKKF MWRDSFMRHR GHCERRHRLG GVGAVPGPGT PTGPSLPSKR ESPGVGGGSG DEASAATPPS SRRVWSPPRV HKVEMGFGGG GGAN //