ID NPFF_HUMAN Reviewed; 113 AA. AC O15130; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1998, sequence version 1. DT 24-JUL-2013, entry version 97. DE RecName: Full=FMRFamide-related peptides; DE Contains: DE RecName: Full=Neuropeptide SF; DE Short=NPSF; DE Contains: DE RecName: Full=Neuropeptide FF; DE Short=NPFF; DE Contains: DE RecName: Full=Neuropeptide AF; DE Short=NPAF; DE Flags: Precursor; GN Name=NPFF; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Testis; RX PubMed=9224703; DOI=10.1016/S0014-5793(97)00557-7; RA Perry S.J., Yi-Kung Huang E., Cronk D., Bagust J., Sharma R., RA Walker R.J., Wilson S., Burke J.F.; RT "A human gene encoding morphine modulating peptides related to NPFF RT and FMRFamide."; RL FEBS Lett. 409:426-430(1997). RN [2] RP FUNCTION. RX PubMed=11587714; DOI=10.1016/S0028-3908(01)00107-1; RA Catarsi S., Babinski K., Seguela P.; RT "Selective modulation of heteromeric ASIC proton-gated channels by RT neuropeptide FF."; RL Neuropharmacology 41:592-600(2001). CC -!- FUNCTION: Morphine modulating peptides. Have wide-ranging CC physiologic effects, including the modulation of morphine-induced CC analgesia, elevation of arterial blood pressure, and increased CC somatostatin secretion from the pancreas. Neuropeptide FF CC potentiates and sensitizes ASIC1 and ASIC3 channels. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF005271; AAB64288.1; -; mRNA. DR IPI; IPI00005140; -. DR RefSeq; NP_003708.1; NM_003717.2. DR UniGene; Hs.733076; -. DR ProteinModelPortal; O15130; -. DR STRING; 9606.ENSP00000267017; -. DR PaxDb; O15130; -. DR PRIDE; O15130; -. DR Ensembl; ENST00000267017; ENSP00000267017; ENSG00000139574. DR GeneID; 8620; -. DR KEGG; hsa:8620; -. DR UCSC; uc001sdw.1; human. DR CTD; 8620; -. DR GeneCards; GC12M053896; -. DR HGNC; HGNC:7901; NPFF. DR MIM; 604643; gene. DR neXtProt; NX_O15130; -. DR PharmGKB; PA31704; -. DR eggNOG; NOG44970; -. DR HOGENOM; HOG000113843; -. DR HOVERGEN; HBG006519; -. DR InParanoid; O15130; -. DR KO; K05247; -. DR OMA; MDSRQAA; -. DR OrthoDB; EOG49PB16; -. DR PhylomeDB; O15130; -. DR Reactome; REACT_111102; Signal Transduction. DR GeneWiki; NPFF; -. DR GenomeRNAi; 8620; -. DR NextBio; 32299; -. DR Bgee; O15130; -. DR CleanEx; HS_NPFF; -. DR Genevestigator; O15130; -. DR GO; GO:0043679; C:axon terminus; IEA:Compara. DR GO; GO:0030425; C:dendrite; IEA:Compara. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0005615; C:extracellular space; IEA:Compara. DR GO; GO:0043204; C:perikaryon; IEA:Compara. DR GO; GO:0031982; C:vesicle; IEA:Compara. DR GO; GO:0005102; F:receptor binding; TAS:ProtInc. DR GO; GO:0002438; P:acute inflammatory response to antigenic stimulus; IEA:Compara. DR GO; GO:0007204; P:elevation of cytosolic calcium ion concentration; IEA:Compara. DR GO; GO:0060135; P:maternal process involved in female pregnancy; IEA:Compara. DR GO; GO:0032099; P:negative regulation of appetite; IEA:Compara. DR GO; GO:0010459; P:negative regulation of heart rate; IEA:Compara. DR GO; GO:0046676; P:negative regulation of insulin secretion; IEA:Compara. DR GO; GO:0007218; P:neuropeptide signaling pathway; TAS:ProtInc. DR GO; GO:0045777; P:positive regulation of blood pressure; IEA:Compara. DR GO; GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IEA:Compara. DR GO; GO:0051930; P:regulation of sensory perception of pain; IEA:Compara. DR GO; GO:0042493; P:response to drug; IEA:Compara. DR GO; GO:0043278; P:response to morphine; IEA:Compara. DR GO; GO:0070253; P:somatostatin secretion; IEA:Compara. DR GO; GO:0021510; P:spinal cord development; IEA:Compara. DR GO; GO:0007268; P:synaptic transmission; TAS:ProtInc. DR GO; GO:0030103; P:vasopressin secretion; IEA:Compara. DR InterPro; IPR008065; FMRFamid-related_peptide. DR PANTHER; PTHR15044; PTHR15044; 1. DR PIRSF; PIRSF038092; FMRFamid-rel_pep_precur; 1. DR PRINTS; PR01682; FMRFAMIDEPEP. PE 2: Evidence at transcript level; KW Amidation; Cleavage on pair of basic residues; Complete proteome; KW Neuropeptide; Polymorphism; Reference proteome; Secreted; Signal. FT SIGNAL 1 20 Potential. FT PROPEP 21 65 FT /FTId=PRO_0000009898. FT PEPTIDE 66 76 Neuropeptide SF. FT /FTId=PRO_0000009899. FT PEPTIDE 69 76 Neuropeptide FF. FT /FTId=PRO_0000009900. FT PROPEP 79 92 FT /FTId=PRO_0000009901. FT PEPTIDE 93 110 Neuropeptide AF. FT /FTId=PRO_0000009902. FT MOD_RES 76 76 Phenylalanine amide (By similarity). FT MOD_RES 110 110 Phenylalanine amide (By similarity). FT VARIANT 88 88 W -> R (in dbSNP:rs35822762). FT /FTId=VAR_049183. SQ SEQUENCE 113 AA; 12440 MW; 1E9D4ED2A69238E3 CRC64; MDSRQAAALL VLLLLIDGGC AEGPGGQQED QLSAEEDSEP LPPQDAQTSG SLLHYLLQAM ERPGRSQAFL FQPQRFGRNT QGSWRNEWLS PRAGEGLNSQ FWSLAAPQRF GKK //