ID   TAAR5_HUMAN             Reviewed;         337 AA.
AC   O14804; D8KZS1; Q2M1V1; Q4VBL1; Q5VUQ3; Q6NTA8;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 2.
DT   12-AUG-2020, entry version 150.
DE   RecName: Full=Trace amine-associated receptor 5;
DE            Short=TaR-5;
DE            Short=Trace amine receptor 5;
DE            Short=hTaar5;
DE   AltName: Full=Putative neurotransmitter receptor;
GN   Name=TAAR5; Synonyms=PNR;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=9464258; DOI=10.1006/bbrc.1997.7591;
RA   Zeng Z., Fan P., Rand E., Kyaw H., Su K., Madike V., Carter K.C., Li Y.;
RT   "Cloning of a putative human neurotransmitter receptor expressed in
RT   skeletal muscle and brain.";
RL   Biochem. Biophys. Res. Commun. 242:575-578(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010;
RA   Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K.,
RA   Hoener M.C.;
RT   "Trace amine-associated receptors form structurally and functionally
RT   distinct subfamilies of novel G protein-coupled receptors.";
RL   Genomics 85:372-385(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=20559446; DOI=10.1371/journal.pone.0011133;
RA   Staubert C., Boselt I., Bohnekamp J., Rompler H., Enard W., Schoneberg T.;
RT   "Structural and functional evolution of the trace amine-associated
RT   receptors TAAR3, TAAR4 and TAAR5 in primates.";
RL   PLoS ONE 5:E11133-E11133(2010).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=23393561; DOI=10.1371/journal.pone.0054950;
RA   Wallrabenstein I., Kuklan J., Weber L., Zborala S., Werner M.,
RA   Altmuller J., Becker C., Schmidt A., Hatt H., Hummel T., Gisselmann G.;
RT   "Human trace amine-associated receptor TAAR5 can be activated by
RT   trimethylamine.";
RL   PLoS ONE 8:E54950-E54950(2013).
CC   -!- FUNCTION: Olfactory receptor specific for trimethylamine, a trace
CC       amine. Also activated at lower level by dimethylethylamine.
CC       Trimethylamine is a bacterial metabolite found in some animal odors,
CC       and to humans it is a repulsive odor associated with bad breath and
CC       spoiled food. This receptor is probably mediated by the G(s)-class of
CC       G-proteins which activate adenylate cyclase.
CC       {ECO:0000269|PubMed:23393561}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23393561};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:23393561}.
CC   -!- TISSUE SPECIFICITY: Expressed almost exclusively in skeletal muscle and
CC       selected areas of the brain, such amygdala, hippocampus, caudate
CC       nucleus, thalamus and hypothalamus. Weak expression is also find in
CC       substantia nigra. {ECO:0000269|PubMed:9464258}.
CC   -!- MISCELLANEOUS: Polymorphic variants of this gene are not associated
CC       with specific anosmia for trimethylamine.
CC       {ECO:0000305|PubMed:23393561}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF021818; AAC39581.1; -; mRNA.
DR   EMBL; AY702306; AAV70123.1; -; Genomic_DNA.
DR   EMBL; FJ372547; ACP18682.1; -; Genomic_DNA.
DR   EMBL; AL513524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471051; EAW48025.1; -; Genomic_DNA.
DR   EMBL; BC069171; AAH69171.1; -; mRNA.
DR   EMBL; BC095541; AAH95541.1; -; mRNA.
DR   EMBL; BC112209; AAI12210.1; -; mRNA.
DR   EMBL; BC112211; AAI12212.1; -; mRNA.
DR   CCDS; CCDS5156.1; -.
DR   PIR; JC5832; JC5832.
DR   RefSeq; NP_003958.2; NM_003967.2.
DR   SMR; O14804; -.
DR   STRING; 9606.ENSP00000258034; -.
DR   ChEMBL; CHEMBL3714046; -.
DR   GlyGen; O14804; 1 site.
DR   PhosphoSitePlus; O14804; -.
DR   BioMuta; TAAR5; -.
DR   EPD; O14804; -.
DR   PaxDb; O14804; -.
DR   PeptideAtlas; O14804; -.
DR   PRIDE; O14804; -.
DR   ProteomicsDB; 48249; -.
DR   Antibodypedia; 19709; 215 antibodies.
DR   DNASU; 9038; -.
DR   Ensembl; ENST00000258034; ENSP00000258034; ENSG00000135569.
DR   GeneID; 9038; -.
DR   KEGG; hsa:9038; -.
DR   UCSC; uc003qdk.3; human.
DR   CTD; 9038; -.
DR   DisGeNET; 9038; -.
DR   EuPathDB; HostDB:ENSG00000135569.4; -.
DR   GeneCards; TAAR5; -.
DR   HGNC; HGNC:30236; TAAR5.
DR   HPA; ENSG00000135569; Not detected.
DR   MIM; 607405; gene.
DR   neXtProt; NX_O14804; -.
DR   OpenTargets; ENSG00000135569; -.
DR   PharmGKB; PA142670843; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00940000161258; -.
DR   HOGENOM; CLU_009579_11_0_1; -.
DR   InParanoid; O14804; -.
DR   KO; K05051; -.
DR   OMA; YQWFRKA; -.
DR   OrthoDB; 913195at2759; -.
DR   PhylomeDB; O14804; -.
DR   TreeFam; TF343107; -.
DR   PathwayCommons; O14804; -.
DR   Reactome; R-HSA-375280; Amine ligand-binding receptors.
DR   Reactome; R-HSA-418555; G alpha (s) signalling events.
DR   Reactome; R-HSA-9660821; ADORA2B mediated anti-inflammatory cytokines production.
DR   BioGRID-ORCS; 9038; 5 hits in 863 CRISPR screens.
DR   GeneWiki; TAAR5; -.
DR   GenomeRNAi; 9038; -.
DR   Pharos; O14804; Tchem.
DR   PRO; PR:O14804; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; O14804; protein.
DR   Bgee; ENSG00000135569; Expressed in forebrain and 7 other tissues.
DR   Genevisible; O14804; HS.
DR   GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; TAS:GDB.
DR   GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR   GO; GO:1990081; F:trimethylamine receptor activity; IDA:UniProtKB.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:GDB.
DR   GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR009132; TAAR_fam.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01830; TRACEAMINER.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Polymorphism; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..337
FT                   /note="Trace amine-associated receptor 5"
FT                   /id="PRO_0000070154"
FT   TOPO_DOM        1..34
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        56..70
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        92..109
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        131..154
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        176..204
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        226..253
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        275..284
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..307
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        308..337
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        21
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        99..192
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         272
FT                   /note="T -> M (in dbSNP:rs34746740)"
FT                   /id="VAR_055923"
FT   VARIANT         330
FT                   /note="R -> C (in dbSNP:rs35839363)"
FT                   /id="VAR_055924"
FT   CONFLICT        16
FT                   /note="F -> L (in Ref. 6; AAH95541)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        40
FT                   /note="A -> T (in Ref. 1; AAC39581)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        80
FT                   /note="D -> N (in Ref. 6; AAH69171)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        257
FT                   /note="A -> V (in Ref. 1; AAC39581)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        332
FT                   /note="V -> A (in Ref. 6; AAH95541)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   337 AA;  38242 MW;  251DB41A13A5535A CRC64;
     MRAVFIQGAE EHPAAFCYQV NGSCPRTVHT LGIQLVIYLA CAAGMLIIVL GNVFVAFAVS
     YFKALHTPTN FLLLSLALAD MFLGLLVLPL STIRSVESCW FFGDFLCRLH TYLDTLFCLT
     SIFHLCFISI DRHCAICDPL LYPSKFTVRV ALRYILAGWG VPAAYTSLFL YTDVVETRLS
     QWLEEMPCVG SCQLLLNKFW GWLNFPLFFV PCLIMISLYV KIFVVATRQA QQITTLSKSL
     AGAAKHERKA AKTLGIAVGI YLLCWLPFTI DTMVDSLLHF ITPPLVFDIF IWFAYFNSAC
     NPIIYVFSYQ WFRKALKLTL SQKVFSPQTR TVDLYQE
//