ID TYB4Y_HUMAN STANDARD; PRT; 43 AA. AC O14604; DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1999, sequence version 2. DT 18-APR-2006, entry version 44. DE Thymosin beta-4, Y-chromosomal. GN Name=TMSB4Y; Synonyms=TB4Y; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=98022381; PubMed=9381176; DOI=10.1126/science.278.5338.675; RA Lahn B.T., Page D.C.; RT "Functional coherence of the human Y chromosome."; RL Science 278:675-680(1997). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=22699787; PubMed=12815422; DOI=10.1038/nature01722; RA Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., RA Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., RA Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., RA Fulton L., Fulton R., Graves T.A., Hou S.-F., Latrielle P., RA Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., RA Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., RA Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., RA Wilson R.K., Rozen S., Page D.C.; RT "The male-specific region of the human Y chromosome is a mosaic of RT discrete sequence classes."; RL Nature 423:825-837(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Hypothalamus; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Plays an important role in the organization of the CC cytoskeleton. Binds to and sequesters actin monomers (G actin) and CC therefore inhibits actin polymerization (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- TISSUE SPECIFICITY: Ubiquitous. CC -!- SIMILARITY: Belongs to the thymosin beta family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF000989; AAC51836.1; -; mRNA. DR EMBL; AC006371; AAD54509.1; -; Genomic_DNA. DR EMBL; BC022482; AAH22482.1; -; mRNA. DR UniGene; Hs.159201; -. DR HSSP; P21752; 1HJ0. DR Ensembl; ENSG00000154620; Homo sapiens. DR H-InvDB; HIX0017187; -. DR HGNC; HGNC:11882; TMSB4Y. DR MIM; 400017; gene. DR GO; GO:0008064; P:regulation of actin polymerization and/or d...; TAS. DR GO; GO:0042989; P:sequestering of actin monomers; TAS. DR InterPro; IPR001152; Thymosin_b4. DR PANTHER; PTHR12021; Thymosin_b4; 1. DR Pfam; PF01290; Thymosin; 1. DR ProDom; PD005116; Thymosin_b4; 1. DR SMART; SM00152; THY; 1. DR PROSITE; PS00500; THYMOSIN_B4; 1. KW Acetylation; Actin-binding; Cytoskeleton. FT INIT_MET 0 0 By similarity. FT PEPTIDE 1 43 Thymosin beta-4, Y-chromosomal. FT /FTId=PRO_0000045921. FT MOD_RES 1 1 N-acetylserine (By similarity). SQ SEQUENCE 43 AA; 4881 MW; 7B336102870632E2 CRC64; SDKPGMAEIE KFDKSKLKKT ETQEKNPLSS KETIEQERQA GES //