ID TYBY_HUMAN STANDARD; PRT; 43 AA. AC O14604; DT 15-JUL-1999 (Rel. 38, Created) DT 15-JUL-1999 (Rel. 38, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Thymosin beta-4, Y-chromosomal. GN Name=TMSB4Y; Synonyms=TB4Y; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=98022381; PubMed=9381176; RA Lahn B.T., Page D.C.; RT "Functional coherence of the human Y chromosome."; RL Science 278:675-680(1997). RN [2] RP SEQUENCE FROM N.A. RA Du H., Wohldman P., Le T.; RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases. RN [3] RP SEQUENCE FROM N.A. RC TISSUE=Hypothalamus; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Plays an important role in the organization of the CC cytoskeleton. Binds to and sequesters actin monomers (G actin) and CC therefore inhibits actin polymerization (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasmic (By similarity). CC -!- TISSUE SPECIFICITY: Ubiquitous. CC -!- SIMILARITY: Belongs to the thymosin beta family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF000989; AAC51836.1; -. DR EMBL; AC006371; AAD54509.1; -. DR EMBL; BC022482; AAH22482.1; -. DR HSSP; P21752; 1HJ0. DR Genew; HGNC:11882; TMSB4Y. DR MIM; 400017; -. DR GO; GO:0008064; P:regulation of actin polymerization and/or d...; TAS. DR GO; GO:0042989; P:sequestering of actin monomers; TAS. DR InterPro; IPR001152; Thymosin_b4. DR Pfam; PF01290; Thymosin; 1. DR ProDom; PD005116; Thymosin_b4; 1. DR SMART; SM00152; THY; 1. DR PROSITE; PS00500; THYMOSIN_B4; 1. KW Acetylation; Actin-binding; Cytoskeleton. FT INIT_MET 0 0 By similarity. FT MOD_RES 1 1 N-acetylserine (By similarity). SQ SEQUENCE 43 AA; 4881 MW; 7B336102870632E2 CRC64; SDKPGMAEIE KFDKSKLKKT ETQEKNPLSS KETIEQERQA GES //