ID TYB4Y_HUMAN Reviewed; 44 AA. AC O14604; Q0VDA2; DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 3. DT 27-NOV-2024, entry version 187. DE RecName: Full=Thymosin beta-4, Y-chromosomal; GN Name=TMSB4Y; Synonyms=TB4Y; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=9381176; DOI=10.1126/science.278.5338.675; RA Lahn B.T., Page D.C.; RT "Functional coherence of the human Y chromosome."; RL Science 278:675-680(1997). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12815422; DOI=10.1038/nature01722; RA Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., RA Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., RA Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., RA Graves T.A., Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., RA McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., RA Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., RA Waterston R.H., Wilson R.K., Rozen S., Page D.C.; RT "The male-specific region of the human Y chromosome is a mosaic of discrete RT sequence classes."; RL Nature 423:825-837(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Hypothalamus; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Plays an important role in the organization of the CC cytoskeleton. Binds to and sequesters actin monomers (G actin) and CC therefore inhibits actin polymerization (By similarity). {ECO:0000250}. CC -!- INTERACTION: CC O14604; Q9NYB0: TERF2IP; NbExp=2; IntAct=EBI-751196, EBI-750109; CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. CC -!- TISSUE SPECIFICITY: Ubiquitous. CC -!- SIMILARITY: Belongs to the thymosin beta family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF000989; AAC51836.1; -; mRNA. DR EMBL; AC006371; AAD54509.1; -; Genomic_DNA. DR EMBL; BC022482; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; BC119763; AAI19764.1; -; mRNA. DR EMBL; BC119764; AAI19765.1; -; mRNA. DR CCDS; CCDS14786.1; -. DR RefSeq; NP_004193.1; NM_004202.2. DR AlphaFoldDB; O14604; -. DR SMR; O14604; -. DR BioGRID; 114543; 36. DR IntAct; O14604; 34. DR STRING; 9606.ENSP00000284856; -. DR GlyGen; O14604; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; O14604; -. DR PhosphoSitePlus; O14604; -. DR BioMuta; TMSB4Y; -. DR jPOST; O14604; -. DR MassIVE; O14604; -. DR PeptideAtlas; O14604; -. DR ProteomicsDB; 48110; -. DR Antibodypedia; 58313; 37 antibodies from 10 providers. DR DNASU; 9087; -. DR Ensembl; ENST00000284856.4; ENSP00000284856.3; ENSG00000154620.6. DR GeneID; 9087; -. DR KEGG; hsa:9087; -. DR MANE-Select; ENST00000284856.4; ENSP00000284856.3; NM_004202.3; NP_004193.1. DR UCSC; uc004ftb.4; human. DR AGR; HGNC:11882; -. DR CTD; 9087; -. DR DisGeNET; 9087; -. DR GeneCards; TMSB4Y; -. DR HGNC; HGNC:11882; TMSB4Y. DR HPA; ENSG00000154620; Tissue enhanced (intestine). DR MIM; 400017; gene. DR neXtProt; NX_O14604; -. DR OpenTargets; ENSG00000154620; -. DR PharmGKB; PA36582; -. DR VEuPathDB; HostDB:ENSG00000154620; -. DR GeneTree; ENSGT00940000154433; -. DR HOGENOM; CLU_208046_0_0_1; -. DR InParanoid; O14604; -. DR OrthoDB; 4727927at2759; -. DR PhylomeDB; O14604; -. DR PathwayCommons; O14604; -. DR SignaLink; O14604; -. DR BioGRID-ORCS; 9087; 40 hits in 703 CRISPR screens. DR GeneWiki; Thymosin_beta-4,_Y-chromosomal; -. DR GenomeRNAi; 9087; -. DR Pharos; O14604; Tdark. DR PRO; PR:O14604; -. DR Proteomes; UP000005640; Chromosome Y. DR Bgee; ENSG00000154620; Expressed in primordial germ cell in gonad and 82 other cell types or tissues. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. DR GO; GO:0003785; F:actin monomer binding; IBA:GO_Central. DR GO; GO:0007015; P:actin filament organization; IEA:InterPro. DR GO; GO:0008064; P:regulation of actin polymerization or depolymerization; TAS:ProtInc. DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central. DR GO; GO:0042989; P:sequestering of actin monomers; IBA:GO_Central. DR FunFam; 1.20.5.520:FF:000001; Thymosin beta; 1. DR Gene3D; 1.20.5.520; Single helix bin; 1. DR InterPro; IPR001152; Beta-thymosin. DR InterPro; IPR038386; Beta-thymosin_sf. DR PANTHER; PTHR12021; THYMOSIN BETA; 1. DR PANTHER; PTHR12021:SF18; THYMOSIN BETA-4, Y-CHROMOSOMAL; 1. DR Pfam; PF01290; Thymosin; 1. DR PIRSF; PIRSF001828; Thymosin_beta; 1. DR SMART; SM00152; THY; 1. DR PROSITE; PS00500; THYMOSIN_B4; 1. PE 1: Evidence at protein level; KW Actin-binding; Cytoplasm; Cytoskeleton; Proteomics identification; KW Reference proteome. FT CHAIN 1..44 FT /note="Thymosin beta-4, Y-chromosomal" FT /id="PRO_0000045921" FT REGION 1..44 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 44 AA; 5013 MW; 7B336158483A9BE2 CRC64; MSDKPGMAEI EKFDKSKLKK TETQEKNPLS SKETIEQERQ AGES //