ID TYBY_HUMAN STANDARD; PRT; 43 AA. AC O14604; DT 15-JUL-1999 (Rel. 38, Created) DT 15-JUL-1999 (Rel. 38, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Thymosin beta-4, Y-chromosomal. GN TMSB4Y OR TB4Y. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=98022381; PubMed=9381176; RA Lahn B.T., Page D.C.; RT "Functional coherence of the human Y chromosome."; RL Science 278:675-680(1997). CC -!- FUNCTION: EXACT PHYSIOLOGICAL ROLE IS NOT YET KNOWN. THYMIC CC HORMONE THAT INDUCES TERMINAL DEOXYNUCLEOTIDYLTRANSFERASE. CAN CC BIND TO ACTIN MONOMERS AND THUS TO INHIBIT ACTIN POLYMERIZATION CC (BY SIMILARITY). CC -!- SUBCELLULAR LOCATION: Cytoplasmic (By similarity). CC -!- TISSUE SPECIFICITY: UBIQUITOUS. CC -!- SIMILARITY: BELONGS TO THE THYMOSIN BETA FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF000989; AAC51836.1; -. DR MIM; 400017; -. DR InterPro; IPR001152; Thymosin_b4. DR Pfam; PF01290; Thymosin; 1. DR ProDom; PD005116; Thymosin_b4; 1. DR SMART; SM00152; THY; 1. DR PROSITE; PS00500; THYMOSIN_B4; 1. KW T-cell differentiation; Immunopotentiation; Acetylation; Thymus; KW Actin-binding. FT INIT_MET 0 0 BY SIMILARITY. FT MOD_RES 1 1 ACETYLATION (BY SIMILARITY). SQ SEQUENCE 43 AA; 4881 MW; 7B336102870632E2 CRC64; SDKPGMAEIE KFDKSKLKKT ETQEKNPLSS KETIEQERQA GES //