ID   CDK1_HUMAN     STANDARD;      PRT;   115 AA.
AC   O14519;
DT   15-JUL-1999 (Rel. 38, Created)
DT   15-JUL-1999 (Rel. 38, Last sequence update)
DT   29-MAR-2004 (Rel. 43, Last annotation update)
DE   Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated
DE   protein 1) (Putative oral cancer suppressor) (Deleted in oral cancer-
DE   1) (DOC-1).
GN   CDK2AP1 OR CDKAP1 OR DOC1.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=97472613; PubMed=9331572;
RA   Daigo Y., Suzuki K., Maruyama O., Miyoshi Y., Yasuda T., Kabuto T.,
RA   Imaoka S., Fujiwara T., Takahashi E., Fujino M.A., Nakamura Y.;
RT   "Isolation, mapping and mutation analysis of a human cDNA homologous
RT   to the doc-1 gene of the Chinese hamster, a candidate tumor
RT   suppressor for oral cancer.";
RL   Genes Chromosomes Cancer 20:204-207(1997).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Testis;
RX   MEDLINE=98175930; PubMed=9506968;
RA   Tsuji T., Duh F.-M., Latif F., Popescu N.C., Zimonjic D.B.,
RA   McBride J., Matsuo K., Ohyama H., Todd R., Nagata E., Terakado N.,
RA   Sasaki A., Matsumura T., Lerman M.I., Wong D.T.;
RT   "Cloning, mapping, expression, function, and mutation analyses of the
RT   human ortholog of the hamster putative tumor suppressor gene Doc-1.";
RL   J. Biol. Chem. 273:6704-6709(1998).
RN   [3]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Skin;
RX   MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA   Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA   Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length
RT   human and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
CC   -!- SIMILARITY: Belongs to the DOC1 family.
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DR   EMBL; AB006077; BAA22937.1; -.
DR   EMBL; AF006484; AAC77831.1; -.
DR   EMBL; BC034717; AAH34717.1; -.
DR   Genew; HGNC:14002; CDK2AP1.
DR   MIM; 602198; -.
DR   GO; GO:0005737; C:cytoplasm; TAS.
DR   GO; GO:0005634; C:nucleus; TAS.
DR   GO; GO:0003677; F:DNA binding; TAS.
DR   GO; GO:0006261; P:DNA-dependent DNA replication; TAS.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; TAS.
DR   GO; GO:0000084; P:S phase of mitotic cell cycle; TAS.
KW   Anti-oncogene.
SQ   SEQUENCE   115 AA;  12365 MW;  F3149F72467598C2 CRC64;
     MSYKPNLAAH MPAAALNAAG SVHSPSTSMA TSSQYRQLLS DYGPPSLGYT QGTGNSQVPQ
     SKYAELLAII EELGKEIRPT YAGSKSAMER LKRGIIHARG LVRECLAETE RNARS
//