ID ZPR1_SCHPO Reviewed; 459 AA. AC O13724; O74193; DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1998, sequence version 1. DT 08-NOV-2023, entry version 136. DE RecName: Full=Zinc finger chaperone zpr1 {ECO:0000305}; GN Name=zpr1 {ECO:0000312|PomBase:SPAC15A10.04c}; GN ORFNames=SPAC15A10.04c {ECO:0000312|PomBase:SPAC15A10.04c}; OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; OC Schizosaccharomyces. OX NCBI_TaxID=284812; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=9852145; DOI=10.1083/jcb.143.6.1471; RA Gangwani L., Mikrut M., Galcheva-Gargova Z., Davis R.J.; RT "Interaction of ZPR1 with translation elongation factor-1alpha in RT proliferating cells."; RL J. Cell Biol. 143:1471-1484(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=972 / ATCC 24843; RX PubMed=11859360; DOI=10.1038/nature724; RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., RA Nurse P.; RT "The genome sequence of Schizosaccharomyces pombe."; RL Nature 415:871-880(2002). CC -!- FUNCTION: Acts as a protein folding chaperone for elongation factor 1- CC alpha. {ECO:0000250|UniProtKB:P53303}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P53303}. Nucleus CC {ECO:0000250|UniProtKB:P53303}. Note=Translocates to the nucleus after CC nutrient stimulation. {ECO:0000250|UniProtKB:P53303}. CC -!- SIMILARITY: Belongs to the ZPR1 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF019768; AAC33515.1; -; Genomic_DNA. DR EMBL; CU329670; CAB10101.1; -; Genomic_DNA. DR PIR; T37704; T37704. DR PIR; T43538; T43538. DR RefSeq; NP_594291.1; NM_001019714.2. DR AlphaFoldDB; O13724; -. DR SMR; O13724; -. DR STRING; 4896.SPAC15A10.04c.1; -. DR iPTMnet; O13724; -. DR MaxQB; O13724; -. DR PaxDb; 4896-SPAC15A10-04c-1; -. DR EnsemblFungi; SPAC15A10.04c.1; SPAC15A10.04c.1:pep; SPAC15A10.04c. DR GeneID; 2542778; -. DR KEGG; spo:SPAC15A10.04c; -. DR PomBase; SPAC15A10.04c; zpr1. DR VEuPathDB; FungiDB:SPAC15A10.04c; -. DR eggNOG; KOG2703; Eukaryota. DR HOGENOM; CLU_024138_5_0_1; -. DR InParanoid; O13724; -. DR OMA; PVQSQKG; -. DR PhylomeDB; O13724; -. DR PRO; PR:O13724; -. DR Proteomes; UP000002485; Chromosome I. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005829; C:cytosol; HDA:PomBase. DR GO; GO:0005743; C:mitochondrial inner membrane; ISO:PomBase. DR GO; GO:0005634; C:nucleus; HDA:PomBase. DR GO; GO:0044183; F:protein folding chaperone; ISO:PomBase. DR GO; GO:0045182; F:translation regulator activity; ISO:PomBase. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0032543; P:mitochondrial translation; ISO:PomBase. DR GO; GO:0006457; P:protein folding; NAS:PomBase. DR Gene3D; 2.60.120.1040; ZPR1, A/B domain; 2. DR Gene3D; 2.20.25.420; ZPR1, zinc finger domain; 2. DR InterPro; IPR004457; Znf_ZPR1. DR InterPro; IPR040141; ZPR1. DR InterPro; IPR042451; ZPR1_A/B_dom. DR InterPro; IPR042452; ZPR1_Znf1/2. DR NCBIfam; TIGR00310; ZPR1_znf; 2. DR PANTHER; PTHR10876; ZINC FINGER PROTEIN ZPR1; 1. DR PANTHER; PTHR10876:SF0; ZINC FINGER PROTEIN ZPR1; 1. DR Pfam; PF03367; zf-ZPR1; 2. DR SMART; SM00709; Zpr1; 2. PE 3: Inferred from homology; KW Chaperone; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat; KW Zinc; Zinc-finger. FT CHAIN 1..459 FT /note="Zinc finger chaperone zpr1" FT /id="PRO_0000119039" FT ZN_FING 38..70 FT /note="C4-type 1" FT ZN_FING 259..291 FT /note="C4-type 2" FT CONFLICT 88 FT /note="S -> T (in Ref. 1; AAC33515)" FT /evidence="ECO:0000305" FT CONFLICT 367 FT /note="G -> A (in Ref. 1; AAC33515)" FT /evidence="ECO:0000305" SQ SEQUENCE 459 AA; 51377 MW; ED68F7F02BB6F93A CRC64; MAEEKKEELF TSIGNAAQNV STAEDREGNG VQEVESLCME CGKNGTTKLL LTVIPYFREV VLMSFECPHC GFKNAQVQHA ETIQPEGSKI TFHVEDKEDL NRTVVKSQEA IVSIPEIQLE IPGRLGQLTT IEGILSNVVD DLSKEQESRK ESAPQLYDQI NAFIEKVNSL RSGSVPFTIT VDDITGNSWI EMKPGRDGDR WSQVSYKRTL EQNTKLGLVD TDQPEDVKTQ TNNASNTLKH DATAVEVDPN EVHTFHATCP SCSHQCDTHM KLLDIPHFKE VIIMSTVCDR CGYRSNEVKT GGEIPPKGRK ITLKVMDAED LSRDILKSET ASLKIPELGL DLFPGTLGGR FTTIEGLLAQ VYDELYGRVF SQETDSMTPE QVANWQQFLC NLTAAREGAT QFTLILDDPL SQSYLQNYYA PDPDPNMTIE EYERSFQVNE ELGLNDMKTE NYEKDGGKK //