ID MEI4_SCHPO Reviewed; 517 AA. AC O13606; DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1998, sequence version 1. DT 03-MAY-2023, entry version 155. DE RecName: Full=Meiosis-specific transcription factor mei4; GN Name=mei4; ORFNames=pi013, SPBC32H8.11; OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; OC Schizosaccharomyces. OX NCBI_TaxID=284812; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=972 / ATCC 24843; RX PubMed=9528784; DOI=10.1128/mcb.18.4.2118; RA Horie S., Watanabe Y., Tanaka K., Nishiwaki S., Fujioka H., Abe H., RA Yamamoto M., Shimoda C.; RT "The Schizosaccharomyces pombe mei4+ gene encodes a meiosis-specific RT transcription factor containing a forkhead DNA-binding domain."; RL Mol. Cell. Biol. 18:2118-2129(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=972 / ATCC 24843; RX PubMed=10620777; RX DOI=10.1002/(sici)1097-0061(20000115)16:1<71::aid-yea505>3.0.co;2-5; RA Machida M., Yamazaki S., Kunihiro S., Tanaka T., Kushida N., Jinno K., RA Haikawa Y., Yamazaki J., Yamamoto S., Sekine M., Oguchi A., Nagai Y., RA Sakai M., Aoki K., Ogura K., Kudoh Y., Kikuchi H., Zhang M.Q., Yanagida M.; RT "A 38 kb segment containing the cdc2 gene from the left arm of fission RT yeast chromosome II: sequence analysis and characterization of the genomic RT DNA and cDNAs encoded on the segment."; RL Yeast 16:71-80(2000). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=972 / ATCC 24843; RX PubMed=11859360; DOI=10.1038/nature724; RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., RA Nurse P.; RT "The genome sequence of Schizosaccharomyces pombe."; RL Nature 415:871-880(2002). CC -!- FUNCTION: Functions as a meiosis-specific transcription factor. Binds CC to the 5'-GTAAAYA-3' consensus sequence of the promoter of the spo6 CC gene. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB012695; BAA25402.1; -; Genomic_DNA. DR EMBL; AB004534; BAA21390.1; -; Genomic_DNA. DR EMBL; CU329671; CAC37501.1; -; Genomic_DNA. DR PIR; T43358; T43358. DR RefSeq; NP_595617.1; NM_001021512.2. DR AlphaFoldDB; O13606; -. DR SMR; O13606; -. DR BioGRID; 276773; 38. DR DIP; DIP-59802N; -. DR IntAct; O13606; 3. DR STRING; 4896.SPBC32H8.11.1; -. DR iPTMnet; O13606; -. DR PaxDb; O13606; -. DR EnsemblFungi; SPBC32H8.11.1; SPBC32H8.11.1:pep; SPBC32H8.11. DR GeneID; 2540241; -. DR KEGG; spo:SPBC32H8.11; -. DR PomBase; SPBC32H8.11; mei4. DR VEuPathDB; FungiDB:SPBC32H8.11; -. DR eggNOG; KOG2294; Eukaryota. DR HOGENOM; CLU_526931_0_0_1; -. DR InParanoid; O13606; -. DR OMA; TWIRNTF; -. DR Reactome; R-SPO-3232118; SUMOylation of transcription factors. DR Reactome; R-SPO-9018519; Estrogen-dependent gene expression. DR PRO; PR:O13606; -. DR Proteomes; UP000002485; Chromosome II. DR GO; GO:0000785; C:chromatin; IDA:PomBase. DR GO; GO:0005634; C:nucleus; IDA:PomBase. DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:PomBase. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:PomBase. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:PomBase. DR GO; GO:0110044; P:regulation of cell cycle switching, mitotic to meiotic cell cycle; IMP:PomBase. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0010672; P:regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle; IMP:PomBase. DR GO; GO:0110046; P:signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle; IMP:PomBase. DR CDD; cd00059; FH_FOX; 1. DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1. DR InterPro; IPR001766; Fork_head_dom. DR InterPro; IPR030456; TF_fork_head_CS_2. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR PANTHER; PTHR11829:SF343; FORK HEAD DOMAIN-CONTAINING PROTEIN FD3-RELATED; 1. DR PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1. DR Pfam; PF00250; Forkhead; 1. DR PRINTS; PR00053; FORKHEAD. DR SMART; SM00339; FH; 1. DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1. DR PROSITE; PS00658; FORK_HEAD_2; 1. DR PROSITE; PS50039; FORK_HEAD_3; 1. PE 4: Predicted; KW Activator; DNA-binding; Meiosis; Nucleus; Reference proteome; KW Transcription; Transcription regulation. FT CHAIN 1..517 FT /note="Meiosis-specific transcription factor mei4" FT /id="PRO_0000091906" FT DNA_BIND 81..172 FT /note="Fork-head" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089" FT REGION 170..278 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 174..204 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 206..272 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 517 AA; 57685 MW; 05D912F04525C759 CRC64; MVENQGNVEA HGKPKKVILS LSLKESSKIN DSQNVSNVSS KEKCETEALL REENKENLSS DSIRQMIFGD EMAGFVDTGE KPPCSYATLI GLAILQSHNK QLTLSGIYTW IRNTFRYYLN HDGGWQNSIR HNLSLNKAFI KVEKPKGKTL KGHYWTIDPD HMQNFVSVRL HRSHSTDSNS KKRPSSKCHE IKPLTTREIP LARKRSRLNS FNSSTSTSGS SSNVAAEVSN DASQPSNQDS SLNSNIVKPP LPPSNVQSNS SSSENVPKPN AETQEDLPTI DAHESSLYEN VNDSRLYEVP ACRNMALNTG YSDADPGYLR TSFRSNSHNS LPYSANEEED VLQADFLVSQ QSSMVSSYVS SRDPHSMPYY RREPIPLRPS SRFYEYTRPT YGRTDTSCSA PGAFCSTQIN SPSSYINYSK CAPSSPTLSL QKHREHVKSL LYVPDLTPSF DGSDPWNPSS QLLSEPLFDQ HSFQSSLDDL MSVTCFRDSP ELNHESSGYS SAPLMPSNRA FINDFSL //