ID MEI4_SCHPO Reviewed; 517 AA. AC O13606; DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1998, sequence version 1. DT 09-DEC-2015, entry version 115. DE RecName: Full=Meiosis-specific transcription factor mei4; GN Name=mei4; ORFNames=pi013, SPBC32H8.11; OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; OC Schizosaccharomycetes; Schizosaccharomycetales; OC Schizosaccharomycetaceae; Schizosaccharomyces. OX NCBI_TaxID=284812; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=972 / ATCC 24843; RX PubMed=9528784; RA Horie S., Watanabe Y., Tanaka K., Nishiwaki S., Fujioka H., Abe H., RA Yamamoto M., Shimoda C.; RT "The Schizosaccharomyces pombe mei4+ gene encodes a meiosis-specific RT transcription factor containing a forkhead DNA-binding domain."; RL Mol. Cell. Biol. 18:2118-2129(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=972 / ATCC 24843; RX PubMed=10620777; RX DOI=10.1002/(SICI)1097-0061(20000115)16:1<71::AID-YEA505>3.0.CO;2-5; RA Machida M., Yamazaki S., Kunihiro S., Tanaka T., Kushida N., Jinno K., RA Haikawa Y., Yamazaki J., Yamamoto S., Sekine M., Oguchi A., Nagai Y., RA Sakai M., Aoki K., Ogura K., Kudoh Y., Kikuchi H., Zhang M.Q., RA Yanagida M.; RT "A 38 kb segment containing the cdc2 gene from the left arm of fission RT yeast chromosome II: sequence analysis and characterization of the RT genomic DNA and cDNAs encoded on the segment."; RL Yeast 16:71-80(2000). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=972 / ATCC 24843; RX PubMed=11859360; DOI=10.1038/nature724; RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., RA Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., RA Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., RA Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., RA James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., RA Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., RA Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., RA Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., RA Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., RA Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., RA Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., RA Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., RA Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., RA Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., RA Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., RA Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., RA Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., RA Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., RA Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., RA Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., RA Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., RA Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.; RT "The genome sequence of Schizosaccharomyces pombe."; RL Nature 415:871-880(2002). CC -!- FUNCTION: Functions as a meiosis-specific transcription factor. CC Binds to the 5'-GTAAAYA-3' consensus sequence of the promoter of CC the spo6 gene. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- SIMILARITY: Contains 1 fork-head DNA-binding domain. CC {ECO:0000255|PROSITE-ProRule:PRU00089}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB012695; BAA25402.1; -; Genomic_DNA. DR EMBL; AB004534; BAA21390.1; -; Genomic_DNA. DR EMBL; CU329671; CAC37501.1; -; Genomic_DNA. DR PIR; T43358; T43358. DR RefSeq; NP_595617.1; NM_001021512.2. DR ProteinModelPortal; O13606; -. DR SMR; O13606; 80-167. DR BioGrid; 276773; 25. DR DIP; DIP-59802N; -. DR MINT; MINT-4666710; -. DR EnsemblFungi; SPBC32H8.11.1; SPBC32H8.11.1:pep; SPBC32H8.11. DR GeneID; 2540241; -. DR KEGG; spo:SPBC32H8.11; -. DR EuPathDB; FungiDB:SPBC32H8.11; -. DR PomBase; SPBC32H8.11; mei4. DR InParanoid; O13606; -. DR OrthoDB; EOG7647BS; -. DR NextBio; 20801372; -. DR PRO; PR:O13606; -. DR Proteomes; UP000002485; Chromosome II. DR GO; GO:0005634; C:nucleus; IDA:PomBase. DR GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:PomBase. DR GO; GO:0000982; F:transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; IDA:PomBase. DR GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IMP:PomBase. DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central. DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central. DR GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEP:PomBase. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:PomBase. DR GO; GO:0010673; P:positive regulation of transcription from RNA polymerase II promoter during meiosis; IMP:PomBase. DR GO; GO:0006366; P:transcription from RNA polymerase II promoter; IMP:GOC. DR Gene3D; 1.10.10.10; -; 1. DR InterPro; IPR001766; Fork_head_dom. DR InterPro; IPR011991; WHTH_DNA-bd_dom. DR Pfam; PF00250; Forkhead; 1. DR PRINTS; PR00053; FORKHEAD. DR SMART; SM00339; FH; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR PROSITE; PS00658; FORK_HEAD_2; 1. DR PROSITE; PS50039; FORK_HEAD_3; 1. PE 3: Inferred from homology; KW Activator; Complete proteome; DNA-binding; Meiosis; Nucleus; KW Reference proteome; Transcription; Transcription regulation. FT CHAIN 1 517 Meiosis-specific transcription factor FT mei4. FT /FTId=PRO_0000091906. FT DNA_BIND 81 172 Fork-head. {ECO:0000255|PROSITE- FT ProRule:PRU00089}. SQ SEQUENCE 517 AA; 57685 MW; 05D912F04525C759 CRC64; MVENQGNVEA HGKPKKVILS LSLKESSKIN DSQNVSNVSS KEKCETEALL REENKENLSS DSIRQMIFGD EMAGFVDTGE KPPCSYATLI GLAILQSHNK QLTLSGIYTW IRNTFRYYLN HDGGWQNSIR HNLSLNKAFI KVEKPKGKTL KGHYWTIDPD HMQNFVSVRL HRSHSTDSNS KKRPSSKCHE IKPLTTREIP LARKRSRLNS FNSSTSTSGS SSNVAAEVSN DASQPSNQDS SLNSNIVKPP LPPSNVQSNS SSSENVPKPN AETQEDLPTI DAHESSLYEN VNDSRLYEVP ACRNMALNTG YSDADPGYLR TSFRSNSHNS LPYSANEEED VLQADFLVSQ QSSMVSSYVS SRDPHSMPYY RREPIPLRPS SRFYEYTRPT YGRTDTSCSA PGAFCSTQIN SPSSYINYSK CAPSSPTLSL QKHREHVKSL LYVPDLTPSF DGSDPWNPSS QLLSEPLFDQ HSFQSSLDDL MSVTCFRDSP ELNHESSGYS SAPLMPSNRA FINDFSL //