ID O11883_HBV Unreviewed; 154 AA. AC O11883; DT 01-JUL-1997, integrated into UniProtKB/TrEMBL. DT 01-JUL-1997, sequence version 1. DT 29-OCT-2014, entry version 55. DE RecName: Full=Protein X {ECO:0000256|RuleBase:RU361181, ECO:0000256|SAAS:SAAS00140604}; DE AltName: Full=HBx {ECO:0000256|RuleBase:RU361181}; DE AltName: Full=Peptide X {ECO:0000256|RuleBase:RU361181}; DE AltName: Full=pX {ECO:0000256|RuleBase:RU361181}; GN Name=X {ECO:0000313|EMBL:AGA16743.1}; OS Hepatitis B virus (HBV). OC Viruses; Retro-transcribing viruses; Hepadnaviridae; OC Orthohepadnavirus. OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AAB59970.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee). RN [1] {ECO:0000313|EMBL:AAB59970.1} RP NUCLEOTIDE SEQUENCE. RA Rao B.S., Casey J.L., Rinaudo J.S., Korba B.E.; RT "Complete nucleotide sequence of a molecular clone of hepatitis B RT virus from the 2.2.15 cell line."; RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:BAE93198.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Toshima 1 {ECO:0000313|EMBL:BAE93198.1}; RX PubMed=17191017; DOI=10.1159/000098241; RA Michitaka K., Horiike N., Duong T.N., Yagura M., Harada H., RA Shibayama T., Inui A., Fujisawa T., Matsuura K., Hiasa Y., Onji M.; RT "Heterogeneity of hepatitis B virus genotype D in Japan."; RL Intervirology 50:150-155(2007). RN [3] {ECO:0000313|EMBL:AGA16743.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=P11 {ECO:0000313|EMBL:AGA16743.1}, P16 RC {ECO:0000313|EMBL:AGA16771.1}, P17 {ECO:0000313|EMBL:AGA16778.1}, P19 RC {ECO:0000313|EMBL:AGA16785.1}, P24 {ECO:0000313|EMBL:AGA16799.1}, and RC P29 {ECO:0000313|EMBL:AGA16764.1}; RA Alestig E.; RT "Genetic diversity of genotype D3 in acute hepatitis B."; RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Multifunctional protein that may modulate protein CC degradation pathways, apoptosis, transcription, signal CC transduction, cell cycle progress, and genetic stability by CC directly or indirectly interacting with host factors. CC {ECO:0000256|RuleBase:RU361181}. CC -!- SUBUNIT: May form homodimer. {ECO:0000256|RuleBase:RU361181}. CC -!- SUBCELLULAR LOCATION: Host cytoplasm CC {ECO:0000256|RuleBase:RU361181, ECO:0000256|SAAS:SAAS00140596}. CC Host nucleus {ECO:0000256|RuleBase:RU361181, CC ECO:0000256|SAAS:SAAS00140596}. Host mitochondrion CC {ECO:0000256|RuleBase:RU361181, ECO:0000256|SAAS:SAAS00140596}. CC -!- SIMILARITY: Belongs to the orthohepadnavirus protein X family. CC {ECO:0000256|RuleBase:RU361181}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U95551; AAB59970.1; -; Genomic_DNA. DR EMBL; JX898686; AGA16743.1; -; Genomic_DNA. DR EMBL; JX898689; AGA16764.1; -; Genomic_DNA. DR EMBL; JX898690; AGA16771.1; -; Genomic_DNA. DR EMBL; JX898691; AGA16778.1; -; Genomic_DNA. DR EMBL; JX898692; AGA16785.1; -; Genomic_DNA. DR EMBL; JX898694; AGA16799.1; -; Genomic_DNA. DR EMBL; AB210819; BAE93198.1; -; Genomic_DNA. DR GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0039652; P:activation by virus of host NF-kappaB transcription factor activity; IEA:UniProtKB-KW. DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. DR GO; GO:0039592; P:suppression by virus of G2/M transition of host mitotic cell cycle; IEA:UniProtKB-KW. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW. DR GO; GO:0019079; P:viral genome replication; IEA:InterPro. DR InterPro; IPR000236; Transactivation_prot_X. DR Pfam; PF00739; X; 1. PE 3: Inferred from homology; KW Activation of host NF-kappa-B by virus KW {ECO:0000256|SAAS:SAAS00140606}; KW Activator {ECO:0000256|SAAS:SAAS00140602}; KW Apoptosis {ECO:0000256|SAAS:SAAS00140607}; KW Host cytoplasm {ECO:0000256|RuleBase:RU361181, KW ECO:0000256|SAAS:SAAS00140618}; KW Host G2/M cell cycle arrest by virus {ECO:0000256|SAAS:SAAS00140597}; KW Host mitochondrion {ECO:0000256|RuleBase:RU361181, KW ECO:0000256|SAAS:SAAS00140593}; KW Host nucleus {ECO:0000256|RuleBase:RU361181, KW ECO:0000256|SAAS:SAAS00140595}; KW Host-virus interaction {ECO:0000256|RuleBase:RU361181, KW ECO:0000256|SAAS:SAAS00140619}; KW Modulation of host cell cycle by virus KW {ECO:0000256|SAAS:SAAS00140594}; KW Transcription {ECO:0000256|SAAS:SAAS00140620}; KW Transcription regulation {ECO:0000256|SAAS:SAAS00140605}. SQ SEQUENCE 154 AA; 16611 MW; 895800BDF24CEA17 CRC64; MAARLCCQLD PARDVLCLRP VGAESCGRPF SGSLGTLSSP SPSAVPTDHG AHLSLRGLPV CAFSSAGPCA LRFTSARRME TTVNAHRMLP KVLHKRTLGL SAMSTTDLEA YFKDCLFKDW EELGEEIRLK VFVLGGCRHK LVCAPAPCNF FTSA //