ID GATA2_MOUSE Reviewed; 480 AA. AC O09100; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 27-MAY-2002, sequence version 2. DT 27-JUL-2011, entry version 82. DE RecName: Full=Endothelial transcription factor GATA-2; DE AltName: Full=GATA-binding protein 2; GN Name=Gata2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Liver; RA Suwabe N., Minegishi N., Yamamoto M.; RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases. RN [2] RP GENOMIC ORGANIZATION. RX MEDLINE=98123142; PubMed=9452491; DOI=10.1074/jbc.273.6.3625; RA Minegishi N., Ohta J., Suwabe N., Nakauchi H., Ishihara H., RA Hayashi N., Yamamoto M.; RT "Alternative promoters regulate transcription of the mouse GATA-2 RT gene."; RL J. Biol. Chem. 273:3625-3634(1998). CC -!- FUNCTION: Transcriptional activator which regulates endothelin-1 CC gene expression in endothelial cells. Binds to the consensus CC sequence 5'-AGATAG-3'. CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- SIMILARITY: Contains 2 GATA-type zinc fingers. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB000096; BAA19053.2; -; mRNA. DR IPI; IPI00114226; -. DR RefSeq; NP_032116.4; NM_008090.5. DR UniGene; Mm.272747; -. DR ProteinModelPortal; O09100; -. DR SMR; O09100; 291-329, 343-398. DR STRING; O09100; -. DR PhosphoSite; O09100; -. DR PRIDE; O09100; -. DR Ensembl; ENSMUST00000015197; ENSMUSP00000015197; ENSMUSG00000015053. DR Ensembl; ENSMUST00000170089; ENSMUSP00000128198; ENSMUSG00000015053. DR GeneID; 14461; -. DR KEGG; mmu:14461; -. DR CTD; 2624; -. DR MGI; MGI:95662; Gata2. DR eggNOG; roNOG07682; -. DR HOGENOM; HBG716943; -. DR HOVERGEN; HBG051705; -. DR InParanoid; O09100; -. DR OMA; MEPMAPL; -. DR OrthoDB; EOG4S1T85; -. DR ArrayExpress; O09100; -. DR Bgee; O09100; -. DR CleanEx; MM_GATA2; -. DR Genevestigator; O09100; -. DR GermOnline; ENSMUSG00000015053; Mus musculus. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0005515; F:protein binding; IPI:BHF-UCL. DR GO; GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:MGI. DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0001709; P:cell fate determination; IDA:MGI. DR GO; GO:0048469; P:cell maturation; IMP:MGI. DR GO; GO:0060216; P:definitive hemopoiesis; IMP:MGI. DR GO; GO:0001892; P:embryonic placenta development; IMP:MGI. DR GO; GO:0030182; P:neuron differentiation; IMP:MGI. DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW. DR GO; GO:0021983; P:pituitary gland development; IMP:MGI. DR GO; GO:0045766; P:positive regulation of angiogenesis; IMP:MGI. DR GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB. DR GO; GO:0001655; P:urogenital system development; IMP:MGI. DR InterPro; IPR016374; TF_GATA-1/2/3. DR InterPro; IPR000679; Znf_GATA. DR InterPro; IPR013088; Znf_NHR/GATA. DR Gene3D; G3DSA:3.30.50.10; Znf_NHR/GATA; 2. DR Pfam; PF00320; GATA; 2. DR PIRSF; PIRSF003027; TF_GATA-1/2/3; 1. DR PRINTS; PR00619; GATAZNFINGER. DR SMART; SM00401; ZnF_GATA; 2. DR PROSITE; PS00344; GATA_ZN_FINGER_1; 2. DR PROSITE; PS50114; GATA_ZN_FINGER_2; 2. PE 2: Evidence at transcript level; KW Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus; KW Phagocytosis; Repeat; Transcription; Transcription regulation; Zinc; KW Zinc-finger. FT CHAIN 1 480 Endothelial transcription factor GATA-2. FT /FTId=PRO_0000083404. FT ZN_FING 295 319 GATA-type 1. FT ZN_FING 349 373 GATA-type 2. SQ SEQUENCE 480 AA; 50468 MW; 7E0DCE9B53F49C8A CRC64; MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHSPWTVSP FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASSSAGG SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLATMGTQP ATHHPIPTYP SYVPAAAHDY GSSLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SSKSKKSKKG AECFEELSKC MQEKSPPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG //