ID GAT2_MOUSE STANDARD; PRT; 480 AA. AC O09100; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 15-JUL-1999 (Rel. 38, Last annotation update) DE ENDOTHELIAL TRANSCRIPTION FACTOR GATA-2. GN GATA2. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; OC Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=LIVER; RA SUWABE N., MINEGISHI N., YAMAMOTO M.; RL Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 98123142. RA MINEGISHI N., OHTA J., SUWABE N., NAKAUCHI H., ISHIHARA H., RA HAYASHI N., YAMAMOTO M.; RT "Alternative promoters regulate transcription of the mouse GATA-2 RT gene."; RL J. Biol. Chem. 273:3625-3634(1998). CC -!- FUNCTION: TRANSCRIPTIONAL ACTIVATOR WHICH REGULATES ENDOTHELIN-1 CC GENE EXPRESSION IN ENDOTHELIAL CELLS. BINDS TO THE CONSENSUS CC SEQUENCE 5'-AGATAG-3'. CC -!- SUBCELLULAR LOCATION: NUCLEAR. CC -!- SIMILARITY: BELONGS TO THE GATA-TYPE TRANSCRIPTION FACTOR FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB000096; BAA19053.1; -. DR HSSP; P17678; 1GAU. DR MGD; MGI:95662; GATA2. DR PFAM; PF00320; GATA; 2. DR PROSITE; PS00344; GATA_ZN_FINGER; 2. KW Transcription regulation; Activator; DNA-binding; Zinc-finger; KW Nuclear protein. FT ZN_FING 295 319 GATA-TYPE. FT ZN_FING 349 373 GATA-TYPE. SQ SEQUENCE 480 AA; 50450 MW; 600E7988 CRC32; MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHSPWTVSP FSKTPLHPSA AGAPGGPLSV YPGSAGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASSSAGG SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLATMGTQP ATHHPIPTYP SYVPAAAHDY GSSLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SSKSKKSKKG AECFEELSKC MQEKSPPFSA AALAGHMAPV GHLPPLSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG //