ID GATA2_MOUSE STANDARD; PRT; 480 AA. AC O09100; DT 01-NOV-1997 (Rel. 35, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 01-MAY-2005 (Rel. 47, Last annotation update) DE Endothelial transcription factor GATA-2. GN Name=Gata2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Liver; RA Suwabe N., Minegishi N., Yamamoto M.; RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases. RN [2] RP GENOMIC ORGANIZATION. RX MEDLINE=98123142; PubMed=9452491; DOI=10.1074/jbc.273.6.3625; RA Minegishi N., Ohta J., Suwabe N., Nakauchi H., Ishihara H., RA Hayashi N., Yamamoto M.; RT "Alternative promoters regulate transcription of the mouse GATA-2 RT gene."; RL J. Biol. Chem. 273:3625-3634(1998). CC -!- FUNCTION: Transcriptional activator which regulates endothelin-1 CC gene expression in endothelial cells. Binds to the consensus CC sequence 5'-AGATAG-3'. CC -!- SUBCELLULAR LOCATION: Nuclear. CC -!- SIMILARITY: Contains 2 GATA-type zinc fingers. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB000096; BAA19053.2; -. DR HSSP; P17679; 1GNF. DR TRANSFAC; T01302; -. DR Ensembl; ENSMUSG00000015053; Mus musculus. DR MGD; MGI:95662; Gata2. DR GO; GO:0003677; F:DNA binding; IDA. DR GO; GO:0030182; P:neuron differentiation; IMP. DR InterPro; IPR000679; Znf_GATA. DR Pfam; PF00320; GATA; 2. DR PRINTS; PR00619; GATAZNFINGER. DR SMART; SM00401; ZnF_GATA; 2. DR PROSITE; PS00344; GATA_ZN_FINGER_1; 2. DR PROSITE; PS50114; GATA_ZN_FINGER_2; 2. KW Activator; DNA-binding; Nuclear protein; Transcription; KW Transcription regulation; Zinc-finger. FT ZN_FING 295 319 GATA-type 1. FT ZN_FING 349 373 GATA-type 2. SQ SEQUENCE 480 AA; 50468 MW; 7E0DCE9B53F49C8A CRC64; MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHSPWTVSP FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASSSAGG SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLATMGTQP ATHHPIPTYP SYVPAAAHDY GSSLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SSKSKKSKKG AECFEELSKC MQEKSPPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG //