ID GATA2_MOUSE Reviewed; 480 AA. AC O09100; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 27-MAY-2002, sequence version 2. DT 24-JAN-2024, entry version 172. DE RecName: Full=Endothelial transcription factor GATA-2; DE AltName: Full=GATA-binding protein 2; GN Name=Gata2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Liver; RA Suwabe N., Minegishi N., Yamamoto M.; RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases. RN [2] RP GENOMIC ORGANIZATION. RX PubMed=9452491; DOI=10.1074/jbc.273.6.3625; RA Minegishi N., Ohta J., Suwabe N., Nakauchi H., Ishihara H., Hayashi N., RA Yamamoto M.; RT "Alternative promoters regulate transcription of the mouse GATA-2 gene."; RL J. Biol. Chem. 273:3625-3634(1998). RN [3] RP INTERACTION WITH BRD3. RX PubMed=21536911; DOI=10.1073/pnas.1102140108; RA Lamonica J.M., Deng W., Kadauke S., Campbell A.E., Gamsjaeger R., Wang H., RA Cheng Y., Billin A.N., Hardison R.C., Mackay J.P., Blobel G.A.; RT "Bromodomain protein Brd3 associates with acetylated GATA1 to promote its RT chromatin occupancy at erythroid target genes."; RL Proc. Natl. Acad. Sci. U.S.A. 108:E159-E168(2011). RN [4] RP INTERACTION WITH MDFIC. RX PubMed=35235341; DOI=10.1126/scitranslmed.abm4869; RA Byrne A.B., Brouillard P., Sutton D.L., Kazenwadel J., RA Montazaribarforoushi S., Secker G.A., Oszmiana A., Babic M., RA Betterman K.L., Brautigan P.J., White M., Piltz S.G., Thomas P.Q., RA Hahn C.N., Rath M., Felbor U., Korenke G.C., Smith C.L., Wood K.H., RA Sheppard S.E., Adams D.M., Kariminejad A., Helaers R., Boon L.M., RA Revencu N., Moore L., Barnett C., Haan E., Arts P., Vikkula M., Scott H.S., RA Harvey N.L.; RT "Pathogenic variants in MDFIC cause recessive central conducting lymphatic RT anomaly with lymphedema."; RL Sci. Transl. Med. 14:eabm4869-eabm4869(2022). CC -!- FUNCTION: Transcriptional activator which regulates endothelin-1 gene CC expression in endothelial cells. Binds to the consensus sequence 5'- CC AGATAG-3'. CC -!- SUBUNIT: Interacts with BRD3. Interacts with AR and CCAR1 (By CC similarity). Interacts with MDFIC (PubMed:35235341). CC {ECO:0000250|UniProtKB:P23769, ECO:0000269|PubMed:21536911, CC ECO:0000269|PubMed:35235341}. CC -!- SUBCELLULAR LOCATION: Nucleus. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB000096; BAA19053.2; -; mRNA. DR CCDS; CCDS20333.1; -. DR RefSeq; NP_032116.4; NM_008090.5. DR RefSeq; XP_006505602.1; XM_006505539.3. DR AlphaFoldDB; O09100; -. DR SMR; O09100; -. DR BioGRID; 199839; 3. DR CORUM; O09100; -. DR STRING; 10090.ENSMUSP00000015197; -. DR iPTMnet; O09100; -. DR PhosphoSitePlus; O09100; -. DR PaxDb; 10090-ENSMUSP00000015197; -. DR ProteomicsDB; 267565; -. DR ABCD; O09100; 28 sequenced antibodies. DR Antibodypedia; 788; 528 antibodies from 37 providers. DR DNASU; 14461; -. DR Ensembl; ENSMUST00000015197.9; ENSMUSP00000015197.8; ENSMUSG00000015053.15. DR Ensembl; ENSMUST00000170089.8; ENSMUSP00000128198.2; ENSMUSG00000015053.15. DR GeneID; 14461; -. DR KEGG; mmu:14461; -. DR UCSC; uc009cvc.2; mouse. DR AGR; MGI:95662; -. DR CTD; 2624; -. DR MGI; MGI:95662; Gata2. DR VEuPathDB; HostDB:ENSMUSG00000015053; -. DR eggNOG; KOG1601; Eukaryota. DR GeneTree; ENSGT00940000156315; -. DR HOGENOM; CLU_027524_1_0_1; -. DR InParanoid; O09100; -. DR OMA; AVYPCGS; -. DR OrthoDB; 685518at2759; -. DR PhylomeDB; O09100; -. DR TreeFam; TF315391; -. DR Reactome; R-MMU-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs. DR Reactome; R-MMU-983231; Factors involved in megakaryocyte development and platelet production. DR BioGRID-ORCS; 14461; 8 hits in 78 CRISPR screens. DR ChiTaRS; Gata2; mouse. DR PRO; PR:O09100; -. DR Proteomes; UP000000589; Chromosome 6. DR RNAct; O09100; Protein. DR Bgee; ENSMUSG00000015053; Expressed in seminal vesicle and 239 other cell types or tissues. DR ExpressionAtlas; O09100; baseline and differential. DR Genevisible; O09100; MM. DR GO; GO:0005737; C:cytoplasm; ISO:MGI. DR GO; GO:0005654; C:nucleoplasm; ISO:MGI. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0005667; C:transcription regulator complex; IDA:MGI. DR GO; GO:0070742; F:C2H2 zinc finger domain binding; ISO:MGI. DR GO; GO:0003682; F:chromatin binding; IDA:MGI. DR GO; GO:0003677; F:DNA binding; IDA:MGI. DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:MGI. DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISO:MGI. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:MGI. DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; ISO:MGI. DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI. DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI. DR GO; GO:0001223; F:transcription coactivator binding; IPI:BHF-UCL. DR GO; GO:0001221; F:transcription coregulator binding; ISO:MGI. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0001525; P:angiogenesis; IMP:MGI. DR GO; GO:0050873; P:brown fat cell differentiation; IMP:MGI. DR GO; GO:0021533; P:cell differentiation in hindbrain; IMP:MGI. DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central. DR GO; GO:0001709; P:cell fate determination; IDA:MGI. DR GO; GO:0021954; P:central nervous system neuron development; IMP:MGI. DR GO; GO:0090102; P:cochlea development; IEA:Ensembl. DR GO; GO:0021902; P:commitment of neuronal cell to specific neuron type in forebrain; IMP:MGI. DR GO; GO:0060216; P:definitive hemopoiesis; IMP:MGI. DR GO; GO:0001892; P:embryonic placenta development; IMP:MGI. DR GO; GO:0035854; P:eosinophil fate commitment; ISO:MGI. DR GO; GO:0045444; P:fat cell differentiation; ISO:MGI. DR GO; GO:0097154; P:GABAergic neuron differentiation; IMP:MGI. DR GO; GO:0002067; P:glandular epithelial cell differentiation; IMP:MGI. DR GO; GO:0002071; P:glandular epithelial cell maturation; IMP:MGI. DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IMP:MGI. DR GO; GO:0061484; P:hematopoietic stem cell homeostasis; IMP:MGI. DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IMP:MGI. DR GO; GO:0042472; P:inner ear morphogenesis; IMP:MGI. DR GO; GO:0030099; P:myeloid cell differentiation; IMP:MGI. DR GO; GO:1903444; P:negative regulation of brown fat cell differentiation; IMP:MGI. DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; ISO:MGI. DR GO; GO:0010629; P:negative regulation of gene expression; ISO:MGI. DR GO; GO:1901533; P:negative regulation of hematopoietic progenitor cell differentiation; IMP:MGI. DR GO; GO:0045650; P:negative regulation of macrophage differentiation; IDA:MGI. DR GO; GO:0045638; P:negative regulation of myeloid cell differentiation; IMP:MGI. DR GO; GO:2000178; P:negative regulation of neural precursor cell proliferation; ISO:MGI. DR GO; GO:0007406; P:negative regulation of neuroblast proliferation; IMP:MGI. DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; ISO:MGI. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI. DR GO; GO:0061351; P:neural precursor cell proliferation; IMP:MGI. DR GO; GO:0007405; P:neuroblast proliferation; IMP:MGI. DR GO; GO:0061101; P:neuroendocrine cell differentiation; IMP:MGI. DR GO; GO:0030182; P:neuron differentiation; IMP:MGI. DR GO; GO:0048663; P:neuron fate commitment; IMP:MGI. DR GO; GO:0042551; P:neuron maturation; IMP:MGI. DR GO; GO:0001764; P:neuron migration; ISO:MGI. DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW. DR GO; GO:0021983; P:pituitary gland development; IMP:MGI. DR GO; GO:0045766; P:positive regulation of angiogenesis; IMP:MGI. DR GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; ISO:MGI. DR GO; GO:1903589; P:positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; ISO:MGI. DR GO; GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; ISO:MGI. DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI. DR GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IDA:MGI. DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI. DR GO; GO:0043306; P:positive regulation of mast cell degranulation; ISO:MGI. DR GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; IDA:MGI. DR GO; GO:1902895; P:positive regulation of miRNA transcription; ISO:MGI. DR GO; GO:0045666; P:positive regulation of neuron differentiation; ISO:MGI. DR GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB. DR GO; GO:0060100; P:positive regulation of phagocytosis, engulfment; ISO:MGI. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI. DR GO; GO:2000977; P:regulation of forebrain neuron differentiation; IMP:MGI. DR GO; GO:0035065; P:regulation of histone acetylation; IDA:MGI. DR GO; GO:0010725; P:regulation of primitive erythrocyte differentiation; IGI:MGI. DR GO; GO:0033993; P:response to lipid; IEA:Ensembl. DR GO; GO:0060872; P:semicircular canal development; IMP:MGI. DR GO; GO:0035019; P:somatic stem cell population maintenance; IMP:MGI. DR GO; GO:0060129; P:thyroid-stimulating hormone-secreting cell differentiation; IMP:MGI. DR GO; GO:0006366; P:transcription by RNA polymerase II; IMP:MGI. DR GO; GO:0001655; P:urogenital system development; IMP:MGI. DR GO; GO:0061042; P:vascular wound healing; ISO:MGI. DR GO; GO:0021514; P:ventral spinal cord interneuron differentiation; IMP:MGI. DR CDD; cd00202; ZnF_GATA; 2. DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 2. DR InterPro; IPR016374; TF_GATA-2/3. DR InterPro; IPR039355; Transcription_factor_GATA. DR InterPro; IPR000679; Znf_GATA. DR InterPro; IPR013088; Znf_NHR/GATA. DR PANTHER; PTHR10071:SF149; ENDOTHELIAL TRANSCRIPTION FACTOR GATA-2; 1. DR PANTHER; PTHR10071; TRANSCRIPTION FACTOR GATA FAMILY MEMBER; 1. DR Pfam; PF00320; GATA; 2. DR PIRSF; PIRSF003027; TF_GATA-1/2/3; 1. DR PRINTS; PR00619; GATAZNFINGER. DR SMART; SM00401; ZnF_GATA; 2. DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2. DR PROSITE; PS00344; GATA_ZN_FINGER_1; 2. DR PROSITE; PS50114; GATA_ZN_FINGER_2; 2. PE 1: Evidence at protein level; KW Activator; DNA-binding; Isopeptide bond; Metal-binding; Methylation; KW Nucleus; Phagocytosis; Phosphoprotein; Reference proteome; Repeat; KW Transcription; Transcription regulation; Ubl conjugation; Zinc; KW Zinc-finger. FT CHAIN 1..480 FT /note="Endothelial transcription factor GATA-2" FT /id="PRO_0000083404" FT ZN_FING 295..319 FT /note="GATA-type 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094" FT ZN_FING 349..373 FT /note="GATA-type 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094" FT REGION 166..208 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 457..480 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 183..199 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 457..471 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 73 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P23769" FT MOD_RES 86 FT /note="Asymmetric dimethylarginine" FT /evidence="ECO:0000250|UniProtKB:P23769" FT MOD_RES 192 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P23769" FT CROSSLNK 389 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0000250|UniProtKB:P23769" SQ SEQUENCE 480 AA; 50468 MW; 7E0DCE9B53F49C8A CRC64; MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHSPWTVSP FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASSSAGG SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLATMGTQP ATHHPIPTYP SYVPAAAHDY GSSLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SSKSKKSKKG AECFEELSKC MQEKSPPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG //