ID GATA2_MOUSE Reviewed; 480 AA. AC O09100; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 27-MAY-2002, sequence version 2. DT 31-JAN-2018, entry version 136. DE RecName: Full=Endothelial transcription factor GATA-2; DE AltName: Full=GATA-binding protein 2; GN Name=Gata2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Liver; RA Suwabe N., Minegishi N., Yamamoto M.; RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases. RN [2] RP GENOMIC ORGANIZATION. RX PubMed=9452491; DOI=10.1074/jbc.273.6.3625; RA Minegishi N., Ohta J., Suwabe N., Nakauchi H., Ishihara H., RA Hayashi N., Yamamoto M.; RT "Alternative promoters regulate transcription of the mouse GATA-2 RT gene."; RL J. Biol. Chem. 273:3625-3634(1998). RN [3] RP INTERACTION WITH BRD3. RX PubMed=21536911; DOI=10.1073/pnas.1102140108; RA Lamonica J.M., Deng W., Kadauke S., Campbell A.E., Gamsjaeger R., RA Wang H., Cheng Y., Billin A.N., Hardison R.C., Mackay J.P., RA Blobel G.A.; RT "Bromodomain protein Brd3 associates with acetylated GATA1 to promote RT its chromatin occupancy at erythroid target genes."; RL Proc. Natl. Acad. Sci. U.S.A. 108:E159-E168(2011). CC -!- FUNCTION: Transcriptional activator which regulates endothelin-1 CC gene expression in endothelial cells. Binds to the consensus CC sequence 5'-AGATAG-3'. CC -!- SUBUNIT: Interacts with BRD3. Interacts with AR and CCAR1 (By CC similarity). {ECO:0000250|UniProtKB:P23769, CC ECO:0000269|PubMed:21536911}. CC -!- SUBCELLULAR LOCATION: Nucleus. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB000096; BAA19053.2; -; mRNA. DR CCDS; CCDS20333.1; -. DR RefSeq; NP_032116.4; NM_008090.5. DR RefSeq; XP_006505602.1; XM_006505539.3. DR UniGene; Mm.491156; -. DR ProteinModelPortal; O09100; -. DR SMR; O09100; -. DR BioGrid; 199839; 3. DR CORUM; O09100; -. DR STRING; 10090.ENSMUSP00000015197; -. DR iPTMnet; O09100; -. DR PhosphoSitePlus; O09100; -. DR PaxDb; O09100; -. DR PRIDE; O09100; -. DR Ensembl; ENSMUST00000015197; ENSMUSP00000015197; ENSMUSG00000015053. DR Ensembl; ENSMUST00000170089; ENSMUSP00000128198; ENSMUSG00000015053. DR GeneID; 14461; -. DR KEGG; mmu:14461; -. DR UCSC; uc009cvc.2; mouse. DR CTD; 2624; -. DR MGI; MGI:95662; Gata2. DR eggNOG; KOG1601; Eukaryota. DR eggNOG; COG5641; LUCA. DR GeneTree; ENSGT00760000119221; -. DR HOGENOM; HOG000047701; -. DR HOVERGEN; HBG051705; -. DR InParanoid; O09100; -. DR KO; K17894; -. DR OMA; PRWMAHH; -. DR OrthoDB; EOG091G0AUR; -. DR PhylomeDB; O09100; -. DR TreeFam; TF315391; -. DR Reactome; R-MMU-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs. DR Reactome; R-MMU-983231; Factors involved in megakaryocyte development and platelet production. DR PRO; PR:O09100; -. DR Proteomes; UP000000589; Chromosome 6. DR Bgee; ENSMUSG00000015053; -. DR CleanEx; MM_GATA2; -. DR ExpressionAtlas; O09100; baseline and differential. DR Genevisible; O09100; MM. DR GO; GO:0005654; C:nucleoplasm; ISO:MGI. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0043234; C:protein complex; IDA:MGI. DR GO; GO:0005667; C:transcription factor complex; IBA:GO_Central. DR GO; GO:0070742; F:C2H2 zinc finger domain binding; ISO:MGI. DR GO; GO:0003682; F:chromatin binding; IDA:MGI. DR GO; GO:0003677; F:DNA binding; IDA:MGI. DR GO; GO:0003700; F:DNA binding transcription factor activity; ISO:MGI. DR GO; GO:0001158; F:enhancer sequence-specific DNA binding; ISO:MGI. DR GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IDA:MGI. DR GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IDA:MGI. DR GO; GO:0001085; F:RNA polymerase II transcription factor binding; IBA:GO_Central. DR GO; GO:0008134; F:transcription factor binding; ISO:MGI. DR GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IDA:MGI. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0030154; P:cell differentiation; IMP:MGI. DR GO; GO:0021533; P:cell differentiation in hindbrain; IMP:MGI. DR GO; GO:0001709; P:cell fate determination; IDA:MGI. DR GO; GO:0048469; P:cell maturation; IMP:MGI. DR GO; GO:0021954; P:central nervous system neuron development; IMP:MGI. DR GO; GO:0090102; P:cochlea development; IEA:Ensembl. DR GO; GO:0021902; P:commitment of neuronal cell to specific neuron type in forebrain; IMP:MGI. DR GO; GO:0060216; P:definitive hemopoiesis; IMP:MGI. DR GO; GO:0001892; P:embryonic placenta development; IMP:MGI. DR GO; GO:0035854; P:eosinophil fate commitment; ISO:MGI. DR GO; GO:0097154; P:GABAergic neuron differentiation; IMP:MGI. DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IMP:MGI. DR GO; GO:0042472; P:inner ear morphogenesis; IMP:MGI. DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IEA:Ensembl. DR GO; GO:0045599; P:negative regulation of fat cell differentiation; IMP:MGI. DR GO; GO:0070345; P:negative regulation of fat cell proliferation; ISO:MGI. DR GO; GO:0045650; P:negative regulation of macrophage differentiation; IDA:MGI. DR GO; GO:0045638; P:negative regulation of myeloid cell differentiation; IMP:MGI. DR GO; GO:2000178; P:negative regulation of neural precursor cell proliferation; IMP:MGI. DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; ISO:MGI. DR GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI. DR GO; GO:0030182; P:neuron differentiation; IMP:MGI. DR GO; GO:0048663; P:neuron fate commitment; IMP:MGI. DR GO; GO:0001764; P:neuron migration; IEA:Ensembl. DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW. DR GO; GO:0021983; P:pituitary gland development; IMP:MGI. DR GO; GO:0045766; P:positive regulation of angiogenesis; IMP:MGI. DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl. DR GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IDA:MGI. DR GO; GO:0043306; P:positive regulation of mast cell degranulation; IEA:Ensembl. DR GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; IDA:MGI. DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl. DR GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB. DR GO; GO:0060100; P:positive regulation of phagocytosis, engulfment; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. DR GO; GO:2000977; P:regulation of forebrain neuron differentiation; IMP:MGI. DR GO; GO:0035065; P:regulation of histone acetylation; IDA:MGI. DR GO; GO:0010725; P:regulation of primitive erythrocyte differentiation; IGI:MGI. DR GO; GO:0033993; P:response to lipid; IEA:Ensembl. DR GO; GO:0060872; P:semicircular canal development; IMP:MGI. DR GO; GO:0035019; P:somatic stem cell population maintenance; IMP:MGI. DR GO; GO:0006351; P:transcription, DNA-templated; ISO:MGI. DR GO; GO:0001655; P:urogenital system development; IMP:MGI. DR GO; GO:0021514; P:ventral spinal cord interneuron differentiation; IMP:MGI. DR Gene3D; 3.30.50.10; -; 1. DR InterPro; IPR029522; GATA-2. DR InterPro; IPR016374; TF_GATA-2/3. DR InterPro; IPR000679; Znf_GATA. DR InterPro; IPR013088; Znf_NHR/GATA. DR PANTHER; PTHR10071:SF149; PTHR10071:SF149; 1. DR Pfam; PF00320; GATA; 2. DR PIRSF; PIRSF003027; TF_GATA-1/2/3; 1. DR PRINTS; PR00619; GATAZNFINGER. DR SMART; SM00401; ZnF_GATA; 2. DR PROSITE; PS00344; GATA_ZN_FINGER_1; 2. DR PROSITE; PS50114; GATA_ZN_FINGER_2; 2. PE 1: Evidence at protein level; KW Activator; Complete proteome; DNA-binding; Isopeptide bond; KW Metal-binding; Methylation; Nucleus; Phagocytosis; Phosphoprotein; KW Reference proteome; Repeat; Transcription; Transcription regulation; KW Ubl conjugation; Zinc; Zinc-finger. FT CHAIN 1 480 Endothelial transcription factor GATA-2. FT /FTId=PRO_0000083404. FT ZN_FING 295 319 GATA-type 1. {ECO:0000255|PROSITE- FT ProRule:PRU00094}. FT ZN_FING 349 373 GATA-type 2. {ECO:0000255|PROSITE- FT ProRule:PRU00094}. FT MOD_RES 73 73 Phosphoserine. FT {ECO:0000250|UniProtKB:P23769}. FT MOD_RES 86 86 Asymmetric dimethylarginine. FT {ECO:0000250|UniProtKB:P23769}. FT MOD_RES 192 192 Phosphoserine. FT {ECO:0000250|UniProtKB:P23769}. FT CROSSLNK 389 389 Glycyl lysine isopeptide (Lys-Gly) FT (interchain with G-Cter in SUMO2). FT {ECO:0000250|UniProtKB:P23769}. SQ SEQUENCE 480 AA; 50468 MW; 7E0DCE9B53F49C8A CRC64; MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHSPWTVSP FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASSSAGG SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLATMGTQP ATHHPIPTYP SYVPAAAHDY GSSLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SSKSKKSKKG AECFEELSKC MQEKSPPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG //