ID GAT2_MOUSE STANDARD; PRT; 480 AA. AC O09100; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Endothelial transcription factor GATA-2. GN GATA2. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Liver; RA Suwabe N., Minegishi N., Yamamoto M.; RL Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=98123142; PubMed=9452491; RA Minegishi N., Ohta J., Suwabe N., Nakauchi H., Ishihara H., RA Hayashi N., Yamamoto M.; RT "Alternative promoters regulate transcription of the mouse GATA-2 RT gene."; RL J. Biol. Chem. 273:3625-3634(1998). CC -!- FUNCTION: TRANSCRIPTIONAL ACTIVATOR WHICH REGULATES ENDOTHELIN-1 CC GENE EXPRESSION IN ENDOTHELIAL CELLS. BINDS TO THE CONSENSUS CC SEQUENCE 5'-AGATAG-3'. CC -!- SUBCELLULAR LOCATION: Nuclear. CC -!- SIMILARITY: CONTAINS 2 GATA-TYPE ZINC FINGERS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB000096; BAA19053.1; -. DR HSSP; P17679; 1GNF. DR TRANSFAC; T01302; -. DR MGD; MGI:95662; Gata2. DR InterPro; IPR000679; ZnF_GATA. DR InterPro; IPR001164; Znf_GCS. DR Pfam; PF00320; GATA; 2. DR PRINTS; PR00619; GATAZNFINGER. DR SMART; SM00401; ZnF_GATA; 2. DR PROSITE; PS00344; GATA_ZN_FINGER_1; 2. DR PROSITE; PS50114; GATA_ZN_FINGER_2; 2. KW Transcription regulation; Activator; DNA-binding; Zinc-finger; KW Nuclear protein. FT ZN_FING 295 319 GATA-TYPE 1. FT ZN_FING 349 373 GATA-TYPE 2. SQ SEQUENCE 480 AA; 50450 MW; 458694EC3FA17035 CRC64; MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHSPWTVSP FSKTPLHPSA AGAPGGPLSV YPGSAGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASSSAGG SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLATMGTQP ATHHPIPTYP SYVPAAAHDY GSSLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SSKSKKSKKG AECFEELSKC MQEKSPPFSA AALAGHMAPV GHLPPLSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG //