ID O08906_MOUSE Unreviewed; 1300 AA. AC O08906; DT 01-JUL-1997, integrated into UniProtKB/TrEMBL. DT 01-JUL-1997, sequence version 1. DT 22-FEB-2023, entry version 83. DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493}; DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493}; DE Flags: Fragment; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAA20419.1}; RN [1] {ECO:0000313|EMBL:BAA20419.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Orleans reeler {ECO:0000313|EMBL:BAA20419.1}; RC TISSUE=Liver {ECO:0000313|EMBL:BAA20419.1}; RX PubMed=8817336; DOI=10.1093/hmg/5.7.989; RA Takahara T., Ohsumi T., Kuromitsu J., Shibata K., Sasaki N., Okazaki Y., RA Shibata H., Sato S., Yoshiki A., Kusakabe M., Muramatsu M., Ueki M., RA Okuda K., Hayashizaki Y.; RT "Dysfunction of the Orleans reeler gene arising from exon skipping due to RT transposition of a full-length copy of an active L1 sequence into the RT skipped exon."; RL Hum. Mol. Genet. 5:989-993(1996). RN [2] {ECO:0000313|EMBL:BAA20419.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Orleans reeler {ECO:0000313|EMBL:BAA20419.1}; RC TISSUE=Liver {ECO:0000313|EMBL:BAA20419.1}; RA Hayashizaki Y.; RT "Mouse L1 repetitive element, complete sequence."; RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D84391; BAA20419.1; -; Genomic_DNA. DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR CDD; cd09076; L1-EN; 1. DR CDD; cd01650; RT_nLTR_like; 1. DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1. DR InterPro; IPR043502; DNA/RNA_pol_sf. DR InterPro; IPR013544; DUF1725. DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf. DR InterPro; IPR005135; Endo/exonuclease/phosphatase. DR InterPro; IPR000477; RT_dom. DR PANTHER; PTHR19446:SF435; LINE-1 RETROTRANSPOSABLE ELEMENT ORF2 PROTEIN; 1. DR PANTHER; PTHR19446; REVERSE TRANSCRIPTASES; 1. DR Pfam; PF08333; DUF1725; 1. DR Pfam; PF03372; Exo_endo_phos; 1. DR Pfam; PF00078; RVT_1; 1. DR SUPFAM; SSF56672; DNA/RNA polymerases; 1. DR SUPFAM; SSF56219; DNase I-like; 1. DR PROSITE; PS50878; RT_POL; 1. PE 4: Predicted; KW Nucleotidyltransferase {ECO:0000313|EMBL:BAA20419.1}; KW RNA-directed DNA polymerase {ECO:0000313|EMBL:BAA20419.1}; KW Transferase {ECO:0000313|EMBL:BAA20419.1}. FT DOMAIN 524..799 FT /note="Reverse transcriptase" FT /evidence="ECO:0000259|PROSITE:PS50878" FT REGION 1..24 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..20 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:BAA20419.1" SQ SEQUENCE 1300 AA; 152069 MW; 3DD8D8996F637DE0 CRC64; KKQEGNPSTN LKEDSHKNRM PPLTTKITGS NNYFSLISLN INGLNSPIKR HRLTNWLHKQ DPTFCCLQET HLREKDRHYL RMKGWKTIFQ ANGMKKQAGV AILISDKIDF QPKVIKKDKE GHFILIKGKI LQEELSILNI YAPNKRAATF TKETLVKLKA HIAPHTIIVG DFNTPLSPMD RSWKQKLNRD TLKLTEVMKQ MDLTDIYRTF FPKTKGYTFF SAPHGTFSKI DHIIGHKSGL NRFKNIEIVP CILSDHHALR LIFNNKINNR KPTFTWKLNN TLLNDTLVKE GIKKEIKDFL EFNENEATTY PNLWDTMKAF LRGKLIAMSA FKKKRERAHT SSLTTHLKAL EKKEANSPKR SRRQEIIKLR GEINQVETRR TIQRINQTRS WFFEKINKID KPLARLTKGH RDKILINKIR NEKGDITTDP EEIQNTIRSF YKRLYSTKLE NLDEMDKFLD RYQVPKLNQD QVDLLNSPIS PKEIEAVINS LPAKKSPGPD GFSAEFYQTF KEDLTPVLHK LFHKIEVEGI LPNSFYEATI TLIPKPQKDP TKIENFRPIS LMNIDAKILN KILANRIQEH IKAIIHPDQV GFIPGMQGWF NIRKSINVIH YINKLKDKNH MIISLDAEKA FDKIQHPFMI KVLERSGIQG QYLNMIKAIY SKPVANIKVN GEKLEAIPLK SGTRQGCPLS PYLFNIVLEV LARAIRQQKE IKGIQIGKEE VKISLFADDM IVYISDPKNS NRELLNLINS FGEVAGYKIN SNKSMAFLYT KNKQAEKEIR ETTPFSIATN NIKYLGVTLT KEVKDLYDKN FKSLKKEIKE DLRRWKDLPC SWIGRTNIVK MAILPKAIYR FNAIPIKIPT QFFNELEGAI CKFIWNNKKP RIAKTLLKDK RTSGGITMPD LKLYYRAIVI KTAWYWYRDR QVDQWNRIED PEMNPHTYGH LIFDKGAKTI QWKKDSIFNN WCWHNWLLSC RRMRIDPYLS PCTKVKSKWI KELHIKPETL KLIEEKVGKS LEDMGTGEKF LNRTAMACAV RSRIDKWDLM KLQSFCKAKD TVYKTKRPPT DWERIFTYPK SDRGLISNIY KELKKVDLRK SNNPLKKWGS ELNKEFSPEE YRMAEKHLKK CSTSLIIREM QIKTTLRFHL TPVRMAKIKN SGDSRCWRGC GERGTLLHCW WNCRLVQPLW KSVWRFLRKL DIVLPEDPAI PLLGIYPEEA PTGKKDTCST MFIAALFIIA RNWKEPRCPS TEEWIQKMWY IYTMEYYSAI KKNEFMKFLA KWMDLESIIL SEVTQSQRNS HNMYSLISGY //