ID O08906_MOUSE Unreviewed; 1300 AA. AC O08906; DT 01-JUL-1997, integrated into UniProtKB/TrEMBL. DT 01-JUL-1997, sequence version 1. DT 05-OCT-2010, entry version 48. DE SubName: Full=Reverse transcriptase; DE Flags: Fragment; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Orleans reeler; TISSUE=Liver; RX MEDLINE=96414308; PubMed=8817336; DOI=10.1093/hmg/5.7.989; RA Takahara T., Ohsumi T., Kuromitsu J., Shibata K., Sasaki N., RA Okazaki Y., Shibata H., Sato S., Yoshiki A., Kusakabe M., RA Muramatsu M., Ueki M., Okuda K., Hayashizaki Y.; RT "Dysfunction of the Orleans reeler gene arising from exon skipping due RT to transposition of a full-length copy of an active L1 sequence into RT the skipped exon."; RL Hum. Mol. Genet. 5:989-993(1996). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Orleans reeler; TISSUE=Liver; RA Hayashizaki Y.; RT "Mouse L1 repetitive element, complete sequence."; RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Contains 1 reverse transcriptase domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D84391; BAA20419.1; -; Genomic_DNA. DR IPI; IPI00113988; -. DR ProteinModelPortal; O08906; -. DR eggNOG; roNOG04397; -. DR HOVERGEN; HBG006270; -. DR Genevestigator; O08906; -. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0006278; P:RNA-dependent DNA replication; IEA:InterPro. DR InterPro; IPR013544; DUF1725. DR InterPro; IPR005135; Endo/exonuclease/phosphatase. DR InterPro; IPR015706; Reverse_transcriptase. DR InterPro; IPR000477; RVT. DR PANTHER; PTHR19446; Rev_txptase; 1. DR Pfam; PF08333; DUF1725; 1. DR Pfam; PF03372; Exo_endo_phos; 1. DR Pfam; PF00078; RVT_1; 1. DR SUPFAM; SSF56219; Exo_endo_phos; 1. DR PROSITE; PS50878; RT_POL; 1. PE 4: Predicted; KW RNA-directed DNA polymerase. FT NON_TER 1 1 SQ SEQUENCE 1300 AA; 152069 MW; 3DD8D8996F637DE0 CRC64; KKQEGNPSTN LKEDSHKNRM PPLTTKITGS NNYFSLISLN INGLNSPIKR HRLTNWLHKQ DPTFCCLQET HLREKDRHYL RMKGWKTIFQ ANGMKKQAGV AILISDKIDF QPKVIKKDKE GHFILIKGKI LQEELSILNI YAPNKRAATF TKETLVKLKA HIAPHTIIVG DFNTPLSPMD RSWKQKLNRD TLKLTEVMKQ MDLTDIYRTF FPKTKGYTFF SAPHGTFSKI DHIIGHKSGL NRFKNIEIVP CILSDHHALR LIFNNKINNR KPTFTWKLNN TLLNDTLVKE GIKKEIKDFL EFNENEATTY PNLWDTMKAF LRGKLIAMSA FKKKRERAHT SSLTTHLKAL EKKEANSPKR SRRQEIIKLR GEINQVETRR TIQRINQTRS WFFEKINKID KPLARLTKGH RDKILINKIR NEKGDITTDP EEIQNTIRSF YKRLYSTKLE NLDEMDKFLD RYQVPKLNQD QVDLLNSPIS PKEIEAVINS LPAKKSPGPD GFSAEFYQTF KEDLTPVLHK LFHKIEVEGI LPNSFYEATI TLIPKPQKDP TKIENFRPIS LMNIDAKILN KILANRIQEH IKAIIHPDQV GFIPGMQGWF NIRKSINVIH YINKLKDKNH MIISLDAEKA FDKIQHPFMI KVLERSGIQG QYLNMIKAIY SKPVANIKVN GEKLEAIPLK SGTRQGCPLS PYLFNIVLEV LARAIRQQKE IKGIQIGKEE VKISLFADDM IVYISDPKNS NRELLNLINS FGEVAGYKIN SNKSMAFLYT KNKQAEKEIR ETTPFSIATN NIKYLGVTLT KEVKDLYDKN FKSLKKEIKE DLRRWKDLPC SWIGRTNIVK MAILPKAIYR FNAIPIKIPT QFFNELEGAI CKFIWNNKKP RIAKTLLKDK RTSGGITMPD LKLYYRAIVI KTAWYWYRDR QVDQWNRIED PEMNPHTYGH LIFDKGAKTI QWKKDSIFNN WCWHNWLLSC RRMRIDPYLS PCTKVKSKWI KELHIKPETL KLIEEKVGKS LEDMGTGEKF LNRTAMACAV RSRIDKWDLM KLQSFCKAKD TVYKTKRPPT DWERIFTYPK SDRGLISNIY KELKKVDLRK SNNPLKKWGS ELNKEFSPEE YRMAEKHLKK CSTSLIIREM QIKTTLRFHL TPVRMAKIKN SGDSRCWRGC GERGTLLHCW WNCRLVQPLW KSVWRFLRKL DIVLPEDPAI PLLGIYPEEA PTGKKDTCST MFIAALFIIA RNWKEPRCPS TEEWIQKMWY IYTMEYYSAI KKNEFMKFLA KWMDLESIIL SEVTQSQRNS HNMYSLISGY //