ID COX1_TINMA Reviewed; 337 AA. AC O03554; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1997, sequence version 1. DT 04-FEB-2015, entry version 82. DE RecName: Full=Cytochrome c oxidase subunit 1; DE EC=1.9.3.1; DE AltName: Full=Cytochrome c oxidase polypeptide I; DE Flags: Fragment; GN Name=MT-CO1; Synonyms=COI, COXI, MTCO1; OS Tinamus major (Great tinamou) (Tetrao major). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Palaeognathae; Tinamiformes; Tinamidae; Tinamus. OX NCBI_TaxID=30468; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Lee K., Feinstein J., Cracraft J.; RT "Phylogenetic relationships of the ratite birds: resolving conflicts RT between molecular and morphological data sets."; RL (In) Mindell D.P. (eds.); RL Avian molecular evolution and systematics, pp.1-1, Academic Press, New RL York (1997). CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory CC chain that catalyzes the reduction of oxygen to water. Subunits 1- CC 3 form the functional core of the enzyme complex. CO I is the CC catalytic subunit of the enzyme. Electrons originating in CC cytochrome c are transferred via the copper A center of subunit 2 CC and heme A of subunit 1 to the bimetallic center formed by heme A3 CC and copper B. CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4 CC ferricytochrome c + 2 H(2)O. CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass CC membrane protein. CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U76063; AAB61331.1; -; Genomic_DNA. DR ProteinModelPortal; O03554; -. DR SMR; O03554; 3-337. DR HOVERGEN; HBG003841; -. DR UniPathway; UPA00705; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0045277; C:respiratory chain complex IV; ISS:UniProtKB. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0005506; F:iron ion binding; IEA:InterPro. DR GO; GO:0009060; P:aerobic respiration; IEA:InterPro. DR GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway. DR Gene3D; 1.20.210.10; -; 1. DR InterPro; IPR000883; COX1. DR InterPro; IPR023615; Cyt_c_Oxase_su1_BS. DR InterPro; IPR023616; Cyt_c_Oxase_su1_dom. DR PANTHER; PTHR10422; PTHR10422; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR SUPFAM; SSF81442; SSF81442; 1. DR PROSITE; PS50855; COX1; 1. DR PROSITE; PS00077; COX1_CUB; 1. PE 3: Inferred from homology; KW Copper; Electron transport; Heme; Iron; Membrane; Metal-binding; KW Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; KW Respiratory chain; Transmembrane; Transmembrane helix; Transport. FT CHAIN 1 >337 Cytochrome c oxidase subunit 1. FT /FTId=PRO_0000183426. FT TRANSMEM 18 38 Helical. {ECO:0000255}. FT TRANSMEM 64 84 Helical. {ECO:0000255}. FT TRANSMEM 103 123 Helical. {ECO:0000255}. FT TRANSMEM 146 166 Helical. {ECO:0000255}. FT TRANSMEM 184 204 Helical. {ECO:0000255}. FT TRANSMEM 235 255 Helical. {ECO:0000255}. FT TRANSMEM 269 289 Helical. {ECO:0000255}. FT TRANSMEM 311 331 Helical. {ECO:0000255}. FT METAL 62 62 Iron (heme A axial ligand). FT {ECO:0000305}. FT METAL 241 241 Copper B. {ECO:0000305}. FT METAL 245 245 Copper B. {ECO:0000305}. FT METAL 291 291 Copper B. {ECO:0000305}. FT METAL 292 292 Copper B. {ECO:0000305}. FT CROSSLNK 241 245 1'-histidyl-3'-tyrosine (His-Tyr). FT {ECO:0000250}. FT NON_TER 337 337 SQ SEQUENCE 337 AA; 36806 MW; 637DBE38B678F319 CRC64; MTFITRWLFS TNHKDIGTLY LIFGAWAGMV GTALSLLIRA ELGQPGTLLG DDQIYNVVVT AHAFVMIFFM VMPVMIGGFG NWLVPLMIGA PDMAFPRMNN MSFWLLPPSF LLLLASSTVE TGVGTGWTVY PPLASNLAHA GASVDLAIFS LHLAGVSSIL GAINFITTAI NMKPPALTQY QTPLFVWSVL ITAILLLLSL PVLAAGITML LTDRNLNTTF FDPAGGGDPI LYQHLFWFFG HPEVYILILP GFGIISHVVA YYAGKKEPFG YMGMVWAMLS IGFLGFIVWA HHMFTVGMDV DTRAYFTSAT MIIAIPTGIK VFSWLATLHG GTIKWDP //