ID PTPR2_MACNE STANDARD; PRT; 1013 AA. AC O02695; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 07-FEB-2006 (Rel. 49, Last annotation update) DE Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) DE (R-PTP-N2) (M1851). GN Name=PTPRN2; OS Macaca nemestrina (Pig-tailed macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; OC Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9545; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Pancreatic islets; RX MEDLINE=97254813; PubMed=9100223; RA Lagasse J., Jelinek L., Sexson S., Lofton-Day C.E., Breininger J., RA Sheppard P., Kindsvogel W., Hagopian W.A.; RT "An islet-cell protein tyrosine phosphatase is a likely precursor to RT the 37-kDa autoantigen in type 1 diabetes: human and macaque RT sequences, tissue distribution, unique and shared epitopes, and RT predictive autoantibodies."; RL Mol. Med. 3:163-173(1997). CC -!- FUNCTION: Implicated in development of nervous system and CC pancreatic endocrine cells. CC -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein CC tyrosine + phosphate. CC -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane CC protein (Probable). CC -!- TISSUE SPECIFICITY: Brain, prostate, pancreatic islets. Lower CC expression in spinal cord, thyroid, adrenal medulla and CC gastrointestinal tract. CC -!- PTM: Appears to undergo multiple proteolytic cleavage at CC consecutive basic residues (By similarity). CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. CC Receptor class 8 subfamily. CC -!- SIMILARITY: Contains 1 tyrosine-protein phosphatase domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U91574; AAC51186.1; -; mRNA. DR HSSP; P18052; 1YFO. DR LinkHub; O02695; -. DR InterPro; IPR000387; TYR_phosphatase. DR InterPro; IPR000242; Tyr_PP. DR Pfam; PF00102; Y_phosphatase; 1. DR PRINTS; PR00700; PRTYPHPHTASE. DR SMART; SM00194; PTPc; 1. DR SMART; SM00404; PTPc_motif; 1. DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1. DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1. DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1. KW Glycoprotein; Hydrolase; Membrane; Protein phosphatase; Receptor; KW Signal; Transmembrane. FT SIGNAL 1 19 Potential. FT CHAIN 20 1013 Receptor-type tyrosine-protein FT phosphatase N2. FT /FTId=PRO_0000025455. FT TOPO_DOM 20 613 Extracellular (Potential). FT TRANSMEM 614 634 Potential. FT TOPO_DOM 635 1013 Cytoplasmic (Potential). FT DOMAIN 743 1003 Tyrosine-protein phosphatase. FT ACT_SITE 943 943 Phosphocysteine intermediate (Potential). FT SITE 425 426 Cleavage (By similarity). FT CARBOHYD 562 562 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 1013 AA; 111191 MW; 4808D43937A2EF59 CRC64; MALPLLLLLL LLLPPRVLPA APSSVPHGRQ LPGRLGCLLE EGLCGASEAC VNDGVFGRCQ KVPAMDFYRY EVSPVALQRL RVALQKLSGT GFTWQDDYTQ YVMDQELADL PKTYLRHPEA SGPARPSKHS IGSERRYSQE GGAALAKAFR RHLPFLEALS QAPASDALAR TRMAQDRPRA EGDDRFSKSI LTYVAHTSVL TYPPGPQAQL PEDLLPRTLS QLQPDELSPK VDSSVERHHL MAALSAYAAQ RPPAPPGKGS LEPQYLLRAP SRMPRPLLSP AVPQKWPSPL GDPEDPPSTG EGARIHTLLK DLQRQPAEAR GLSDLELDSM AELMAGLMQG MDHRGALGGP GKAALGESGE QADGPKAALR GESFPDDGVQ DDDDRLYQEV HRLSATLGGL LQDHGSRLSP GALPFAKPLK MERKKSERPE ASLSSEEETA GVENVKSQTY SKDLLGQQPH SEPGAGAFGE LQNQMPGPSE EEQSLPAGAQ EALGDGLQLE VKPSEEEARG YIVTDRDPLR PEEGRQLVED VARLLQMPSS TFADVEVLGP AVTFKVGANV QNVTTADVEK ATVDNKDKLE ETSGLKILQT GVGSKSKLKF LPPQAEQEDS TKFIALTLVS LACILGVLLA SGLIYCLRHS SQHRLKEKLS GLGRDPGADA TAAYQELCRQ RMATRPPDRP EGPHTSRISS VSSQFSDGPM PSPSARSSAS SWSEEPVQSN MDISTGHMIL SYMEDHLKNK NRLEKEWEAL CAYQAEPNSS LVAQKEENVP KNRSLAVLTY DHSRVLLKAE NSHSHSDYIN ASPIMDHDPR NPAYIATQGP LPATVADFWQ MVWESGCVVI VMLTPLTENG VRQCYHYWPD EGSNLYHIYE VNLVSEHIWC EDFLVRSFYL KNLQTNETRT VTQFHFLSWY DRGVPSSSRS LLDFRRKVNK CYRGRSCPII VHCSDGAGRS GTYVLIDMVL NKMAKGAKEI DIAATLEHLR DQRPGMVQTK EQFEFALTAV AEEVNAILKA LPQ //