ID PTPX_MACNE STANDARD; PRT; 1013 AA. AC O02695; DT 01-NOV-1997 (REL. 35, CREATED) DT 01-NOV-1997 (REL. 35, LAST SEQUENCE UPDATE) DT 01-NOV-1997 (REL. 35, LAST ANNOTATION UPDATE) DE PROTEIN-TYROSINE PHOSPHATASE X PRECURSOR (EC 3.1.3.48) (R-PTP-X) DE (M1851). GN PTPRN2. OS MACACA NEMESTRINA (PIG-TAILED MACAQUE). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=PANCREAS; RA LAGASSE J.M., JELINEK L., SEXSON S., LOFTON-DAY K., BREININGER J., RA SHEPPARD P., KINDSVOGEL W., HAGOPIAN W.A.; RL MOL. MED. 3:163-173(1997). CC -!- FUNCTION: IMPLICATED IN DEVELOPMENT OF NERVOUS SYSTEM AND CC PANCREATIC ENDOCRINE CELLS. CC -!- CATALYTIC ACTIVITY: PROTEIN TYROSINE PHOSPHATE + H(2)O = CC PROTEIN TYROSINE + ORTHOPHOSPHATE. CC -!- SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN (PROBABLE). CC -!- TISSUE SPECIFICITY: PANCREAS. CC -!- DISEASE: AUTOANTIGEN IN INSULIN-DEPENDENT DIABETES MELLITUS. CC -!- SIMILARITY: CONTAINS 1 PROTEIN-TYROSINE PHOSPHATASE DOMAIN. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U91574; G1916942; -. DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1. DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1. DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1. KW HYDROLASE; RECEPTOR; GLYCOPROTEIN; SIGNAL; TRANSMEMBRANE. FT SIGNAL 1 20 POTENTIAL. FT CHAIN 21 1013 PROTEIN-TYROSINE PHOSPHATASE X. FT DOMAIN 22 613 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 614 634 POTENTIAL. FT DOMAIN 635 1013 CYTOPLASMIC (POTENTIAL). FT ACT_SITE 943 943 POTENTIAL. FT CARBOHYD 562 562 POTENTIAL. SQ SEQUENCE 1013 AA; 111190 MW; 9EC7D263 CRC32; MALPLLLLLL LLLPPRVLPA APSSVPHGRQ LPGRLGCLLE EGLCGASEAC VNDGVFGRCQ KVPAMDFYRY EVSPVALQRL RVALQKLSGT GFTWQDDYTQ YVMDQELADL PKTYLRHPEA SGPARPSKHS IGSERRYSQE GGAALAKAFR RHLPFLEALS QAPASDALAR TRMAQDRPRA EGDDRFSKSI LTYVAHTSVL TYPPGPQAQL PEDLLPRTLS QLQPDELSPK VDSSVERHHL MAALSAYAAQ RPPAPPGKGS LEPQYLLRAP SRMPRPLLSP AVPQKWPSPL GDPEDPPSTG EGARIHTLLK DLQRQPAEAR GLSDLELDSM AELMAGLMQG MDHRGALGGP GKAALGESGE QADGPKAALR GESFPDDGVQ DDDDRLYQEV HRLSATLGGL LQDHGSRLSP GALPFAKPLK MERKKSERPE ASLSSEEETA GVENVKSQTY SKDLLGQQPH SEPGAGAFGE LQNQMPGPSE EEQSLPAGAQ EALGDGLQLE VKPSEEEARG YIVTDRDPLR PEEGRQLVED VARLLQMPSS TFADVEVLGP AVTFKVGANV QNVTTADVEK ATVDNKDKLE ETSGLKILQT GVGSKSKLKF LPPQAEQEDS TKFIALTLVS LACILGVLLA SGLIYCLRHS SQHRLKEKLS GLGRDPGADA TAAYQELCRQ RMATRPPDRP EGPHTSRISS VSSQFSDGPM PSPSARSSAS SWSEEPVQSN MDISTGHMIL SYMEDHLKNK NRLEKEWEAL CAYQAEPNSS LVAQKEENVP KNRSLAVLTY DHSRVLLKAE NSHSHSDYIN ASPIMDHDPR NPAYIATQGP LPATVADFWQ MVWESGCVVI VMLTPLTENG VRQCYHYWPD EGSNLYHIYE VNLVSEHIWC EDFLVRSFYL KNLQTNETRT VTQFHFLSWY DRGVPSSSRS LLDFRRKVNK CYRGRSCPII VHCSDGAGRS GTYVLIDMVL NKMAKGAKEI DIAATLEHLR DQRPGMVQTK EQFEFALTAV AEEVNAILKA LPQ //