ID O01965_CAEEL Unreviewed; 494 AA. AC O01965; DT 01-JUL-1997, integrated into UniProtKB/TrEMBL. DT 01-DEC-2001, sequence version 3. DT 31-JAN-2018, entry version 122. DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|SAAS:SAAS00970528}; DE EC=2.3.2.27 {ECO:0000256|SAAS:SAAS00970528}; GN Name=ari-1 {ECO:0000313|EMBL:CCD61206.1, GN ECO:0000313|WormBase:C27A12.8}; GN ORFNames=C27A12.8 {ECO:0000313|WormBase:C27A12.8}, CELE_C27A12.8 GN {ECO:0000313|EMBL:CCD61206.1}; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis. OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD61206.1, ECO:0000313|Proteomes:UP000001940}; RN [1] {ECO:0000313|EMBL:CCD61206.1, ECO:0000313|Proteomes:UP000001940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD61206.1, RC ECO:0000313|Proteomes:UP000001940}; RX PubMed=9851916; DOI=https://doi.org/10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RA Sulson J.E., Waterston R.; RT "Genome sequence of the nematode C. elegans: a platform for RT investigating biology."; RL Science 282:2012-2018(1998). CC -!- CATALYTIC ACTIVITY: S-ubiquitinyl-[E2 ubiquitin-conjugating CC enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin- CC conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor CC protein]-L-lysine. {ECO:0000256|SAAS:SAAS00692260}. CC -!- SIMILARITY: Belongs to the RBR family. CC {ECO:0000256|SAAS:SAAS00692262}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX284601; CCD61206.1; -; Genomic_DNA. DR PIR; H87793; H87793. DR RefSeq; NP_491749.2; NM_059348.5. DR UniGene; Cel.7447; -. DR ProteinModelPortal; O01965; -. DR IntAct; O01965; 1. DR STRING; 6239.C27A12.8.2; -. DR EPD; O01965; -. DR PaxDb; O01965; -. DR PeptideAtlas; O01965; -. DR EnsemblMetazoa; C27A12.8.1; C27A12.8.1; WBGene00016158. DR EnsemblMetazoa; C27A12.8.2; C27A12.8.2; WBGene00016158. DR GeneID; 172284; -. DR KEGG; cel:CELE_C27A12.8; -. DR UCSC; C27A12.8.1; c. elegans. DR CTD; 32796; -. DR WormBase; C27A12.8; CE29680; WBGene00016158; ari-1. DR eggNOG; KOG1815; Eukaryota. DR eggNOG; ENOG410XP9Y; LUCA. DR GeneTree; ENSGT00890000139392; -. DR HOGENOM; HOG000216612; -. DR InParanoid; O01965; -. DR KO; K11968; -. DR OMA; LARYLHY; -. DR OrthoDB; EOG091G01SC; -. DR PhylomeDB; O01965; -. DR Reactome; R-CEL-1169408; ISG15 antiviral mechanism. DR Proteomes; UP000001940; Chromosome I. DR Bgee; WBGene00016158; -. DR GO; GO:0005737; C:cytoplasm; IDA:WormBase. DR GO; GO:0005634; C:nucleus; IDA:WormBase. DR GO; GO:0000151; C:ubiquitin ligase complex; IBA:GO_Central. DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IBA:GO_Central. DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central. DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central. DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central. DR GO; GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:GO_Central. DR Gene3D; 3.30.40.10; -; 1. DR InterPro; IPR031127; E3_UB_ligase_RBR. DR InterPro; IPR002867; IBR_dom. DR InterPro; IPR013083; Znf_RING/FYVE/PHD. DR PANTHER; PTHR11685; PTHR11685; 1. DR Pfam; PF01485; IBR; 2. DR SMART; SM00647; IBR; 2. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000001940}; KW Ligase {ECO:0000313|EMBL:CCD61206.1}; KW Metal-binding {ECO:0000256|SAAS:SAAS00099750}; KW Proteomics identification {ECO:0000213|EPD:O01965, KW ECO:0000213|PeptideAtlas:O01965}; KW Reference proteome {ECO:0000313|Proteomes:UP000001940}; KW Repeat {ECO:0000256|SAAS:SAAS00692254}; KW Transferase {ECO:0000256|SAAS:SAAS00692250}; KW Zinc {ECO:0000256|SAAS:SAAS00099744}; KW Zinc-finger {ECO:0000256|SAAS:SAAS00468068}. FT DOMAIN 194 255 IBR-type. {ECO:0000259|SMART:SM00647}. FT DOMAIN 263 327 IBR-type. {ECO:0000259|SMART:SM00647}. SQ SEQUENCE 494 AA; 57251 MW; 25BF128B84F805E3 CRC64; MSSDDEINMD DSDSSQGEID DGCMSDDDGI VLESREQNSS DYKDNGEPDN EVLNHDSLEA EMKKTITDVQ AVLQVKTGVC RILLHKYKWN KESLLERFYE HPDTTTFLID AHVIPRRQER LPAGDAECDI CCSLGELSGL SCNHRACTQC WKAYLTNKIA NNAQSEIECM APNCKLLIED EKVMFYITDP TVIATYRKLI VASYVETNRL LKWCPGIDCG KAVRVSHWEP RLVVCSCGSR FCFSCGHDWH EPVNCRLLKL WLKKCNDDSE TSNWINANTK ECPKCMITIE KDGGCNHMTC KNTACRFEFC WMCLGPWEPH GSSWYSCNRF DDSAAKNARD AQEVSRANLQ RYLFYYNRYM GHQQSLRLEG KLYATVKSKM EQMQTLSMSW IEVQFLRKAV DVLSECRRTL MFTYAFAFYL KRDNNAIIFE SNQKDLEMET EQLSGFLERD LDNENLVTLK QKVQDKYRYV EHRRKVLLDH CSEGADQELW VFNE //