ID O01467_CAEEL Unreviewed; 515 AA. AC O01467; DT 01-JUL-1997, integrated into UniProtKB/TrEMBL. DT 01-JUN-2001, sequence version 2. DT 02-OCT-2024, entry version 143. DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759}; DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759}; GN ORFNames=C04E6.5 {ECO:0000313|EMBL:CCD62893.1, GN ECO:0000313|WormBase:C04E6.5}, CELE_C04E6.5 GN {ECO:0000313|EMBL:CCD62893.1}; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; OC Caenorhabditis. OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD62893.1, ECO:0000313|Proteomes:UP000001940}; RN [1] {ECO:0000313|EMBL:CCD62893.1, ECO:0000313|Proteomes:UP000001940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD62893.1, RC ECO:0000313|Proteomes:UP000001940}; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RA Sulson J.E., Waterston R.; RT "Genome sequence of the nematode C. elegans: a platform for investigating RT biology."; RL Science 282:2012-2018(1998). CC -!- CATALYTIC ACTIVITY: CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- CC residue protein attached to proteins as an intracellular targeting CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX284605; CCD62893.1; -; Genomic_DNA. DR RefSeq; NP_504537.1; NM_072136.3. DR AlphaFoldDB; O01467; -. DR STRING; 6239.C04E6.5.1; -. DR PaxDb; 6239-C04E6.5; -. DR EnsemblMetazoa; C04E6.5.1; C04E6.5.1; WBGene00015422. DR GeneID; 178977; -. DR KEGG; cel:CELE_C04E6.5; -. DR UCSC; C04E6.5; c. elegans. DR AGR; WB:WBGene00015422; -. DR CTD; 178977; -. DR WormBase; C04E6.5; CE27053; WBGene00015422; -. DR eggNOG; KOG1864; Eukaryota. DR GeneTree; ENSGT00940000172369; -. DR HOGENOM; CLU_529182_0_0_1; -. DR InParanoid; O01467; -. DR OMA; FERECYV; -. DR OrthoDB; 3686320at2759; -. DR PhylomeDB; O01467; -. DR Reactome; R-CEL-5689880; Ub-specific processing proteases. DR Proteomes; UP000001940; Chromosome V. DR Bgee; WBGene00015422; Expressed in material anatomical entity and 2 other cell types or tissues. DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro. DR GO; GO:0016579; P:protein deubiquitination; IEA:InterPro. DR CDD; cd02673; Peptidase_C19Q; 1. DR Gene3D; 3.90.70.10; Cysteine proteinases; 1. DR InterPro; IPR038765; Papain-like_cys_pep_sf. DR InterPro; IPR001394; Peptidase_C19_UCH. DR InterPro; IPR050185; Ub_carboxyl-term_hydrolase. DR InterPro; IPR028889; USP_dom. DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1. DR PANTHER; PTHR21646:SF112; USP DOMAIN-CONTAINING PROTEIN-RELATED; 1. DR Pfam; PF00443; UCH; 1. DR SUPFAM; SSF54001; Cysteine proteinases; 1. DR PROSITE; PS50235; USP_3; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Reference proteome {ECO:0000313|Proteomes:UP000001940}. FT DOMAIN 145..515 FT /note="USP" FT /evidence="ECO:0000259|PROSITE:PS50235" FT REGION 81..136 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 1..67 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 515 AA; 59148 MW; C67CE581BC6BC846 CRC64; MRDFVTDINN ATEELLKLNL ESAVTQDTFN LLVVYFNDLL VGKEKEIAEL KEEIEELKKP LEENKMAPLL EIVRSEVFPE QLEHPSKNAT NTGSRKRAHP KLFEASEPKV KSSNVSTDVI DGKKHNNRKT NSSRSFSKVN SSVTRKLVNT GNSCFLNSTM QALSSCHSFA LRCEQLYCLV RKNIDYFDNE ASHSEVLCRK YRVLIDFLKI MAALTKRSNS SKTQPEIIEA NLQTFRELIG MIRNDFANKN QQDAHEFLLM LFEAIDDVAE YKADNEGDDV KEAKQLNPIE AFKFNVETCY VCKGCSKEEV RVDVRNDLAV HMRDNLSVQE LLSSSFSTWT PIEKKCSSCN HQHAILSERI TRFPECLVIN LERYQLEGPQ FSTKKINCSL EPSFELDISS LQKFPEIEKN GLEQSEKQQD SQYGQLLDRM KSCEIIKCCE TKNIIMEEKH DKYSLVAAIC HLGETPTNGH YIAYTREDTE NSWLYCSDDL IRPATRSEIS LSIRTSGYIL FYEYE //