ID M9ZZJ1_ZIPCA Unreviewed; 459 AA. AC M9ZZJ1; DT 26-JUN-2013, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 1. DT 05-DEC-2018, entry version 27. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4 {ECO:0000256|RuleBase:RU003297}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU003297}; GN Name=ND4 {ECO:0000313|EMBL:AGK37996.1}; OS Ziphius cavirostris (Cuvier's beaked whale) (Goose-beaked whale). OG Mitochondrion {ECO:0000313|EMBL:AGK37996.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Cetacea; OC Odontoceti; Ziphiidae; Ziphius. OX NCBI_TaxID=9760 {ECO:0000313|EMBL:AGK37996.1}; RN [1] {ECO:0000313|EMBL:AGK37996.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=SWFSC ID z0079887 {ECO:0000313|EMBL:AGK37996.1}; RA Morin P.A., Duchene S., Lee N., Durban J., Claridge D.; RT "Preliminary analysis of mitochondrial genome phylogeography of RT Blainville's, Cuvier's and Gervais' beaked whales."; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone. {ECO:0000256|RuleBase:RU003297}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, CC ChEBI:CHEBI:57945, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566; CC EC=7.1.1.2; Evidence={ECO:0000256|RuleBase:RU003297}; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane CC {ECO:0000256|RuleBase:RU003297}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU003297}. CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. CC {ECO:0000256|RuleBase:RU003297, ECO:0000256|SAAS:SAAS00707377}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KC776699; AGK37996.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro. DR InterPro; IPR000260; NADH4_N. DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4. DR InterPro; IPR003918; NADH_UbQ_OxRdtase. DR InterPro; IPR001750; ND/Mrp_mem. DR PANTHER; PTHR43507; PTHR43507; 1. DR Pfam; PF01059; Oxidored_q5_N; 1. DR Pfam; PF00361; Proton_antipo_M; 1. DR PRINTS; PR01437; NUOXDRDTASE4. DR TIGRFAMs; TIGR01972; NDH_I_M; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU003297}; KW Membrane {ECO:0000256|RuleBase:RU003297, KW ECO:0000256|SAAS:SAAS00707373}; KW Mitochondrion {ECO:0000256|RuleBase:RU003297, KW ECO:0000313|EMBL:AGK37996.1}; KW NAD {ECO:0000256|RuleBase:RU003297, ECO:0000256|SAAS:SAAS00707374}; KW Respiratory chain {ECO:0000256|RuleBase:RU003297}; KW Transmembrane {ECO:0000256|RuleBase:RU003297, KW ECO:0000256|SAAS:SAAS00707385}; KW Transmembrane helix {ECO:0000256|RuleBase:RU003297, KW ECO:0000256|SAAS:SAAS00707361}; KW Transport {ECO:0000256|RuleBase:RU003297}; KW Ubiquinone {ECO:0000256|RuleBase:RU003297, KW ECO:0000256|SAAS:SAAS00699082}. FT TRANSMEM 21 42 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 54 73 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 94 110 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 116 133 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 145 167 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 194 216 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 223 244 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 256 277 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 284 303 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 309 329 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 350 369 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 389 414 Helical. {ECO:0000256|RuleBase:RU003297}. FT DOMAIN 77 109 Oxidored_q5_N. {ECO:0000259|Pfam: FT PF01059}. FT DOMAIN 112 403 Proton_antipo_M. {ECO:0000259|Pfam: FT PF00361}. SQ SEQUENCE 459 AA; 51517 MW; 5F6D49C3BAF24AD8 CRC64; MLKFIIPXXX XXXXXXXXXX XXIXXXXXAH SLLISFTSLL LLNQFXDNSL NYSLTXXXXX XXXXXXXXXX XXXXXXLXAS QSHLLKEPLT RKKLYITMLI TLQALLIMTF TAMELILXYI MFEATXVPTL IIITRWGNQT ERLNAGLYFL FYTLVGSLPL LVALTYLQNT MGTLNFLLLQ HWAQPLSPSW SNTLMWLACM MAFLVKMPLY GLHLWLPKAH VEAPIAGSMV LAAVLLKLGG YGMLRITPLL NPLTEHMAYP FLMLSLWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIAA ILIQTPWSFM GATALMIAHG LTSSMLFCLA NSNYERIHSR TMILARGLQI FLPLMAAWWL LASMTNLALP PTINLIGELL VVMSAFSWSN LTIILMGTNI VITALYSLYM LIMTQRGKHT HHINNLTPSF TREHALMALH IMPLLLLSLN PKIILGPLY //