ID M9TGV3_MYCTX Unreviewed; 269 AA. AC M9TGV3; DT 26-JUN-2013, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 1. DT 29-SEP-2021, entry version 76. DE RecName: Full=Enoyl-[acyl-carrier-protein] reductase [NADH] {ECO:0000256|ARBA:ARBA00017755, ECO:0000256|PIRNR:PIRNR000094}; DE EC=1.3.1.9 {ECO:0000256|PIRNR:PIRNR000094}; GN Name=inhA {ECO:0000313|EMBL:AGJ50654.1}; GN Synonyms=fabI {ECO:0000313|EMBL:QNF01511.1}; GN ORFNames=E5M05_03060 {ECO:0000313|EMBL:TGE07195.1}, E5M52_03035 GN {ECO:0000313|EMBL:TGD81125.1}, ERS007663_02660 GN {ECO:0000313|EMBL:CNV22734.1}, ERS007670_02839 GN {ECO:0000313|EMBL:CNV27465.1}, ERS007679_02961 GN {ECO:0000313|EMBL:COW03350.1}, ERS007681_02786 GN {ECO:0000313|EMBL:CFE41166.1}, ERS007683_00668 GN {ECO:0000313|EMBL:COU66734.1}, ERS007688_00531 GN {ECO:0000313|EMBL:CFE46976.1}, ERS007741_01725 GN {ECO:0000313|EMBL:COW17773.1}, ERS013440_02685 GN {ECO:0000313|EMBL:CNW87781.1}, ERS024276_00561 GN {ECO:0000313|EMBL:CKN85930.1}, ERS027659_00857 GN {ECO:0000313|EMBL:CKR17592.1}, ERS027661_03047 GN {ECO:0000313|EMBL:CKS41591.1}, FPJ30_08155 GN {ECO:0000313|EMBL:QOP36281.1}, FPJ31_08165 GN {ECO:0000313|EMBL:QOP32166.1}, FPJ32_08155 GN {ECO:0000313|EMBL:QOP28047.1}, FPJ33_08165 GN {ECO:0000313|EMBL:QOP23950.1}, FPJ34_08160 GN {ECO:0000313|EMBL:QOP19830.1}, FPJ35_08175 GN {ECO:0000313|EMBL:QOP15733.1}, FPJ36_08150 GN {ECO:0000313|EMBL:QOP11602.1}, FPJ37_08170 GN {ECO:0000313|EMBL:QOP07496.1}, FPJ38_08225 GN {ECO:0000313|EMBL:QOP03381.1}, FPJ39_08160 GN {ECO:0000313|EMBL:QOO99250.1}, FPJ40_08155 GN {ECO:0000313|EMBL:QOO95136.1}, FPJ41_08155 GN {ECO:0000313|EMBL:QOO91021.1}, FPJ43_08170 GN {ECO:0000313|EMBL:QOO82795.1}, FPJ44_08140 GN {ECO:0000313|EMBL:QOO78666.1}, FPJ45_08160 GN {ECO:0000313|EMBL:QOO74551.1}, FPJ46_08150 GN {ECO:0000313|EMBL:QOO70440.1}, FPJ48_08145 GN {ECO:0000313|EMBL:QOO62215.1}, FPJ49_08170 GN {ECO:0000313|EMBL:QOK38226.1}, FPJ50_08150 GN {ECO:0000313|EMBL:QOO58108.1}, FPJ51_08145 GN {ECO:0000313|EMBL:QOO53999.1}, FPJ52_08165 GN {ECO:0000313|EMBL:QOK42344.1}, FPJ53_08160 GN {ECO:0000313|EMBL:QOO49883.1}, FPJ54_08170 GN {ECO:0000313|EMBL:QOO45768.1}, FPJ55_08170 GN {ECO:0000313|EMBL:QOO41640.1}, FPJ56_08150 GN {ECO:0000313|EMBL:QOO37533.1}, FPJ57_08145 GN {ECO:0000313|EMBL:QOO33428.1}, FPJ58_08170 GN {ECO:0000313|EMBL:QOO29317.1}, FPJ59_08155 GN {ECO:0000313|EMBL:QOO25195.1}, FPJ60_08175 GN {ECO:0000313|EMBL:QOO21074.1}, FPJ61_08160 GN {ECO:0000313|EMBL:QOO16963.1}, FPJ63_08145 GN {ECO:0000313|EMBL:QOO08653.1}, FPJ64_08160 GN {ECO:0000313|EMBL:QOO04539.1}, FPJ65_08145 GN {ECO:0000313|EMBL:QOO00419.1}, FPJ66_08150 GN {ECO:0000313|EMBL:QON96011.1}, FPJ67_08185 GN {ECO:0000313|EMBL:QON91858.1}, FPJ69_08185 GN {ECO:0000313|EMBL:QON87701.1}, FPJ70_08185 GN {ECO:0000313|EMBL:QON83553.1}, FPJ71_08185 GN {ECO:0000313|EMBL:QON79410.1}, FPJ72_06940 GN {ECO:0000313|EMBL:QON75098.1}, FPJ73_08150 GN {ECO:0000313|EMBL:QON71186.1}, FPJ76_08110 GN {ECO:0000313|EMBL:QON67070.1}, FPJ77_08160 GN {ECO:0000313|EMBL:QON62951.1}, FPJ78_08165 GN {ECO:0000313|EMBL:QON58839.1}, FPJ79_08175 GN {ECO:0000313|EMBL:QON54735.1}, FPJ80_08165 GN {ECO:0000313|EMBL:QON50613.1}, FPJ82_08180 GN {ECO:0000313|EMBL:QON42384.1}, FPJ83_13445 GN {ECO:0000313|EMBL:QON39233.1}, FPJ84_08155 GN {ECO:0000313|EMBL:QON34169.1}, FPJ85_13435 GN {ECO:0000313|EMBL:QON30989.1}, FPJ86_13425 GN {ECO:0000313|EMBL:QON26871.1}, FPJ87_13430 GN {ECO:0000313|EMBL:QOK47395.1}, FPJ88_08120 GN {ECO:0000313|EMBL:QON21705.1}, FPJ89_08160 GN {ECO:0000313|EMBL:QON17574.1}, FPJ90_08140 GN {ECO:0000313|EMBL:QON13435.1}, FPJ91_08165 GN {ECO:0000313|EMBL:QON09300.1}, FPJ92_08140 GN {ECO:0000313|EMBL:QON04976.1}, FPJ93_08160 GN {ECO:0000313|EMBL:QON00816.1}, FPJ94_06930 GN {ECO:0000313|EMBL:QOM96349.1}, FPJ95_08155 GN {ECO:0000313|EMBL:QOM92452.1}, FPJ96_08170 GN {ECO:0000313|EMBL:QOM88316.1}, FPJ97_08170 GN {ECO:0000313|EMBL:QOM84165.1}, FPJ98_08140 GN {ECO:0000313|EMBL:QOM80058.1}, FPJ99_08190 GN {ECO:0000313|EMBL:QOM75936.1}, FPK00_08140 GN {ECO:0000313|EMBL:QOM71815.1}, FPK01_08200 GN {ECO:0000313|EMBL:QOM67725.1}, FPK02_08140 GN {ECO:0000313|EMBL:QOM63622.1}, FPK03_08160 GN {ECO:0000313|EMBL:QOM59499.1}, FPK04_08150 GN {ECO:0000313|EMBL:QOM55381.1}, FPK05_08155 GN {ECO:0000313|EMBL:QOM51259.1}, FPK06_08145 GN {ECO:0000313|EMBL:QOM47175.1}, FPK07_08160 GN {ECO:0000313|EMBL:QOM43088.1}, FPK08_08175 GN {ECO:0000313|EMBL:QOM39000.1}, FPK09_08170 GN {ECO:0000313|EMBL:QOM34888.1}, FPK10_06930 GN {ECO:0000313|EMBL:QOM30592.1}, FPK11_08155 GN {ECO:0000313|EMBL:QOM26699.1}, FPK12_08125 GN {ECO:0000313|EMBL:QOM22592.1}, FPK13_08155 GN {ECO:0000313|EMBL:QOM18484.1}, FPK14_08160 GN {ECO:0000313|EMBL:QOM14389.1}, FPK16_08145 GN {ECO:0000313|EMBL:QOM10299.1}, FPK17_08155 GN {ECO:0000313|EMBL:QOM06185.1}, FPK18_08150 GN {ECO:0000313|EMBL:QOM02070.1}, FPK19_08175 GN {ECO:0000313|EMBL:QOL97964.1}, FPK20_08175 GN {ECO:0000313|EMBL:QOL93859.1}, FPK21_08150 GN {ECO:0000313|EMBL:QOL89756.1}, FPK22_08160 GN {ECO:0000313|EMBL:QOL85632.1}, HRD52_07815 GN {ECO:0000313|EMBL:QNF01511.1}, HRD53_07810 GN {ECO:0000313|EMBL:QNF05488.1}, SAMEA2683035_01034 GN {ECO:0000313|EMBL:SGH39969.1}; OS Mycobacterium tuberculosis. OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; OC Mycobacterium; Mycobacterium tuberculosis complex. OX NCBI_TaxID=1773 {ECO:0000313|EMBL:AGJ50654.1}; RN [1] {ECO:0000313|EMBL:AGJ50654.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=TB11-111 {ECO:0000313|EMBL:AGJ50654.1}, and TB11-153 RC {ECO:0000313|EMBL:AGJ50655.1}; RA Daum L.T., Rodriguez J.D., Bhattacharyya S.; RT "Ion Torrent full-gene sequencing and phenotypic drug susceptibility RT testing (DST) confirm multi-drug resistance (MDR) Mycobacterium RT tuberculosis in the United States."; RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AHA90961.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MtbPL.K131 {ECO:0000313|EMBL:AHA90961.1}; RX PubMed=24855126; DOI=10.1093/jac/dku161; RA Jagielski T., Bakula Z., Roeske K., Kaminski M., Napiorkowska A., RA Augustynowicz-Kopec E., Zwolska Z., Bielecki J.; RT "Detection of mutations associated with isoniazid resistance in multidrug- RT resistant Mycobacterium tuberculosis clinical isolates."; RL J. Antimicrob. Chemother. 69:2369-2375(2014). RN [3] {ECO:0000313|EMBL:CNW87781.1, ECO:0000313|Proteomes:UP000044490} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=O00100977 {ECO:0000313|EMBL:CNW87781.1, RC ECO:0000313|Proteomes:UP000044490}; RG Pathogen Informatics; RA Murphy D.; RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Proteomes:UP000040425, ECO:0000313|Proteomes:UP000041288} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2926STDY5723788 {ECO:0000313|EMBL:SGH39969.1, RC ECO:0000313|Proteomes:UP000182946}, Bir 185 RC {ECO:0000313|EMBL:CKR17592.1, ECO:0000313|Proteomes:UP000050164}, Bir RC 187 {ECO:0000313|EMBL:CKS41591.1, ECO:0000313|Proteomes:UP000049023}, RC Bir 89 {ECO:0000313|EMBL:CKN85930.1, RC ECO:0000313|Proteomes:UP000049989}, D00000071 RC {ECO:0000313|EMBL:CNV22734.1, ECO:0000313|Proteomes:UP000046213}, RC E09701106 {ECO:0000313|EMBL:CNV27465.1, RC ECO:0000313|Proteomes:UP000041288}, G00000978 RC {ECO:0000313|EMBL:COU66734.1, ECO:0000313|Proteomes:UP000040425}, RC G09801536 {ECO:0000313|EMBL:COW03350.1, RC ECO:0000313|Proteomes:UP000045842}, G09901357 RC {ECO:0000313|EMBL:CFE41166.1, ECO:0000313|Proteomes:UP000048289}, RC H09601792 {ECO:0000313|EMBL:CFE46976.1, RC ECO:0000313|Proteomes:UP000046947}, and P00601463 RC {ECO:0000313|EMBL:COW17773.1, ECO:0000313|Proteomes:UP000048600}; RG Pathogen Informatics; RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|Proteomes:UP000297584, ECO:0000313|Proteomes:UP000298175} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=EKB34 {ECO:0000313|EMBL:TGE07195.1, RC ECO:0000313|Proteomes:UP000298175}, and EKB53 RC {ECO:0000313|EMBL:TGD81125.1, ECO:0000313|Proteomes:UP000297584}; RA Danilenko V.N., Bekker O.B., Shur K.V., Maslov D.A., Zaychikova M.V., RA Zakharevich N.V.; RT "Draft Genome Sequences of four Mycobacterium tuberculosis isolates."; RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|Proteomes:UP000593586, ECO:0000313|Proteomes:UP000593589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=1-0006P6C4 {ECO:0000313|EMBL:QOP36281.1, RC ECO:0000313|Proteomes:UP000593715}, 1-0007P6C4 RC {ECO:0000313|EMBL:QOP32166.1, ECO:0000313|Proteomes:UP000593648}, RC 1-0009P6C4 {ECO:0000313|EMBL:QOP28047.1, RC ECO:0000313|Proteomes:UP000593593}, 1-0013P6C4 RC {ECO:0000313|EMBL:QOP23950.1, ECO:0000313|Proteomes:UP000593685}, RC 1-0017P6C4 {ECO:0000313|EMBL:QOP19830.1, RC ECO:0000313|Proteomes:UP000594151}, 1-0021P6C4 RC {ECO:0000313|EMBL:QOP15733.1, ECO:0000313|Proteomes:UP000593747}, RC 1-0023P6C4 {ECO:0000313|EMBL:QOP11602.1, RC ECO:0000313|Proteomes:UP000593763}, 1-0028P6C4 RC {ECO:0000313|EMBL:QOP07496.1, ECO:0000313|Proteomes:UP000594137}, RC 1-0030P6C4 {ECO:0000313|EMBL:QOP03381.1, RC ECO:0000313|Proteomes:UP000593843}, 1-0031P6C4 RC {ECO:0000313|EMBL:QOO99250.1, ECO:0000313|Proteomes:UP000593868}, RC 1-0036P6C4 {ECO:0000313|EMBL:QOO95136.1, RC ECO:0000313|Proteomes:UP000593801}, 1-0039P6C4 RC {ECO:0000313|EMBL:QOO91021.1, ECO:0000313|Proteomes:UP000594140}, RC 1-0045P6C4 {ECO:0000313|EMBL:QOO82795.1, RC ECO:0000313|Proteomes:UP000593586}, 1-0047P6C4 RC {ECO:0000313|EMBL:QOO78666.1, ECO:0000313|Proteomes:UP000594070}, RC 1-0054P6C4 {ECO:0000313|EMBL:QOO74551.1, RC ECO:0000313|Proteomes:UP000593681}, 1-0056P6C4 RC {ECO:0000313|EMBL:QOO70440.1, ECO:0000313|Proteomes:UP000593925}, RC 1-0064P6C4 {ECO:0000313|EMBL:QOO62215.1, RC ECO:0000313|Proteomes:UP000593638}, 1-0066P6C4 RC {ECO:0000313|EMBL:QOK38226.1, ECO:0000313|Proteomes:UP000593651}, RC 1-0069P6C4 {ECO:0000313|EMBL:QOO58108.1, RC ECO:0000313|Proteomes:UP000593726}, 1-0071P6C4 RC {ECO:0000313|EMBL:QOO53999.1, ECO:0000313|Proteomes:UP000594032}, RC 1-0072P6C4 {ECO:0000313|EMBL:QOK42344.1, RC ECO:0000313|Proteomes:UP000593637}, 1-0084P6C4 RC {ECO:0000313|EMBL:QOO49883.1, ECO:0000313|Proteomes:UP000593643}, RC 1-0102P6C4 {ECO:0000313|EMBL:QOO45768.1, RC ECO:0000313|Proteomes:UP000593851}, 1-0107P6C4 RC {ECO:0000313|EMBL:QOO41640.1, ECO:0000313|Proteomes:UP000593777}, RC 1-0110P6C4 {ECO:0000313|EMBL:QOO37533.1, RC ECO:0000313|Proteomes:UP000593980}, 1-0112P6C4 RC {ECO:0000313|EMBL:QOO33428.1, ECO:0000313|Proteomes:UP000593983}, RC 1-0116P6C4 {ECO:0000313|EMBL:QOO29317.1, RC ECO:0000313|Proteomes:UP000594061}, 1-0123P6C4 RC {ECO:0000313|EMBL:QOO25195.1, ECO:0000313|Proteomes:UP000593736}, RC 1-0137P6C4 {ECO:0000313|EMBL:QOO21074.1, RC ECO:0000313|Proteomes:UP000593645}, 1-0149P6C4 RC {ECO:0000313|EMBL:QOO16963.1, ECO:0000313|Proteomes:UP000593589}, RC 1-0156P6C4 {ECO:0000313|EMBL:QOO08653.1, RC ECO:0000313|Proteomes:UP000593825}, 1-0160P6C4 RC {ECO:0000313|EMBL:QOO04539.1, ECO:0000313|Proteomes:UP000594013}, RC 1-0168P6C4 {ECO:0000313|EMBL:QOO00419.1, RC ECO:0000313|Proteomes:UP000593773}, 2-0013P6C4 RC {ECO:0000313|EMBL:QON96011.1, ECO:0000313|Proteomes:UP000593786}, RC 2-0021P6C4 {ECO:0000313|EMBL:QON91858.1, RC ECO:0000313|Proteomes:UP000593628}, 2-0023P6C4 RC {ECO:0000313|EMBL:QON87701.1, ECO:0000313|Proteomes:UP000594186}, RC 2-0028P6C4 {ECO:0000313|EMBL:QON83553.1, RC ECO:0000313|Proteomes:UP000593785}, 2-0029P6C4 RC {ECO:0000313|EMBL:QON79410.1, ECO:0000313|Proteomes:UP000594035}, RC 2-0031P6C4 {ECO:0000313|EMBL:QON75098.1, RC ECO:0000313|Proteomes:UP000594104}, 2-0034P6C4 RC {ECO:0000313|EMBL:QON71186.1, ECO:0000313|Proteomes:UP000593608}, RC 2-0052P6C4 {ECO:0000313|EMBL:QON67070.1, RC ECO:0000313|Proteomes:UP000594185}, 2-0059P6C4 RC {ECO:0000313|EMBL:QON62951.1, ECO:0000313|Proteomes:UP000594163}, RC 2-0068P6C4 {ECO:0000313|EMBL:QON58839.1, RC ECO:0000313|Proteomes:UP000593756}, 3-0059P6C4 RC {ECO:0000313|EMBL:QON54735.1, ECO:0000313|Proteomes:UP000593949}, RC 3-0090P6C4 {ECO:0000313|EMBL:QON50613.1, RC ECO:0000313|Proteomes:UP000593956}, 3-0124P6C4 RC {ECO:0000313|EMBL:QON42384.1, ECO:0000313|Proteomes:UP000593914}, RC 4-0010P6C4 {ECO:0000313|EMBL:QON39233.1, RC ECO:0000313|Proteomes:UP000593776}, 4-0012P6C4 RC {ECO:0000313|EMBL:QON34169.1, ECO:0000313|Proteomes:UP000594091}, RC 4-0019P6C4 {ECO:0000313|EMBL:QON30989.1, RC ECO:0000313|Proteomes:UP000593596}, 4-0024P6C4 RC {ECO:0000313|EMBL:QON26871.1, ECO:0000313|Proteomes:UP000594094}, RC 4-0041P6C4 {ECO:0000313|EMBL:QOK47395.1, RC ECO:0000313|Proteomes:UP000593829}, 4-0062P6C4 RC {ECO:0000313|EMBL:QON21705.1, ECO:0000313|Proteomes:UP000593689}, RC 4-0073P6C4 {ECO:0000313|EMBL:QON17574.1, RC ECO:0000313|Proteomes:UP000593770}, 4-0077P6C4 RC {ECO:0000313|EMBL:QON13435.1, ECO:0000313|Proteomes:UP000593791}, RC 4-0087P6C4 {ECO:0000313|EMBL:QON09300.1, RC ECO:0000313|Proteomes:UP000593864}, 4-0096P6C4 RC {ECO:0000313|EMBL:QON04976.1, ECO:0000313|Proteomes:UP000594131}, RC SEA00042P6C4 {ECO:0000313|EMBL:QON00816.1, RC ECO:0000313|Proteomes:UP000594146}, SEA02010036P6C4 RC {ECO:0000313|EMBL:QOM96349.1, ECO:0000313|Proteomes:UP000593815}, RC SEA06535P6C4 {ECO:0000313|EMBL:QOM92452.1, RC ECO:0000313|Proteomes:UP000593683}, SEA07010354P6C4 RC {ECO:0000313|EMBL:QOM88316.1, ECO:0000313|Proteomes:UP000594096}, RC SEA07020250P6C4 {ECO:0000313|EMBL:QOM84165.1, RC ECO:0000313|Proteomes:UP000594124}, SEA08151P6C4 RC {ECO:0000313|EMBL:QOM80058.1, ECO:0000313|Proteomes:UP000594168}, RC SEA08162P6C4 {ECO:0000313|EMBL:QOM75936.1, RC ECO:0000313|Proteomes:UP000593639}, SEA09020048P6C4 RC {ECO:0000313|EMBL:QOM71815.1, ECO:0000313|Proteomes:UP000594065}, RC SEA09167P6C4 {ECO:0000313|EMBL:QOM67725.1, RC ECO:0000313|Proteomes:UP000593729}, SEA11020038P6C4 RC {ECO:0000313|EMBL:QOM63622.1, ECO:0000313|Proteomes:UP000594071}, RC SEA11020057P6C4 {ECO:0000313|EMBL:QOM59499.1, RC ECO:0000313|Proteomes:UP000593629}, SEA11020068P6C4 RC {ECO:0000313|EMBL:QOM55381.1, ECO:0000313|Proteomes:UP000593754}, RC SEA11020092P6C4 {ECO:0000313|EMBL:QOM51259.1, RC ECO:0000313|Proteomes:UP000594069}, SEA11278P6C4 RC {ECO:0000313|EMBL:QOM47175.1, ECO:0000313|Proteomes:UP000593816}, RC SEA12126P6C4 {ECO:0000313|EMBL:QOM43088.1, RC ECO:0000313|Proteomes:UP000593688}, SEA12202P6C4 RC {ECO:0000313|EMBL:QOM39000.1, ECO:0000313|Proteomes:UP000593869}, RC SEA12334P6C4 {ECO:0000313|EMBL:QOM34888.1, RC ECO:0000313|Proteomes:UP000594114}, SEA13020298P6C4 RC {ECO:0000313|EMBL:QOM30592.1, ECO:0000313|Proteomes:UP000593798}, RC SEA13111P6C4 {ECO:0000313|EMBL:QOM26699.1, RC ECO:0000313|Proteomes:UP000593830}, SEA14117P6C4 RC {ECO:0000313|EMBL:QOM22592.1, ECO:0000313|Proteomes:UP000594076}, RC SEA14318P6C4 {ECO:0000313|EMBL:QOM18484.1, RC ECO:0000313|Proteomes:UP000593649}, SEA14333P6C4 RC {ECO:0000313|EMBL:QOM14389.1, ECO:0000313|Proteomes:UP000593710}, RC SEA15228P6C4 {ECO:0000313|EMBL:QOM10299.1, RC ECO:0000313|Proteomes:UP000594064}, SEA15229P6C4 RC {ECO:0000313|EMBL:QOM06185.1, ECO:0000313|Proteomes:UP000594033}, RC SEA15230P6C4 {ECO:0000313|EMBL:QOM02070.1, RC ECO:0000313|Proteomes:UP000594090}, SEA17020023P6C4 RC {ECO:0000313|EMBL:QOL97964.1, ECO:0000313|Proteomes:UP000593696}, RC SEA17020024P6C4 {ECO:0000313|EMBL:QOL93859.1, RC ECO:0000313|Proteomes:UP000593703}, SEA17020028P6C4 RC {ECO:0000313|EMBL:QOL89756.1, ECO:0000313|Proteomes:UP000593987}, and RC SEA17020030P6C4 {ECO:0000313|EMBL:QOL85632.1, RC ECO:0000313|Proteomes:UP000594038}; RA Valafar F.; RT "Mycobacterium tuberculosis reference-quality genomes."; RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|Proteomes:UP000515298, ECO:0000313|Proteomes:UP000515527} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=H37Rv_IC1 {ECO:0000313|EMBL:QNF05488.1, RC ECO:0000313|Proteomes:UP000515298}, and H37Rv_IC2 RC {ECO:0000313|EMBL:QNF01511.1, ECO:0000313|Proteomes:UP000515527}; RA Pasca M.R.; RT "IC1-2 M. tuberculosis clinical isolates."; RL Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + CC NADH; Xref=Rhea:RHEA:18177, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, CC ChEBI:CHEBI:57945, ChEBI:CHEBI:58856, ChEBI:CHEBI:65111; CC Evidence={ECO:0000256|ARBA:ARBA00001288}; CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:18179; CC Evidence={ECO:0000256|ARBA:ARBA00001288}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + CC H(+) + NADH; Xref=Rhea:RHEA:10240, Rhea:RHEA-COMP:9925, Rhea:RHEA- CC COMP:9926, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, CC ChEBI:CHEBI:78784, ChEBI:CHEBI:78785; EC=1.3.1.9; CC Evidence={ECO:0000256|PIRNR:PIRNR000094}; CC -!- PATHWAY: Lipid metabolism; mycolic acid biosynthesis. CC {ECO:0000256|ARBA:ARBA00004796}. CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) CC family. FabI subfamily. {ECO:0000256|ARBA:ARBA00009233, CC ECO:0000256|PIRNR:PIRNR000094}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KC692360; AGJ50654.1; -; Genomic_DNA. DR EMBL; KC692361; AGJ50655.1; -; Genomic_DNA. DR EMBL; KF563064; AHA90961.1; -; Genomic_DNA. DR EMBL; CFOE01000404; CFE41166.1; -; Genomic_DNA. DR EMBL; CFOH01000050; CFE46976.1; -; Genomic_DNA. DR EMBL; CNCN01000080; CKN85930.1; -; Genomic_DNA. DR EMBL; CNFT01000132; CKR17592.1; -; Genomic_DNA. DR EMBL; CNFU01000735; CKS41591.1; -; Genomic_DNA. DR EMBL; CQPV01000436; CNV22734.1; -; Genomic_DNA. DR EMBL; CQPL01000668; CNV27465.1; -; Genomic_DNA. DR EMBL; CQSC01000078; CNW87781.1; -; Genomic_DNA. DR EMBL; CRZK01000039; COU66734.1; -; Genomic_DNA. DR EMBL; CSAD01000466; COW03350.1; -; Genomic_DNA. DR EMBL; CHKL01000161; COW17773.1; -; Genomic_DNA. DR EMBL; CP053902; QNF01511.1; -; Genomic_DNA. DR EMBL; CP053903; QNF05488.1; -; Genomic_DNA. DR EMBL; CP043997; QOK38226.1; -; Genomic_DNA. DR EMBL; CP043996; QOK42344.1; -; Genomic_DNA. DR EMBL; CP043995; QOK47395.1; -; Genomic_DNA. DR EMBL; CP041788; QOL85632.1; -; Genomic_DNA. DR EMBL; CP041789; QOL89756.1; -; Genomic_DNA. DR EMBL; CP041790; QOL93859.1; -; Genomic_DNA. DR EMBL; CP041791; QOL97964.1; -; Genomic_DNA. DR EMBL; CP041792; QOM02070.1; -; Genomic_DNA. DR EMBL; CP041793; QOM06185.1; -; Genomic_DNA. DR EMBL; CP041794; QOM10299.1; -; Genomic_DNA. DR EMBL; CP041795; QOM14389.1; -; Genomic_DNA. DR EMBL; CP041796; QOM18484.1; -; Genomic_DNA. DR EMBL; CP041797; QOM22592.1; -; Genomic_DNA. DR EMBL; CP041798; QOM26699.1; -; Genomic_DNA. DR EMBL; CP041799; QOM30592.1; -; Genomic_DNA. DR EMBL; CP041800; QOM34888.1; -; Genomic_DNA. DR EMBL; CP041801; QOM39000.1; -; Genomic_DNA. DR EMBL; CP041802; QOM43088.1; -; Genomic_DNA. DR EMBL; CP041803; QOM47175.1; -; Genomic_DNA. DR EMBL; CP041804; QOM51259.1; -; Genomic_DNA. DR EMBL; CP041805; QOM55381.1; -; Genomic_DNA. DR EMBL; CP041806; QOM59499.1; -; Genomic_DNA. DR EMBL; CP041807; QOM63622.1; -; Genomic_DNA. DR EMBL; CP041808; QOM67725.1; -; Genomic_DNA. DR EMBL; CP041809; QOM71815.1; -; Genomic_DNA. DR EMBL; CP041810; QOM75936.1; -; Genomic_DNA. DR EMBL; CP041811; QOM80058.1; -; Genomic_DNA. DR EMBL; CP041812; QOM84165.1; -; Genomic_DNA. DR EMBL; CP041813; QOM88316.1; -; Genomic_DNA. DR EMBL; CP041814; QOM92452.1; -; Genomic_DNA. DR EMBL; CP041815; QOM96349.1; -; Genomic_DNA. DR EMBL; CP041816; QON00816.1; -; Genomic_DNA. DR EMBL; CP041817; QON04976.1; -; Genomic_DNA. DR EMBL; CP041818; QON09300.1; -; Genomic_DNA. DR EMBL; CP041819; QON13435.1; -; Genomic_DNA. DR EMBL; CP041820; QON17574.1; -; Genomic_DNA. DR EMBL; CP041821; QON21705.1; -; Genomic_DNA. DR EMBL; CP041822; QON26871.1; -; Genomic_DNA. DR EMBL; CP041823; QON30989.1; -; Genomic_DNA. DR EMBL; CP041824; QON34169.1; -; Genomic_DNA. DR EMBL; CP041825; QON39233.1; -; Genomic_DNA. DR EMBL; CP041826; QON42384.1; -; Genomic_DNA. DR EMBL; CP041828; QON50613.1; -; Genomic_DNA. DR EMBL; CP041829; QON54735.1; -; Genomic_DNA. DR EMBL; CP041830; QON58839.1; -; Genomic_DNA. DR EMBL; CP041831; QON62951.1; -; Genomic_DNA. DR EMBL; CP041832; QON67070.1; -; Genomic_DNA. DR EMBL; CP041835; QON71186.1; -; Genomic_DNA. DR EMBL; CP041836; QON75098.1; -; Genomic_DNA. DR EMBL; CP041837; QON79410.1; -; Genomic_DNA. DR EMBL; CP041838; QON83553.1; -; Genomic_DNA. DR EMBL; CP041839; QON87701.1; -; Genomic_DNA. DR EMBL; CP041841; QON91858.1; -; Genomic_DNA. DR EMBL; CP041842; QON96011.1; -; Genomic_DNA. DR EMBL; CP041843; QOO00419.1; -; Genomic_DNA. DR EMBL; CP041844; QOO04539.1; -; Genomic_DNA. DR EMBL; CP041845; QOO08653.1; -; Genomic_DNA. DR EMBL; CP041847; QOO16963.1; -; Genomic_DNA. DR EMBL; CP041848; QOO21074.1; -; Genomic_DNA. DR EMBL; CP041849; QOO25195.1; -; Genomic_DNA. DR EMBL; CP041850; QOO29317.1; -; Genomic_DNA. DR EMBL; CP041851; QOO33428.1; -; Genomic_DNA. DR EMBL; CP041852; QOO37533.1; -; Genomic_DNA. DR EMBL; CP041853; QOO41640.1; -; Genomic_DNA. DR EMBL; CP041854; QOO45768.1; -; Genomic_DNA. DR EMBL; CP041855; QOO49883.1; -; Genomic_DNA. DR EMBL; CP041856; QOO53999.1; -; Genomic_DNA. DR EMBL; CP041857; QOO58108.1; -; Genomic_DNA. DR EMBL; CP041858; QOO62215.1; -; Genomic_DNA. DR EMBL; CP041860; QOO70440.1; -; Genomic_DNA. DR EMBL; CP041861; QOO74551.1; -; Genomic_DNA. DR EMBL; CP041862; QOO78666.1; -; Genomic_DNA. DR EMBL; CP041863; QOO82795.1; -; Genomic_DNA. DR EMBL; CP041865; QOO91021.1; -; Genomic_DNA. DR EMBL; CP041866; QOO95136.1; -; Genomic_DNA. DR EMBL; CP041867; QOO99250.1; -; Genomic_DNA. DR EMBL; CP041868; QOP03381.1; -; Genomic_DNA. DR EMBL; CP041869; QOP07496.1; -; Genomic_DNA. DR EMBL; CP041870; QOP11602.1; -; Genomic_DNA. DR EMBL; CP041871; QOP15733.1; -; Genomic_DNA. DR EMBL; CP041872; QOP19830.1; -; Genomic_DNA. DR EMBL; CP041873; QOP23950.1; -; Genomic_DNA. DR EMBL; CP041874; QOP28047.1; -; Genomic_DNA. DR EMBL; CP041875; QOP32166.1; -; Genomic_DNA. DR EMBL; CP041876; QOP36281.1; -; Genomic_DNA. DR EMBL; FPTZ01000005; SGH39969.1; -; Genomic_DNA. DR EMBL; SRLJ01000004; TGD81125.1; -; Genomic_DNA. DR EMBL; SRLI01000004; TGE07195.1; -; Genomic_DNA. DR RefSeq; WP_003407553.1; NZ_WUJD01000014.1. DR ChEMBL; CHEMBL3879823; -. DR EnsemblBacteria; CKR15684; CKR15684; ERS027654_00753. DR EnsemblBacteria; CKR17592; CKR17592; ERS027659_00857. DR EnsemblBacteria; CKR40504; CKR40504; ERS027644_01157. DR EnsemblBacteria; CKR62543; CKR62543; ERS027656_01728. DR EnsemblBacteria; CKR67679; CKR67679; ERS027651_01123. DR EnsemblBacteria; CKS39180; CKS39180; ERS027653_02937. DR EnsemblBacteria; CKS41591; CKS41591; ERS027661_03047. DR EnsemblBacteria; CKV85791; CKV85791; ERS031537_03411. DR EnsemblBacteria; CNG10554; CNG10554; ERS124361_00179. DR EnsemblBacteria; CNN12986; CNN12986; ERS023446_02245. DR EnsemblBacteria; COW17773; COW17773; ERS007741_01725. DR EnsemblBacteria; REN01509; REN01509; DSI35_19790. DR EnsemblBacteria; SGH39969; SGH39969; SAMEA2683035_01034. DR EnsemblBacteria; SGM14702; SGM14702; SAMEA2682864_01868. DR GeneID; 45425463; -. DR PATRIC; fig|1773.206.peg.1259; -. DR UniPathway; UPA00915; -. DR Proteomes; UP000040425; Unassembled WGS sequence. DR Proteomes; UP000041288; Unassembled WGS sequence. DR Proteomes; UP000044490; Unassembled WGS sequence. DR Proteomes; UP000045842; Unassembled WGS sequence. DR Proteomes; UP000046213; Unassembled WGS sequence. DR Proteomes; UP000046947; Unassembled WGS sequence. DR Proteomes; UP000048289; Unassembled WGS sequence. DR Proteomes; UP000048600; Unassembled WGS sequence. DR Proteomes; UP000049023; Unassembled WGS sequence. DR Proteomes; UP000049989; Unassembled WGS sequence. DR Proteomes; UP000050164; Unassembled WGS sequence. DR Proteomes; UP000182946; Unassembled WGS sequence. DR Proteomes; UP000297584; Unassembled WGS sequence. DR Proteomes; UP000298175; Unassembled WGS sequence. DR Proteomes; UP000515298; Chromosome. DR Proteomes; UP000515527; Chromosome. DR Proteomes; UP000593586; Chromosome. DR Proteomes; UP000593589; Chromosome. DR Proteomes; UP000593593; Chromosome. DR Proteomes; UP000593596; Chromosome. DR Proteomes; UP000593608; Chromosome. DR Proteomes; UP000593628; Chromosome. DR Proteomes; UP000593629; Chromosome. DR Proteomes; UP000593637; Chromosome. DR Proteomes; UP000593638; Chromosome. DR Proteomes; UP000593639; Chromosome. DR Proteomes; UP000593643; Chromosome. DR Proteomes; UP000593645; Chromosome. DR Proteomes; UP000593648; Chromosome. DR Proteomes; UP000593649; Chromosome. DR Proteomes; UP000593651; Chromosome. DR Proteomes; UP000593681; Chromosome. DR Proteomes; UP000593683; Chromosome. DR Proteomes; UP000593685; Chromosome. DR Proteomes; UP000593688; Chromosome. DR Proteomes; UP000593689; Chromosome. DR Proteomes; UP000593696; Chromosome. DR Proteomes; UP000593703; Chromosome. DR Proteomes; UP000593710; Chromosome. DR Proteomes; UP000593715; Chromosome. DR Proteomes; UP000593726; Chromosome. DR Proteomes; UP000593729; Chromosome. DR Proteomes; UP000593736; Chromosome. DR Proteomes; UP000593747; Chromosome. DR Proteomes; UP000593754; Chromosome. DR Proteomes; UP000593756; Chromosome. DR Proteomes; UP000593763; Chromosome. DR Proteomes; UP000593770; Chromosome. DR Proteomes; UP000593773; Chromosome. DR Proteomes; UP000593776; Chromosome. DR Proteomes; UP000593777; Chromosome. DR Proteomes; UP000593785; Chromosome. DR Proteomes; UP000593786; Chromosome. DR Proteomes; UP000593791; Chromosome. DR Proteomes; UP000593798; Chromosome. DR Proteomes; UP000593801; Chromosome. DR Proteomes; UP000593815; Chromosome. DR Proteomes; UP000593816; Chromosome. DR Proteomes; UP000593825; Chromosome. DR Proteomes; UP000593829; Chromosome. DR Proteomes; UP000593830; Chromosome. DR Proteomes; UP000593843; Chromosome. DR Proteomes; UP000593851; Chromosome. DR Proteomes; UP000593864; Chromosome. DR Proteomes; UP000593868; Chromosome. DR Proteomes; UP000593869; Chromosome. DR Proteomes; UP000593914; Chromosome. DR Proteomes; UP000593925; Chromosome. DR Proteomes; UP000593949; Chromosome. DR Proteomes; UP000593956; Chromosome. DR Proteomes; UP000593980; Chromosome. DR Proteomes; UP000593983; Chromosome. DR Proteomes; UP000593987; Chromosome. DR Proteomes; UP000594013; Chromosome. DR Proteomes; UP000594032; Chromosome. DR Proteomes; UP000594033; Chromosome. DR Proteomes; UP000594035; Chromosome. DR Proteomes; UP000594038; Chromosome. DR Proteomes; UP000594061; Chromosome. DR Proteomes; UP000594064; Chromosome. DR Proteomes; UP000594065; Chromosome. DR Proteomes; UP000594069; Chromosome. DR Proteomes; UP000594070; Chromosome. DR Proteomes; UP000594071; Chromosome. DR Proteomes; UP000594076; Chromosome. DR Proteomes; UP000594090; Chromosome. DR Proteomes; UP000594091; Chromosome. DR Proteomes; UP000594094; Chromosome. DR Proteomes; UP000594096; Chromosome. DR Proteomes; UP000594104; Chromosome. DR Proteomes; UP000594114; Chromosome. DR Proteomes; UP000594124; Chromosome. DR Proteomes; UP000594131; Chromosome. DR Proteomes; UP000594137; Chromosome. DR Proteomes; UP000594140; Chromosome. DR Proteomes; UP000594146; Chromosome. DR Proteomes; UP000594151; Chromosome. DR Proteomes; UP000594163; Chromosome. DR Proteomes; UP000594168; Chromosome. DR Proteomes; UP000594185; Chromosome. DR Proteomes; UP000594186; Chromosome. DR GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NADH) activity; IEA:UniProtKB-EC. DR GO; GO:0016631; F:enoyl-[acyl-carrier-protein] reductase activity; IEA:UniProtKB-EC. DR GO; GO:0050343; F:trans-2-enoyl-CoA reductase (NAD+) activity; IEA:RHEA. DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW. DR CDD; cd05372; ENR_SDR; 1. DR InterPro; IPR014358; Enoyl-ACP_Rdtase_NADH. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR PANTHER; PTHR43159; PTHR43159; 1. DR PIRSF; PIRSF000094; Enoyl-ACP_rdct; 1. DR SUPFAM; SSF51735; SSF51735; 1. PE 3: Inferred from homology; KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160, KW ECO:0000256|PIRNR:PIRNR000094}; KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00023160, KW ECO:0000256|PIRNR:PIRNR000094}; KW Lipid biosynthesis {ECO:0000256|PIRNR:PIRNR000094}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023160, KW ECO:0000256|PIRNR:PIRNR000094}; KW NAD {ECO:0000256|PIRNR:PIRNR000094, ECO:0000256|PIRSR:PIRSR000094-3}; KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002, KW ECO:0000256|PIRNR:PIRNR000094}. FT NP_BIND 20..21 FT /note="NAD" FT /evidence="ECO:0000256|PIRSR:PIRSR000094-3" FT NP_BIND 64..65 FT /note="NAD" FT /evidence="ECO:0000256|PIRSR:PIRSR000094-3" FT NP_BIND 194..198 FT /note="NAD" FT /evidence="ECO:0000256|PIRSR:PIRSR000094-3" FT BINDING 14 FT /note="NAD; via carbonyl oxygen" FT /evidence="ECO:0000256|PIRSR:PIRSR000094-3" FT BINDING 95 FT /note="NAD; via carbonyl oxygen" FT /evidence="ECO:0000256|PIRSR:PIRSR000094-3" FT BINDING 165 FT /note="NAD" FT /evidence="ECO:0000256|PIRSR:PIRSR000094-3" SQ SEQUENCE 269 AA; 28528 MW; F161D6D6A631CA08 CRC64; MTGLLDGKRI LVSGIITDSS IAFHIARVAQ EQGAQLVLTG FDRLRLIQRI TDRLPAKAPL LELDVQNEEH LASLAGRVTE AIGAGNKLDG VVHSIGFMPQ TGMGINPFFD APYADVSKGI HISAYSYASM AKALLPIMNP GGSIVGMDFD PSRAMPAYNW MTVAKSALES VNRFVAREAG KYGVRSNLVA AGPIRTLAMS AIVGGALGEE AGAQIQLLEE GWDQRAPIGW NMKDATPVAK TVCALLSDWL PATTGDIIYA DGGAHTQLL //