ID M9TGV3_MYCTX Unreviewed; 269 AA. AC M9TGV3; DT 26-JUN-2013, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 1. DT 16-OCT-2019, entry version 64. DE RecName: Full=Enoyl-[acyl-carrier-protein] reductase [NADH] {ECO:0000256|PIRNR:PIRNR000094}; DE EC=1.3.1.9 {ECO:0000256|PIRNR:PIRNR000094}; GN Name=inhA {ECO:0000313|EMBL:AGJ50654.1}; GN Synonyms=fabI {ECO:0000313|EMBL:TKR41460.1}, inhA_2 GN {ECO:0000313|EMBL:SGD54097.1}; GN ORFNames=DSI35_19790 {ECO:0000313|EMBL:REN01509.1}, ERS007663_02660 GN {ECO:0000313|EMBL:CNV22734.1}, ERS007670_02839 GN {ECO:0000313|EMBL:CNV27465.1}, ERS007679_02961 GN {ECO:0000313|EMBL:COW03350.1}, ERS007681_02786 GN {ECO:0000313|EMBL:CFE41166.1}, ERS007688_00531 GN {ECO:0000313|EMBL:CFE46976.1}, ERS007741_01725 GN {ECO:0000313|EMBL:COW17773.1}, ERS023446_02245 GN {ECO:0000313|EMBL:CNN12986.1}, ERS024276_00561 GN {ECO:0000313|EMBL:CKN85930.1}, ERS027644_01157 GN {ECO:0000313|EMBL:CKR40504.1}, ERS027651_01123 GN {ECO:0000313|EMBL:CKR67679.1}, ERS027652_03095 GN {ECO:0000313|EMBL:CKS36630.1}, ERS027653_02937 GN {ECO:0000313|EMBL:CKS39180.1}, ERS027654_00753 GN {ECO:0000313|EMBL:CKR15684.1}, ERS027656_01728 GN {ECO:0000313|EMBL:CKR62543.1}, ERS027659_00857 GN {ECO:0000313|EMBL:CKR17592.1}, ERS027661_03047 GN {ECO:0000313|EMBL:CKS41591.1}, ERS027666_01181 GN {ECO:0000313|EMBL:CKS53350.1}, ERS031537_03411 GN {ECO:0000313|EMBL:CKV85791.1}, ERS124361_00179 GN {ECO:0000313|EMBL:CNG10554.1}, FDK60_03570 GN {ECO:0000313|EMBL:TKR41460.1}, SAMEA2682835_04047 GN {ECO:0000313|EMBL:SGD54097.1}, SAMEA2682864_01868 GN {ECO:0000313|EMBL:SGM14702.1}, SAMEA2683035_01034 GN {ECO:0000313|EMBL:SGH39969.1}; OS Mycobacterium tuberculosis. OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; OC Mycobacterium; Mycobacterium tuberculosis complex. OX NCBI_TaxID=1773 {ECO:0000313|EMBL:AGJ50654.1}; RN [1] {ECO:0000313|EMBL:AGJ50654.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=TB11-111 {ECO:0000313|EMBL:AGJ50654.1}, and TB11-153 RC {ECO:0000313|EMBL:AGJ50655.1}; RA Daum L.T., Rodriguez J.D., Bhattacharyya S.; RT "Ion Torrent full-gene sequencing and phenotypic drug susceptibility RT testing (DST) confirm multi-drug resistance (MDR) Mycobacterium RT tuberculosis in the United States."; RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AHA90961.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MtbPL.K131 {ECO:0000313|EMBL:AHA90961.1}; RX PubMed=24855126; DOI=10.1093/jac/dku161; RA Jagielski T., Bakula Z., Roeske K., Kaminski M., Napiorkowska A., RA Augustynowicz-Kopec E., Zwolska Z., Bielecki J.; RT "Detection of mutations associated with isoniazid resistance in RT multidrug-resistant Mycobacterium tuberculosis clinical isolates."; RL J. Antimicrob. Chemother. 69:2369-2375(2014). RN [3] {ECO:0000313|Proteomes:UP000048600, ECO:0000313|Proteomes:UP000049023, ECO:0000313|Proteomes:UP000049058} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2926STDY5723586 {ECO:0000313|EMBL:SGD54097.1, RC ECO:0000313|Proteomes:UP000298647}, 2926STDY5723616 RC {ECO:0000313|EMBL:SGM14702.1, ECO:0000313|Proteomes:UP000183655}, RC 2926STDY5723788 {ECO:0000313|EMBL:SGH39969.1, RC ECO:0000313|Proteomes:UP000182946}, Bir 170 RC {ECO:0000313|Proteomes:UP000050038}, Bir 177 RC {ECO:0000313|EMBL:CKR67679.1, ECO:0000313|Proteomes:UP000049058}, Bir RC 179 {ECO:0000313|Proteomes:UP000049114}, Bir 180 RC {ECO:0000313|Proteomes:UP000049258}, Bir 182 RC {ECO:0000313|Proteomes:UP000050143}, Bir 185 RC {ECO:0000313|Proteomes:UP000050164}, Bir 187 RC {ECO:0000313|Proteomes:UP000049023}, Bir 277 RC {ECO:0000313|Proteomes:UP000049498}, and P00601463 RC {ECO:0000313|Proteomes:UP000048600}; RG Pathogen Informatics; RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:CFE41166.1, ECO:0000313|Proteomes:UP000039953, ECO:0000313|Proteomes:UP000047075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=200127 {ECO:0000313|EMBL:CNG10554.1, RC ECO:0000313|Proteomes:UP000047075}, A70144_2 RC {ECO:0000313|EMBL:CNN12986.1, ECO:0000313|Proteomes:UP000039953}, Bir RC 170 {ECO:0000313|EMBL:CKR40504.1}, Bir 178 RC {ECO:0000313|EMBL:CKS36630.1}, Bir 179 {ECO:0000313|EMBL:CKS39180.1}, RC Bir 180 {ECO:0000313|EMBL:CKR15684.1}, Bir 182 RC {ECO:0000313|EMBL:CKR62543.1}, Bir 185 {ECO:0000313|EMBL:CKR17592.1}, RC Bir 187 {ECO:0000313|EMBL:CKS41591.1}, Bir 192 RC {ECO:0000313|EMBL:CKS53350.1}, Bir 277 {ECO:0000313|EMBL:CKV85791.1}, RC Bir 89 {ECO:0000313|EMBL:CKN85930.1}, D00000071 RC {ECO:0000313|EMBL:CNV22734.1}, E09701106 RC {ECO:0000313|EMBL:CNV27465.1}, G09801536 RC {ECO:0000313|EMBL:COW03350.1}, G09901357 RC {ECO:0000313|EMBL:CFE41166.1}, H09601792 RC {ECO:0000313|EMBL:CFE46976.1}, and P00601463 RC {ECO:0000313|EMBL:COW17773.1}; RA Murphy D.; RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:REN01509.1, ECO:0000313|Proteomes:UP000256252} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=31007_S18 {ECO:0000313|EMBL:REN01509.1, RC ECO:0000313|Proteomes:UP000256252}; RX PubMed=28099825; DOI=10.1056/NEJMoa1604544; RA Shah N.S., Auld S.C., Brust J.C., Mathema B., Ismail N., Moodley P., RA Mlisana K., Allana S., Campbell A., Mthiyane T., Morris N., RA Mpangase P., van der Meulen H., Omar S.V., Brown T.S., Narechania A., RA Shaskina E., Kapwata T., Kreiswirth B., Gandhi N.R.; RT "Transmission of Extensively Drug-Resistant Tuberculosis in South RT Africa."; RL N. Engl. J. Med. 376:243-253(2017). RN [6] {ECO:0000313|EMBL:REN01509.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=31007_S18 {ECO:0000313|EMBL:REN01509.1}; RA Quirk P.G., Krulwich T.A.; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:TKR41460.1, ECO:0000313|Proteomes:UP000305204} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=TBR038 {ECO:0000313|EMBL:TKR41460.1, RC ECO:0000313|Proteomes:UP000305204}; RA Solano-Gutierrez J.S., Rodriguez A., Robledo J.; RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] CC + H(+) + NADH; Xref=Rhea:RHEA:10240, Rhea:RHEA-COMP:9925, CC Rhea:RHEA-COMP:9926, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, CC ChEBI:CHEBI:57945, ChEBI:CHEBI:78784, ChEBI:CHEBI:78785; CC EC=1.3.1.9; Evidence={ECO:0000256|PIRNR:PIRNR000094}; CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases CC (SDR) family. FabI subfamily. {ECO:0000256|PIRNR:PIRNR000094}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KC692360; AGJ50654.1; -; Genomic_DNA. DR EMBL; KC692361; AGJ50655.1; -; Genomic_DNA. DR EMBL; KF563064; AHA90961.1; -; Genomic_DNA. DR EMBL; CFOE01000404; CFE41166.1; -; Genomic_DNA. DR EMBL; CFOH01000050; CFE46976.1; -; Genomic_DNA. DR EMBL; CNCN01000080; CKN85930.1; -; Genomic_DNA. DR EMBL; CNFR01000102; CKR15684.1; -; Genomic_DNA. DR EMBL; CNFT01000132; CKR17592.1; -; Genomic_DNA. DR EMBL; CNFW01000149; CKR40504.1; -; Genomic_DNA. DR EMBL; CNFV01000238; CKR62543.1; -; Genomic_DNA. DR EMBL; CIEA01000007; CKR67679.1; -; Genomic_DNA. DR EMBL; CNFQ01000771; CKS36630.1; -; Genomic_DNA. DR EMBL; CNFS01000728; CKS39180.1; -; Genomic_DNA. DR EMBL; CNFU01000735; CKS41591.1; -; Genomic_DNA. DR EMBL; CNGG01000184; CKS53350.1; -; Genomic_DNA. DR EMBL; CNIS01000709; CKV85791.1; -; Genomic_DNA. DR EMBL; CHDS01000002; CNG10554.1; -; Genomic_DNA. DR EMBL; CQGE01000047; CNN12986.1; -; Genomic_DNA. DR EMBL; CQPV01000436; CNV22734.1; -; Genomic_DNA. DR EMBL; CQPL01000668; CNV27465.1; -; Genomic_DNA. DR EMBL; CSAD01000466; COW03350.1; -; Genomic_DNA. DR EMBL; CHKL01000161; COW17773.1; -; Genomic_DNA. DR EMBL; QSXG01001394; REN01509.1; -; Genomic_DNA. DR EMBL; FPPU01000018; SGD54097.1; -; Genomic_DNA. DR EMBL; FPTZ01000005; SGH39969.1; -; Genomic_DNA. DR EMBL; FPXX01000010; SGM14702.1; -; Genomic_DNA. DR EMBL; SZTS01000008; TKR41460.1; -; Genomic_DNA. DR RefSeq; WP_003407553.1; NZ_VHOB01000017.1. DR ChEMBL; CHEMBL3879823; -. DR EnsemblBacteria; AMC45863; AMC45863; RN05_1587. DR EnsemblBacteria; CFE41166; CFE41166; ERS007681_02786. DR EnsemblBacteria; CFE46976; CFE46976; ERS007688_00531. DR EnsemblBacteria; CKN85930; CKN85930; ERS024276_00561. DR EnsemblBacteria; CKR15684; CKR15684; ERS027654_00753. DR EnsemblBacteria; CKR17592; CKR17592; ERS027659_00857. DR EnsemblBacteria; CKR40504; CKR40504; ERS027644_01157. DR EnsemblBacteria; CKR62543; CKR62543; ERS027656_01728. DR EnsemblBacteria; CKS36630; CKS36630; ERS027652_03095. DR EnsemblBacteria; CKS39180; CKS39180; ERS027653_02937. DR EnsemblBacteria; CKS41591; CKS41591; ERS027661_03047. DR EnsemblBacteria; CKS53350; CKS53350; ERS027666_01181. DR EnsemblBacteria; CKV85791; CKV85791; ERS031537_03411. DR EnsemblBacteria; CNG10554; CNG10554; ERS124361_00179. DR EnsemblBacteria; CNN12986; CNN12986; ERS023446_02245. DR EnsemblBacteria; CNV22734; CNV22734; ERS007663_02660. DR EnsemblBacteria; CNV27465; CNV27465; ERS007670_02839. DR EnsemblBacteria; CNY49422; CNY49422; ERS013471_01761. DR EnsemblBacteria; COW03350; COW03350; ERS007679_02961. DR EnsemblBacteria; COW17773; COW17773; ERS007741_01725. DR EnsemblBacteria; CRH12375; CRH12375; BN1303_01560. DR EnsemblBacteria; CRH14939; CRH14939; BN1213_03046. DR PATRIC; fig|1773.206.peg.1259; -. DR eggNOG; ENOG4105CSJ; Bacteria. DR eggNOG; COG0623; LUCA. DR Proteomes; UP000039953; Unassembled WGS sequence. DR Proteomes; UP000047075; Unassembled WGS sequence. DR Proteomes; UP000048600; Unassembled WGS sequence. DR Proteomes; UP000049023; Unassembled WGS sequence. DR Proteomes; UP000049058; Unassembled WGS sequence. DR Proteomes; UP000049114; Unassembled WGS sequence. DR Proteomes; UP000049258; Unassembled WGS sequence. DR Proteomes; UP000049498; Unassembled WGS sequence. DR Proteomes; UP000050038; Unassembled WGS sequence. DR Proteomes; UP000050143; Unassembled WGS sequence. DR Proteomes; UP000050164; Unassembled WGS sequence. DR Proteomes; UP000182946; Unassembled WGS sequence. DR Proteomes; UP000183655; Unassembled WGS sequence. DR Proteomes; UP000256252; Unassembled WGS sequence. DR Proteomes; UP000298647; Unassembled WGS sequence. DR Proteomes; UP000305204; Unassembled WGS sequence. DR GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NADH) activity; IEA:UniProtKB-EC. DR GO; GO:0016631; F:enoyl-[acyl-carrier-protein] reductase activity; IEA:UniProtKB-EC. DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW. DR CDD; cd05372; ENR_SDR; 1. DR InterPro; IPR014358; Enoyl-ACP_Rdtase_NADH. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR PANTHER; PTHR43159:SF2; PTHR43159:SF2; 1. DR PIRSF; PIRSF000094; Enoyl-ACP_rdct; 1. DR SUPFAM; SSF51735; SSF51735; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000039953, KW ECO:0000313|Proteomes:UP000047075, ECO:0000313|Proteomes:UP000048600, KW ECO:0000313|Proteomes:UP000049023}; KW Fatty acid biosynthesis {ECO:0000256|PIRNR:PIRNR000094}; KW Fatty acid metabolism {ECO:0000256|PIRNR:PIRNR000094}; KW Lipid biosynthesis {ECO:0000256|PIRNR:PIRNR000094}; KW Lipid metabolism {ECO:0000256|PIRNR:PIRNR000094}; KW NAD {ECO:0000256|PIRNR:PIRNR000094, ECO:0000256|PIRSR:PIRSR000094-3}; KW Oxidoreductase {ECO:0000256|PIRNR:PIRNR000094, KW ECO:0000313|EMBL:CFE41166.1}. FT NP_BIND 20 21 NAD. {ECO:0000256|PIRSR:PIRSR000094-3}. FT NP_BIND 64 65 NAD. {ECO:0000256|PIRSR:PIRSR000094-3}. FT NP_BIND 194 198 NAD. {ECO:0000256|PIRSR:PIRSR000094-3}. FT BINDING 14 14 NAD; via carbonyl oxygen. FT {ECO:0000256|PIRSR:PIRSR000094-3}. FT BINDING 95 95 NAD; via carbonyl oxygen. FT {ECO:0000256|PIRSR:PIRSR000094-3}. FT BINDING 165 165 NAD. {ECO:0000256|PIRSR:PIRSR000094-3}. SQ SEQUENCE 269 AA; 28528 MW; F161D6D6A631CA08 CRC64; MTGLLDGKRI LVSGIITDSS IAFHIARVAQ EQGAQLVLTG FDRLRLIQRI TDRLPAKAPL LELDVQNEEH LASLAGRVTE AIGAGNKLDG VVHSIGFMPQ TGMGINPFFD APYADVSKGI HISAYSYASM AKALLPIMNP GGSIVGMDFD PSRAMPAYNW MTVAKSALES VNRFVAREAG KYGVRSNLVA AGPIRTLAMS AIVGGALGEE AGAQIQLLEE GWDQRAPIGW NMKDATPVAK TVCALLSDWL PATTGDIIYA DGGAHTQLL //