ID M9PFW3_DROME Unreviewed; 806 AA. AC M9PFW3; DT 26-JUN-2013, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 1. DT 20-JUN-2018, entry version 46. DE SubName: Full=Frizzled 2, isoform F {ECO:0000313|EMBL:AGB94730.1}; GN Name=fz2 {ECO:0000313|EMBL:AGB94730.1, GN ECO:0000313|FlyBase:FBgn0016797}; GN Synonyms=D-Fz2 {ECO:0000313|EMBL:AGB94730.1}, D-fz2 GN {ECO:0000313|EMBL:AGB94730.1}, Dfrz2 {ECO:0000313|EMBL:AGB94730.1}, GN dfz(2) {ECO:0000313|EMBL:AGB94730.1}, DFz-2 GN {ECO:0000313|EMBL:AGB94730.1}, DFZ2 {ECO:0000313|EMBL:AGB94730.1}, GN DFz2 {ECO:0000313|EMBL:AGB94730.1}, Dfz2 GN {ECO:0000313|EMBL:AGB94730.1}, dFz2 {ECO:0000313|EMBL:AGB94730.1}, GN dfz2 {ECO:0000313|EMBL:AGB94730.1}, dfz2r GN {ECO:0000313|EMBL:AGB94730.1}, Dfz[[2]] {ECO:0000313|EMBL:AGB94730.1}, GN Dm Fz2 {ECO:0000313|EMBL:AGB94730.1}, Dmel\CG9739 GN {ECO:0000313|EMBL:AGB94730.1}, frz2 {ECO:0000313|EMBL:AGB94730.1}, GN fz-2 {ECO:0000313|EMBL:AGB94730.1}, FZ2 {ECO:0000313|EMBL:AGB94730.1}, GN Fz2 {ECO:0000313|EMBL:AGB94730.1}; GN ORFNames=CG9739 {ECO:0000313|EMBL:AGB94730.1, GN ECO:0000313|FlyBase:FBgn0016797}, Dmel_CG9739 GN {ECO:0000313|EMBL:AGB94730.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AGB94730.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AGB94730.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AGB94730.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AGB94730.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AGB94730.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [5] {ECO:0000313|EMBL:AGB94730.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AGB94730.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AGB94730.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:AGB94730.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo CC family. {ECO:0000256|SAAS:SAAS00874568}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014296; AGB94730.1; -; Genomic_DNA. DR RefSeq; NP_001262037.1; NM_001275108.2. DR UniGene; Dm.2524; -. DR ProteinModelPortal; M9PFW3; -. DR EnsemblMetazoa; FBtr0330195; FBpp0303228; FBgn0016797. DR GeneID; 40090; -. DR CTD; 40090; -. DR FlyBase; FBgn0016797; fz2. DR eggNOG; KOG3577; Eukaryota. DR eggNOG; ENOG410XRC8; LUCA. DR OrthoDB; EOG091G0N5M; -. DR GenomeRNAi; 40090; -. DR Proteomes; UP000000803; Chromosome 3L. DR Bgee; FBgn0016797; -. DR ExpressionAtlas; M9PFW3; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW. DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW. DR Gene3D; 1.10.2000.10; -; 1. DR InterPro; IPR015526; Frizzled/SFRP. DR InterPro; IPR000539; Frizzled/Smoothened_TM. DR InterPro; IPR020067; Frizzled_dom. DR InterPro; IPR036790; Frizzled_dom_sf. DR InterPro; IPR017981; GPCR_2-like. DR PANTHER; PTHR11309; PTHR11309; 1. DR Pfam; PF01534; Frizzled; 1. DR Pfam; PF01392; Fz; 1. DR PRINTS; PR00489; FRIZZLED. DR SMART; SM00063; FRI; 1. DR SMART; SM01330; Frizzled; 1. DR SUPFAM; SSF63501; SSF63501; 1. DR PROSITE; PS50038; FZ; 1. DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Developmental protein {ECO:0000256|SAAS:SAAS00022660}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00090, KW ECO:0000256|SAAS:SAAS00978052}; KW Membrane {ECO:0000256|SAAS:SAAS00874221, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00874335}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00874792, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00874766, KW ECO:0000256|SAM:Phobius}; KW Wnt signaling pathway {ECO:0000256|SAAS:SAAS00022642}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 806 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004101858. FT TRANSMEM 317 341 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 353 369 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 397 422 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 442 463 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 483 507 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 531 555 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 582 605 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 59 180 FZ. {ECO:0000259|PROSITE:PS50038}. FT DOMAIN 317 612 G_PROTEIN_RECEP_F2_4. FT {ECO:0000259|PROSITE:PS50261}. FT DISULFID 64 125 {ECO:0000256|PROSITE-ProRule:PRU00090}. FT DISULFID 72 118 {ECO:0000256|PROSITE-ProRule:PRU00090}. FT DISULFID 109 147 {ECO:0000256|PROSITE-ProRule:PRU00090}. FT DISULFID 136 177 {ECO:0000256|PROSITE-ProRule:PRU00090}. FT DISULFID 140 164 {ECO:0000256|PROSITE-ProRule:PRU00090}. SQ SEQUENCE 806 AA; 85496 MW; 14243863CF8C5E97 CRC64; MRHNRLKVLI LGLVLLLTSC RADGPLHSAD HGMGGMGMGG HGLDASPAPG YGVPVIPKDP NLRCEEITIP MCRGIGYNMT SFPNEMNHET QDEAGLEVHQ FWPLVEIKCS PDLKFFLCSM YTPICLEDYH KPLPVCRSVC ERARSGCAPI MQQYSFEWPE RMACEHLPLH GDPDNLCMEQ PSYTEAGSGG SSGGSGGSGS GSGSGGKRKQ GGSGSGGSGA GGSSGSTSTK PCRGRNSKNC QNPQGEKASG KECSCSCRSP LIFLGKEQLL QQQSQMPMMH HPHHWYMNLT VQRIAGVPNC GIPCKGPFFS NDEKDFAGLW IALWSGLCFC STLMTLTTFI IDTERFKYPE RPIVFLSACY FMVAVGYLSR NFLQNEEIAC DGLLLRESST GPHSCTLVFL LTYFFGMASS IWWVILSFTW FLAAGLKWGN EAITKHSQYF HLAAWLIPTV QSVAVLLLSA VDGDPILGIC YVGNLNPDHL KTFVLAPLFV YLVIGTTFLM AGFVSLFRIR SVIKQQGGVG AGVKADKLEK LMIRIGIFSV LYTVPATIVI GCYLYEAAYF EDWIKALACP CAQVKGPGKK PLYSVLMLKY FMALAVGITS GVWIWSGKTL ESWRRFWRRL LGAPDRTGAN QALIKQRPPI PHPYAGSGMG MPVGSAAGSL LATPYTQAGG ASVASTSHHH LHHHVLKQPA ASHVXHGESG GASTMGGGGG GGSTLGGGTL GHGTAMSSST VGMGPLPGTL MHGASGGGVG GGNPGNVYGN GNNGVGGQNT APGSVIDSRA VSVVVTLPGG PGAQHPGQAL SDYGPI //