ID M9PAZ7_DROME Unreviewed; 1336 AA. AC M9PAZ7; DT 12-AUG-2020, integrated into UniProtKB/TrEMBL. DT 12-AUG-2020, sequence version 1. DT 08-NOV-2023, entry version 14. DE SubName: Full=Roundabout 3, isoform C {ECO:0000313|EMBL:AGB92403.2}; GN Name=robo3 {ECO:0000313|EMBL:AGB92403.2, GN ECO:0000313|FlyBase:FBgn0041097}; GN Synonyms=CG14345 {ECO:0000313|EMBL:AGB92403.2}, CT17158 GN {ECO:0000313|EMBL:AGB92403.2}, Dmel\CG5423 GN {ECO:0000313|EMBL:AGB92403.2}, dRobo-3 {ECO:0000313|EMBL:AGB92403.2}, GN Robo {ECO:0000313|EMBL:AGB92403.2}, robo GN {ECO:0000313|EMBL:AGB92403.2}, Robo 3 {ECO:0000313|EMBL:AGB92403.2}, GN Robo-3 {ECO:0000313|EMBL:AGB92403.2}, robo-3 GN {ECO:0000313|EMBL:AGB92403.2}, ROBO3 {ECO:0000313|EMBL:AGB92403.2}, GN Robo3 {ECO:0000313|EMBL:AGB92403.2}; GN ORFNames=CG5423 {ECO:0000313|EMBL:AGB92403.2, GN ECO:0000313|FlyBase:FBgn0041097}, Dmel_CG5423 GN {ECO:0000313|EMBL:AGB92403.2}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AGB92403.2, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AGB92403.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AGB92403.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AGB92403.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AGB92403.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:AGB92403.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014134; AGB92403.2; -; Genomic_DNA. DR RefSeq; NP_001259866.1; NM_001272937.1. DR RefSeq; NP_608592.2; NM_134748.4. DR SMR; M9PAZ7; -. DR DNASU; 33314; -. DR EnsemblMetazoa; FBtr0479835; FBpp0428169; FBgn0041097. DR GeneID; 33314; -. DR AGR; FB:FBgn0041097; -. DR CTD; 64221; -. DR FlyBase; FBgn0041097; robo3. DR VEuPathDB; VectorBase:FBgn0041097; -. DR GeneTree; ENSGT00940000167162; -. DR OrthoDB; 5396194at2759; -. DR Proteomes; UP000000803; Chromosome 2L. DR Bgee; FBgn0041097; Expressed in central nervous system and 10 other tissues. DR ExpressionAtlas; M9PAZ7; baseline and differential. DR GO; GO:0031430; C:M band; IBA:GO_Central. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt. DR GO; GO:0030154; P:cell differentiation; IEA:UniProt. DR CDD; cd00063; FN3; 3. DR Gene3D; 2.60.40.10; Immunoglobulins; 8. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR013106; Ig_V-set. DR PANTHER; PTHR13817:SF172; LP22668P; 1. DR PANTHER; PTHR13817; TITIN; 1. DR Pfam; PF00041; fn3; 2. DR Pfam; PF07679; I-set; 3. DR Pfam; PF13927; Ig_3; 2. DR SMART; SM00060; FN3; 3. DR SMART; SM00409; IG; 5. DR SMART; SM00408; IGc2; 5. DR SMART; SM00406; IGv; 2. DR SUPFAM; SSF49265; Fibronectin type III; 2. DR SUPFAM; SSF48726; Immunoglobulin; 5. DR PROSITE; PS50853; FN3; 3. DR PROSITE; PS50835; IG_LIKE; 5. PE 4: Predicted; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..19 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 20..1336 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5026109351" FT TRANSMEM 868..890 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 23..115 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 121..207 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 215..301 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 306..402 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 411..494 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 521..616 FT /note="Fibronectin type-III" FT /evidence="ECO:0000259|PROSITE:PS50853" FT DOMAIN 645..738 FT /note="Fibronectin type-III" FT /evidence="ECO:0000259|PROSITE:PS50853" FT DOMAIN 743..842 FT /note="Fibronectin type-III" FT /evidence="ECO:0000259|PROSITE:PS50853" FT REGION 1060..1108 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1060..1086 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1336 AA; 144603 MW; BD3D05C379CC934E CRC64; MDLRFVFIVF LLKWTHAQGS HPPRIVEHPI DTTVPRHEPA TLNCKAEGSP TPTIQWYKDG VPLKILPGSH RITLPAGGLF FLKVVNSRRE TDAGIYWCEA KNELGVARSR NATLQVAVLR DEFRLEPQNT RIAQGDTALL ECAAPRGIPE PTVTWKKGGQ KLDLEGSKRV RIVDGGNLAI QDARQTDEGQ YQCIAKNPVG VRESSLATLK VHVKPYIIRG PHDQTVLEGA SVTFPCRVGG DPMPDVLWLR TASGGNMPLD RVSVLEDRSL RLERVTIADE GEYSCEADNV VGAITAMGTL TVYAPPKFIQ RPASKSVELG ADTSFECRAI GNPKPTIFWT IKNNSTLIFP GAPPLDRFHS LNTEEGHSIL TLTRFQRTDK DLVILCNAMN EVASITSRVQ LSLDSQEDRP PPIIISGPVN QTLPIKSLAT LQCKAIGLPS PTISWYRDGI PVQPSSKLNI TTSGDLIISD LDRQQDQGLY TCVASSRAGK STWSGFLRIE LPTNPNIKFY RAPEQTKCPS APGQPKILNA TASALTIVWP TSDKAGASSF LGYSVEMYCT NQSRTWIPIA SRLSEPIFTV ESLTQGAAYM FIVRAENSLG FSPPSPISEP ITAGKLVGVR DGSESTGTSQ LLLSDVETLL QANDVVELLE ANASDSTTAR LSWDIDSGQY IEGFYLYARE LHSSEYKMVT LLNKGQGLSS CTVPGLAKAS TYEFFLVPFY KSIVGKPSNS RRMRTLEDVP EAPPYGMEAI QFNRTSVFLK WLPPQPNRTR NGILTSYNVV VKGLDVHNTT RIFKNMTIDA AAPTLLLANL TTGVTYYIAV AAATRVGVGP FSKPAVLRID ARTQSLDTGY TRYPISRDIA DDFLTQTWFI VLLGSIIAII VFLLGALVLF KRYQFIKQTS LGSLHGNHAI GTVRKFPTLP LNGGGAVGAG GSNSTAAAGQ SGHGLWIDPT SGVWRQAAGG GNPGGVGSCT TKEQLPGYAQ ATAQQGQQPT LLPDYERLSP LNMPDYAEVA CSTFKSPTHG APPMGGGGGG QSASLYDSCG AYATTNVVAN VKLYQNRYAT KPNQSSGSNN NNHQGNDYQS TGMYSAPPSA HYGCLEPKQQ QQQQQPNLMT TSTASTAILT NSPAKVKKIN ITENKMDQLE GKSERTNPFN QQQQLLLASN ALKQGLGAYA NTTLAAQMAS GGGAGTLRRQ RQPKTLYKSE NNILGKSGLR QNTMNASVGA PSNGQMDFLT GGPPSEGGDF SGLGLCNSTN QLLNDWASSA SIAAPGDYHF GSKQPSKQHL YVKAKDGTWS AVSSDAYQSF KHQQQHHPFL AGSARTIWRR HSCAYMILDN SMDFVI //