ID M9PAZ7_DROME Unreviewed; 1336 AA. AC M9PAZ7; DT 12-AUG-2020, integrated into UniProtKB/TrEMBL. DT 12-AUG-2020, sequence version 1. DT 12-AUG-2020, entry version 1. DE SubName: Full=Roundabout 3, isoform C {ECO:0000313|EMBL:AGB92403.2}; GN Name=robo3 {ECO:0000313|EMBL:AGB92403.2, GN ECO:0000313|FlyBase:FBgn0041097}; GN Synonyms=CG14345 {ECO:0000313|EMBL:AGB92403.2}, CT17158 GN {ECO:0000313|EMBL:AGB92403.2}, Dmel\CG5423 GN {ECO:0000313|EMBL:AGB92403.2}, dRobo-3 {ECO:0000313|EMBL:AGB92403.2}, GN robo {ECO:0000313|EMBL:AGB92403.2}, Robo 3 GN {ECO:0000313|EMBL:AGB92403.2}, Robo-3 {ECO:0000313|EMBL:AGB92403.2}, GN robo-3 {ECO:0000313|EMBL:AGB92403.2}, ROBO3 GN {ECO:0000313|EMBL:AGB92403.2}, Robo3 {ECO:0000313|EMBL:AGB92403.2}; GN ORFNames=CG5423 {ECO:0000313|EMBL:AGB92403.2, GN ECO:0000313|FlyBase:FBgn0041097}, Dmel_CG5423 GN {ECO:0000313|EMBL:AGB92403.2}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AGB92403.2, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AGB92403.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AGB92403.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AGB92403.2, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., Harris N.L., RA Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., RA Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AGB92403.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AGB92403.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AGB92403.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AGB92403.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:AGB92403.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014134; AGB92403.2; -; Genomic_DNA. DR RefSeq; NP_001259866.1; NM_001272937.1. DR RefSeq; NP_608592.2; NM_134748.4. DR STRING; 7227.FBpp0077587; -. DR EnsemblMetazoa; FBtr0077921; FBpp0077587; FBgn0041097. DR EnsemblMetazoa; FBtr0335384; FBpp0307368; FBgn0041097. DR GeneID; 33314; -. DR KEGG; dme:Dmel_CG5423; -. DR UCSC; CG5423-RA; d. melanogaster. DR CTD; 64221; -. DR FlyBase; FBgn0041097; robo3. DR eggNOG; KOG4222; Eukaryota. DR GeneTree; ENSGT00940000167162; -. DR HOGENOM; CLU_003227_1_1_1; -. DR OMA; AAYMFIV; -. DR OrthoDB; 173520at2759; -. DR BioGRID-ORCS; 33314; 0 hits in 5 CRISPR screens. DR GenomeRNAi; 33314; -. DR Proteomes; UP000000803; Chromosome 2L. DR Bgee; FBgn0041097; Expressed in central nervous system and 17 other tissues. DR GO; GO:0030424; C:axon; IDA:FlyBase. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IDA:FlyBase. DR GO; GO:0030017; C:sarcomere; IBA:GO_Central. DR GO; GO:0007411; P:axon guidance; IMP:FlyBase. DR GO; GO:0007155; P:cell adhesion; IEA:InterPro. DR GO; GO:0048036; P:central complex development; IMP:FlyBase. DR GO; GO:0008406; P:gonad development; IMP:FlyBase. DR GO; GO:0016319; P:mushroom body development; IMP:FlyBase. DR GO; GO:0008038; P:neuron recognition; IMP:FlyBase. DR GO; GO:0016201; P:synaptic target inhibition; IMP:FlyBase. DR GO; GO:0007419; P:ventral cord development; IMP:FlyBase. DR CDD; cd00063; FN3; 3. DR Gene3D; 2.60.40.10; -; 8. DR InterPro; IPR043204; Basigin-like. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR013106; Ig_V-set. DR PANTHER; PTHR10075; PTHR10075; 1. DR Pfam; PF00041; fn3; 2. DR Pfam; PF07679; I-set; 3. DR SMART; SM00060; FN3; 3. DR SMART; SM00409; IG; 5. DR SMART; SM00408; IGc2; 5. DR SMART; SM00406; IGv; 2. DR SUPFAM; SSF48726; SSF48726; 5. DR SUPFAM; SSF49265; SSF49265; 2. DR PROSITE; PS50853; FN3; 3. DR PROSITE; PS50835; IG_LIKE; 5. PE 4: Predicted; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}. SQ SEQUENCE 1336 AA; 144603 MW; BD3D05C379CC934E CRC64; MDLRFVFIVF LLKWTHAQGS HPPRIVEHPI DTTVPRHEPA TLNCKAEGSP TPTIQWYKDG VPLKILPGSH RITLPAGGLF FLKVVNSRRE TDAGIYWCEA KNELGVARSR NATLQVAVLR DEFRLEPQNT RIAQGDTALL ECAAPRGIPE PTVTWKKGGQ KLDLEGSKRV RIVDGGNLAI QDARQTDEGQ YQCIAKNPVG VRESSLATLK VHVKPYIIRG PHDQTVLEGA SVTFPCRVGG DPMPDVLWLR TASGGNMPLD RVSVLEDRSL RLERVTIADE GEYSCEADNV VGAITAMGTL TVYAPPKFIQ RPASKSVELG ADTSFECRAI GNPKPTIFWT IKNNSTLIFP GAPPLDRFHS LNTEEGHSIL TLTRFQRTDK DLVILCNAMN EVASITSRVQ LSLDSQEDRP PPIIISGPVN QTLPIKSLAT LQCKAIGLPS PTISWYRDGI PVQPSSKLNI TTSGDLIISD LDRQQDQGLY TCVASSRAGK STWSGFLRIE LPTNPNIKFY RAPEQTKCPS APGQPKILNA TASALTIVWP TSDKAGASSF LGYSVEMYCT NQSRTWIPIA SRLSEPIFTV ESLTQGAAYM FIVRAENSLG FSPPSPISEP ITAGKLVGVR DGSESTGTSQ LLLSDVETLL QANDVVELLE ANASDSTTAR LSWDIDSGQY IEGFYLYARE LHSSEYKMVT LLNKGQGLSS CTVPGLAKAS TYEFFLVPFY KSIVGKPSNS RRMRTLEDVP EAPPYGMEAI QFNRTSVFLK WLPPQPNRTR NGILTSYNVV VKGLDVHNTT RIFKNMTIDA AAPTLLLANL TTGVTYYIAV AAATRVGVGP FSKPAVLRID ARTQSLDTGY TRYPISRDIA DDFLTQTWFI VLLGSIIAII VFLLGALVLF KRYQFIKQTS LGSLHGNHAI GTVRKFPTLP LNGGGAVGAG GSNSTAAAGQ SGHGLWIDPT SGVWRQAAGG GNPGGVGSCT TKEQLPGYAQ ATAQQGQQPT LLPDYERLSP LNMPDYAEVA CSTFKSPTHG APPMGGGGGG QSASLYDSCG AYATTNVVAN VKLYQNRYAT KPNQSSGSNN NNHQGNDYQS TGMYSAPPSA HYGCLEPKQQ QQQQQPNLMT TSTASTAILT NSPAKVKKIN ITENKMDQLE GKSERTNPFN QQQQLLLASN ALKQGLGAYA NTTLAAQMAS GGGAGTLRRQ RQPKTLYKSE NNILGKSGLR QNTMNASVGA PSNGQMDFLT GGPPSEGGDF SGLGLCNSTN QLLNDWASSA SIAAPGDYHF GSKQPSKQHL YVKAKDGTWS AVSSDAYQSF KHQQQHHPFL AGSARTIWRR HSCAYMILDN SMDFVI //