ID M9ND66_DROME Unreviewed; 1744 AA. AC M9ND66; DT 26-JUN-2013, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 1. DT 18-JAN-2017, entry version 30. DE SubName: Full=Formin homology 2 domain containing ortholog, isoform H {ECO:0000313|EMBL:AFH04355.1}; GN Name=Fhos {ECO:0000313|EMBL:AFH04355.1, GN ECO:0000313|FlyBase:FBgn0266084}; GN ORFNames=CG42610 {ECO:0000313|FlyBase:FBgn0266084}, Dmel_CG42610 GN {ECO:0000313|EMBL:AFH04355.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014296; AFH04355.1; -; Genomic_DNA. DR RefSeq; NP_001246684.1; NM_001259755.1. DR UniGene; Dm.1500; -. DR SMR; M9ND66; -. DR STRING; 7227.FBpp0306020; -. DR PaxDb; M9ND66; -. DR EnsemblMetazoa; FBtr0306632; FBpp0297587; FBgn0266084. DR GeneID; 39004; -. DR CTD; 39004; -. DR FlyBase; FBgn0266084; Fhos. DR eggNOG; KOG1925; Eukaryota. DR eggNOG; ENOG410XRBZ; LUCA. DR GeneTree; ENSGT00860000133772; -. DR OrthoDB; EOG091G039D; -. DR GenomeRNAi; 39004; -. DR Proteomes; UP000000803; Chromosome 3L. DR ExpressionAtlas; M9ND66; differential. DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase. DR GO; GO:0005634; C:nucleus; IDA:FlyBase. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:FlyBase. DR GO; GO:0003779; F:actin binding; ISS:FlyBase. DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase. DR GO; GO:0046716; P:muscle cell cellular homeostasis; IMP:FlyBase. DR GO; GO:0003012; P:muscle system process; IGI:FlyBase. DR GO; GO:0030335; P:positive regulation of cell migration; IMP:FlyBase. DR GO; GO:0051496; P:positive regulation of stress fiber assembly; IMP:FlyBase. DR GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IMP:FlyBase. DR GO; GO:0010623; P:programmed cell death involved in cell development; IMP:FlyBase. DR GO; GO:0035070; P:salivary gland histolysis; IMP:FlyBase. DR GO; GO:0019233; P:sensory perception of pain; IMP:FlyBase. DR GO; GO:0060439; P:trachea morphogenesis; IMP:FlyBase. DR GO; GO:0044319; P:wound healing, spreading of cells; IMP:FlyBase. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR014767; DAD_dom. DR InterPro; IPR015425; FH2_Formin. DR InterPro; IPR014768; GBD/FH3_dom. DR Pfam; PF02181; FH2; 1. DR SMART; SM00498; FH2; 1. DR SUPFAM; SSF48371; SSF48371; 1. DR PROSITE; PS51231; DAD; 1. DR PROSITE; PS51444; FH2; 1. DR PROSITE; PS51232; GBD_FH3; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}. FT DOMAIN 407 770 GBD/FH3 (Rho GTPase-binding/formin FT homology 3). {ECO:0000259|PROSITE: FT PS51232}. FT DOMAIN 1234 1625 FH2 (formin homology 2). FT {ECO:0000259|PROSITE:PS51444}. FT DOMAIN 1683 1715 DAD (diaphanous autoregulatory). FT {ECO:0000259|PROSITE:PS51231}. FT COILED 917 944 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 1744 AA; 196001 MW; 908F5330F6D4D5CA CRC64; MPSYRLRHID SGEEQAWWLR QDENGDDDDT LAEETLNTLD DDLQEPSKST WWSQDDQDSS SQVKLMPRSR ITPEKDAWWL QDEDEAAKSP IENGDLNNNN NSEPHVEVTL RLPSNGSQRS SKSSASKNGS NPKSGGANPW WLSGPARKMF NVQRVESGER AWWQEEAEEP PQEEKESEPP PVKPPTPPPR IIKHWESGER AWWLQDETES NQLPVQASSD DEEQPVLVVI NQQESRDEVD LRLAPPTLES QELSNSFNFD AHSERPPPLG QCASPVRCPS PYDNIPRSQL QEPPPPPTTT LTSLQPRFSP QTRRAGEKLF ISRHQNIDEL LGGACRPLSP LFYGNSNPAE SELTPLAGKN MFLLEEVTPD QVRIHDSTAQ LPVIQRMQRD VEWLDNGSNF YEPPEQRQHQ PPRRIDDAAI QVYKDGDYGA YLDLESSLAE QAEEIEGVNV SRKNSLVVRT QLNVRVQAII EKLLSAQGSD LRRALFSLKQ VFQEDKDLVH AFVALGGLNC LVRVGNCADQ NYQNYILRAL GQVMLYVDGM NGVMKHEPTM QWLYSLIASN YRSVVKTALK LLLVFVEYAE SNCYVLVSAI HAVDASQGTL PWSNIMRLLK DYDNADAELV IYATSLINKT LAGLNDQDSF YDESDLLEQQ GMETVIQRYM SKPGTDLDLL DQLQLYEAVL KFEDGESDGQ RLPQNSMRKT QRYRPGANTT ERRKSRRHST DNSPASLTKV LPTTVLRMTP TQATVDEDSS GSTNSTEFSG GLFNEKKPRD GAGVTPGLRR RRERAERHKS FLKEQQEAAA NGIFAALEQR EGLGQIVTAI PATIQTGDSP PQSLQHEVPP CNNISGITNI SNNNVSNLSC NDTPNNSLLV MSPSKQLLTG SHSISIINNS FDKASNNNQS EFLTKKNLFR ERNSTVINGI MKNIQQTDSA YKKYENEANR LNNYYSQSPK HQIHQPIQPT PEVLLSPKKT LNASGFDFTP APLSSTPVKC DVPPEPEPLS PVKKPAAAPP PPPPPPPPPP PPPGWWHAPI YNSPQARTLT STNPELLPHP VDPSDMESED QQLLLQLKRD HTVKDLTQKL SNLPMSPTQD SANRALVGDM SGLISKAKEG LAKSKSKGEI SRSSSVDQDV KKSEPKKSEN ELHWEELVRN MTRPLNLCDL DFTDLRDDDE KDVLAPRSLG AGIPPPPPPL GGAIAPPPMM PPSLAPPPMY GYGGSLTNSV NSLNGSINGE LVNGNNTIKK NKKTVKLFWK EVREDMIPQV VGKTIWDELP DANVDTQKLE HLFESRAKDL MTKKQQELNK SKEIIVLDHK RSNAINIAIT KLPPPRAIKT AILKMDATVV TREGIDKLLN MLPTDEERGK IQEAQLSNPE LPLGSAEQFL LTLASISELE ARLKLWAFRL DFDNSEKEIA EPLMDLKQGI EILRQNRTFR SILSTLLSVG IFLNGAPVKG FQIEYLAKVP EVKDTVHKHS LLHHLCHMVM ESSSDTSDLY SEIGPITRAS KADFTDLAHN LNQLEAECKA CWDRLKLIAK HDCPPPLKQK LVDFLADCAE RIIILQIVHR RVMNRYRKFL LWLGMPQHSV AESRPNEFCR TLSEFALEYR TTRERVQQQL EKKANHRERN KTRGKLIIDM AKFKTKDDVA DDELKKLLDT SSADQADGTL TWRRRRAEQL RSPITRQSEE QFTDGDDEIL ESLVKTATKA PGTRTTPRER KRTRHADRKS LRRTLKNGLT EEEKQHVAAL IQTY //