ID   M9ND66_DROME            Unreviewed;      1744 AA.
AC   M9ND66;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   08-JUN-2016, entry version 27.
DE   SubName: Full=Formin homology 2 domain containing ortholog, isoform H {ECO:0000313|EMBL:AFH04355.1};
GN   Name=Fhos {ECO:0000313|EMBL:AFH04355.1,
GN   ECO:0000313|FlyBase:FBgn0266084};
GN   ORFNames=CG42610 {ECO:0000313|FlyBase:FBgn0266084}, Dmel_CG42610
GN   {ECO:0000313|EMBL:AFH04355.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
RA   Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
RA   Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila
RT   melanogaster euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
RA   Ashburner M., Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin:
RT   a genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN   [5] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun
RT   assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [8] {ECO:0000313|EMBL:AFH04355.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
CC   -!- SIMILARITY: Contains FH2 (formin homology 2) domain.
CC       {ECO:0000256|SAAS:SAAS00502846}.
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DR   EMBL; AE014296; AFH04355.1; -; Genomic_DNA.
DR   RefSeq; NP_001246684.1; NM_001259755.1.
DR   UniGene; Dm.1500; -.
DR   STRING; 7227.FBpp0306020; -.
DR   PaxDb; M9ND66; -.
DR   EnsemblMetazoa; FBtr0306632; FBpp0297587; FBgn0266084.
DR   GeneID; 39004; -.
DR   CTD; 39004; -.
DR   FlyBase; FBgn0266084; Fhos.
DR   eggNOG; KOG1925; Eukaryota.
DR   eggNOG; ENOG410XRBZ; LUCA.
DR   GeneTree; ENSGT00810000125396; -.
DR   GenomeRNAi; 39004; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   ExpressionAtlas; M9ND66; differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR   GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:FlyBase.
DR   GO; GO:0003779; F:actin binding; ISS:FlyBase.
DR   GO; GO:0010623; P:developmental programmed cell death; IMP:FlyBase.
DR   GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
DR   GO; GO:0046716; P:muscle cell cellular homeostasis; IMP:FlyBase.
DR   GO; GO:0003012; P:muscle system process; IGI:FlyBase.
DR   GO; GO:0030335; P:positive regulation of cell migration; IMP:FlyBase.
DR   GO; GO:0051496; P:positive regulation of stress fiber assembly; IMP:FlyBase.
DR   GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IMP:FlyBase.
DR   GO; GO:0035070; P:salivary gland histolysis; IMP:FlyBase.
DR   GO; GO:0019233; P:sensory perception of pain; IMP:FlyBase.
DR   GO; GO:0060439; P:trachea morphogenesis; IMP:FlyBase.
DR   GO; GO:0044319; P:wound healing, spreading of cells; IMP:FlyBase.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014767; DAD_dom.
DR   InterPro; IPR015425; FH2_Formin.
DR   InterPro; IPR014768; GBD/FH3_dom.
DR   Pfam; PF02181; FH2; 1.
DR   SMART; SM00498; FH2; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS51231; DAD; 1.
DR   PROSITE; PS51444; FH2; 1.
DR   PROSITE; PS51232; GBD_FH3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000803};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT   DOMAIN      407    770       GBD/FH3 (Rho GTPase-binding/formin
FT                                homology 3). {ECO:0000259|PROSITE:
FT                                PS51232}.
FT   DOMAIN     1234   1625       FH2 (formin homology 2).
FT                                {ECO:0000259|PROSITE:PS51444}.
FT   DOMAIN     1683   1715       DAD (diaphanous autoregulatory).
FT                                {ECO:0000259|PROSITE:PS51231}.
FT   COILED      917    944       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1744 AA;  196001 MW;  908F5330F6D4D5CA CRC64;
     MPSYRLRHID SGEEQAWWLR QDENGDDDDT LAEETLNTLD DDLQEPSKST WWSQDDQDSS
     SQVKLMPRSR ITPEKDAWWL QDEDEAAKSP IENGDLNNNN NSEPHVEVTL RLPSNGSQRS
     SKSSASKNGS NPKSGGANPW WLSGPARKMF NVQRVESGER AWWQEEAEEP PQEEKESEPP
     PVKPPTPPPR IIKHWESGER AWWLQDETES NQLPVQASSD DEEQPVLVVI NQQESRDEVD
     LRLAPPTLES QELSNSFNFD AHSERPPPLG QCASPVRCPS PYDNIPRSQL QEPPPPPTTT
     LTSLQPRFSP QTRRAGEKLF ISRHQNIDEL LGGACRPLSP LFYGNSNPAE SELTPLAGKN
     MFLLEEVTPD QVRIHDSTAQ LPVIQRMQRD VEWLDNGSNF YEPPEQRQHQ PPRRIDDAAI
     QVYKDGDYGA YLDLESSLAE QAEEIEGVNV SRKNSLVVRT QLNVRVQAII EKLLSAQGSD
     LRRALFSLKQ VFQEDKDLVH AFVALGGLNC LVRVGNCADQ NYQNYILRAL GQVMLYVDGM
     NGVMKHEPTM QWLYSLIASN YRSVVKTALK LLLVFVEYAE SNCYVLVSAI HAVDASQGTL
     PWSNIMRLLK DYDNADAELV IYATSLINKT LAGLNDQDSF YDESDLLEQQ GMETVIQRYM
     SKPGTDLDLL DQLQLYEAVL KFEDGESDGQ RLPQNSMRKT QRYRPGANTT ERRKSRRHST
     DNSPASLTKV LPTTVLRMTP TQATVDEDSS GSTNSTEFSG GLFNEKKPRD GAGVTPGLRR
     RRERAERHKS FLKEQQEAAA NGIFAALEQR EGLGQIVTAI PATIQTGDSP PQSLQHEVPP
     CNNISGITNI SNNNVSNLSC NDTPNNSLLV MSPSKQLLTG SHSISIINNS FDKASNNNQS
     EFLTKKNLFR ERNSTVINGI MKNIQQTDSA YKKYENEANR LNNYYSQSPK HQIHQPIQPT
     PEVLLSPKKT LNASGFDFTP APLSSTPVKC DVPPEPEPLS PVKKPAAAPP PPPPPPPPPP
     PPPGWWHAPI YNSPQARTLT STNPELLPHP VDPSDMESED QQLLLQLKRD HTVKDLTQKL
     SNLPMSPTQD SANRALVGDM SGLISKAKEG LAKSKSKGEI SRSSSVDQDV KKSEPKKSEN
     ELHWEELVRN MTRPLNLCDL DFTDLRDDDE KDVLAPRSLG AGIPPPPPPL GGAIAPPPMM
     PPSLAPPPMY GYGGSLTNSV NSLNGSINGE LVNGNNTIKK NKKTVKLFWK EVREDMIPQV
     VGKTIWDELP DANVDTQKLE HLFESRAKDL MTKKQQELNK SKEIIVLDHK RSNAINIAIT
     KLPPPRAIKT AILKMDATVV TREGIDKLLN MLPTDEERGK IQEAQLSNPE LPLGSAEQFL
     LTLASISELE ARLKLWAFRL DFDNSEKEIA EPLMDLKQGI EILRQNRTFR SILSTLLSVG
     IFLNGAPVKG FQIEYLAKVP EVKDTVHKHS LLHHLCHMVM ESSSDTSDLY SEIGPITRAS
     KADFTDLAHN LNQLEAECKA CWDRLKLIAK HDCPPPLKQK LVDFLADCAE RIIILQIVHR
     RVMNRYRKFL LWLGMPQHSV AESRPNEFCR TLSEFALEYR TTRERVQQQL EKKANHRERN
     KTRGKLIIDM AKFKTKDDVA DDELKKLLDT SSADQADGTL TWRRRRAEQL RSPITRQSEE
     QFTDGDDEIL ESLVKTATKA PGTRTTPRER KRTRHADRKS LRRTLKNGLT EEEKQHVAAL
     IQTY
//