ID M9MS75_DROME Unreviewed; 2110 AA. AC M9MS75; DT 26-JUN-2013, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 1. DT 12-APR-2017, entry version 34. DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132}; GN Name=para {ECO:0000313|EMBL:ADV37697.1, GN ECO:0000313|FlyBase:FBgn0264255}; GN ORFNames=CG9907 {ECO:0000313|FlyBase:FBgn0264255}, Dmel_CG9907 GN {ECO:0000313|EMBL:ADV37697.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ADV37697.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:ADV37697.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:ADV37697.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:ADV37697.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:ADV37697.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:ADV37697.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:ADV37697.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:ADV37697.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:ADV37697.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability CC of excitable membranes. {ECO:0000256|RuleBase:RU361132}. CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU361132}. CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family. CC {ECO:0000256|RuleBase:RU361132}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448, CC ECO:0000256|RuleBase:RU361132}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014298; ADV37697.1; -; Genomic_DNA. DR RefSeq; NP_001188615.1; NM_001201686.1. DR UniGene; Dm.22809; -. DR STRING; 7227.FBpp0303597; -. DR PaxDb; M9MS75; -. DR EnsemblMetazoa; FBtr0303670; FBpp0292687; FBgn0264255. DR GeneID; 32619; -. DR CTD; 32619; -. DR FlyBase; FBgn0264255; para. DR eggNOG; KOG2301; Eukaryota. DR eggNOG; ENOG410XNP6; LUCA. DR GeneTree; ENSGT00830000128242; -. DR OrthoDB; EOG091G00FK; -. DR ChiTaRS; Prm; fly. DR GenomeRNAi; 32619; -. DR Proteomes; UP000000803; Chromosome X. DR ExpressionAtlas; M9MS75; differential. DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro. DR Gene3D; 1.10.238.10; -; 1. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR002048; EF_hand_dom. DR InterPro; IPR031649; GPHH_dom. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR001696; Na_channel_asu. DR InterPro; IPR010526; Na_trans_assoc. DR InterPro; IPR024583; Na_trans_cytopl. DR Pfam; PF16905; GPHH; 1. DR Pfam; PF00520; Ion_trans; 4. DR Pfam; PF06512; Na_trans_assoc; 1. DR Pfam; PF11933; Na_trans_cytopl; 1. DR PRINTS; PR00170; NACHANNEL. DR PROSITE; PS50222; EF_HAND_2; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Ion channel {ECO:0000256|RuleBase:RU361132}; KW Ion transport {ECO:0000256|RuleBase:RU361132}; KW Membrane {ECO:0000256|RuleBase:RU361132}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Sodium {ECO:0000256|RuleBase:RU361132}; KW Sodium channel {ECO:0000256|RuleBase:RU361132}; KW Sodium transport {ECO:0000256|RuleBase:RU361132}; KW Transmembrane {ECO:0000256|RuleBase:RU361132}; KW Transmembrane helix {ECO:0000256|RuleBase:RU361132}; KW Transport {ECO:0000256|RuleBase:RU361132}; KW Voltage-gated channel {ECO:0000256|RuleBase:RU361132, KW ECO:0000256|SAAS:SAAS00789202}. FT TRANSMEM 145 172 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 216 238 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 250 268 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 274 296 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 406 428 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 803 826 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 847 864 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 876 900 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 931 953 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1011 1032 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1320 1342 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1348 1374 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1395 1426 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1513 1539 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1602 1620 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1632 1651 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1663 1682 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1726 1749 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1812 1835 Helical. {ECO:0000256|RuleBase:RU361132}. FT DOMAIN 1856 1891 EF-hand. {ECO:0000259|PROSITE:PS50222}. FT COILED 432 482 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 2110 AA; 236817 MW; 4A1F05C08F8EAD0A CRC64; MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEV PQYGRKKKQK EIRYDDEDED EGPQPDPTLE QGVPIPVRLQ GSFPPELAST PLEDIDPYYS NVLTFVVVSK GKDIFRFSAS KAMWMLDPFN PIRRVAIYIL VHPLFSLFII TTILVNCILM IMPTTPTVES TEVIFTGIYT FESAVKVMAR GFILCPFTYL RDAWNWLDFV VIALAYVTMG IDLGNLAALR TFRVLRALKT VAIVPGLKTI VGAVIESVKN LRDVIILTMF SLSVFALMGL QIYMGVLTQK CIKKFPLDGS WGNLTDENWD YHNRNSSNWY SEDEGISFPL CGNISGAGQC DDDYVCLQGF GPNPNYGYTS FDSFGWAFLS AFRLMTQDFW EDLYQLVLRA AGPWHMLFFI VIIFLGSFYL VNLILAIVAM SYDELQKKAE EEEAAEEEAI REAEEAAAAK AAKLEERANA QAQAAADAAA AEEAALHPEM AKSPTYSCIS YELFVGGEKG NDDNNKEKMS IRSVEVESES VSVIQRQPAP TTAHQATKVR KVSTTSLSLP GSPFNIRRGS RSSHKYTIRN GRGRFGIPGS DRKPLVLSTY QDAQQHLPYA DDSNAVTPMS EENGAIIVPV YYGNLGSRHS SYTSHQSRIS YTSHGDLLGG MAVMGVSTMT KESKLRNRNT RNQSVGATNG GTTCLDTNHK LDHRDYEIGL ECTDEAGKIK HHDNPFIEPV QTQTVVDMKD VMVLNDIIEQ AAGRHSRASD RGEDDDEDGP TFKDKALEVI LKGIDVFCVW DCCWVWLKFQ EWVSLIVFDP FVELFITLCI VVNTMFMAMD HHDMNKEMER VLKSGNYFFT ATFAIEATMK LMAMSPKYYF QEGWNIFDFI IVALSLLELG LEGVQGLSVL RSFRLLRVFK LAKSWPTLNL LISIMGRTMG ALGNLTFVLC IIIFIFAVMG MQLFGKNYHD HKDRFPDGDL PRWNFTDFMH SFMIVFRVLC GEWIESMWDC MYVGDVSCIP FFLATVVIGN LVVLNLFLAL LLSNFGSSSL SAPTADNDTN KIAEAFNRIG RFKSWVKRNI ADCFKLIRNK LTNQISDQPS GKGVCRCISA EHGDNELELG HDEILADGLI KKGIKEQTQL EVAIGDGMEF TIHGDMKNNK PKKSKYLNNA TDDDTASINS YGSHKNRPFK DESHKGSAET MEGEEKRDAS KEDLGLDEEL DEEGECEEGP LDGDIIIHAH DEDILDEYPA DCCPDSYYKK FPILAGDDDS PFWQGWGNLR LKTFQLIENK YFETAVITMI LMSSLALALE DVHLPQRPIL QDILYYMDRI FTVIFFLEML IKWLALGFKV YFTNAWCWLD FVIVMVSLIN FVASLVGAGG IQAFKTMRTL RALRPLRAMS RMQGMRVVVN ALVQAIPSIF NVLLVCLIFW LIFAIMGVQL FAGKYFKCED MNGTKLSHEI IPNRNACESE NYTWVNSAMN FDHVGNAYLC LFQVATFKGW IQIMNDAIDS REVDKQPIRE TNIYMYLYFV FFIIFGSFFT LNLFIGVIID NFNEQKKKAG GSLEMFMTED QKKYYNAMKK MGSKKPLKAI PRPRWRPQAI VFEIVTDKKF DIIIMLFIGL NMFTMTLDRY DASDTYNAVL DYLNAIFVVI FSSECLLKIF ALRYHYFIEP WNLFDVVVVI LSILGLVLSD IIEKYFVSPT LLRVVRVAKV GRVLRLVKGA KGIRTLLFAL AMSLPALFNI CLLLFLVMFI FAIFGMSFFM HVKEKSGIND VYNFKTFGQS MILLFQMSTS AGWDGVLDAI INEEACDPPD NDKGYPGNCG SATVGITFLL SYLVISFLIV INMYIAVILE NYSQATEDVQ EGLTDDDYDM YYEIWQQFDP EGTQYIRYDQ LSEFLDVLEP PLQIHKPNKY KIISMDIPIC RGDLMYCVDI LDALTKDFFA RKGNPIEETG EIGEIAARPD TEGYEPVSST LWRQREEYCA RLIQHAWRKH KARGEGGGSF EPDTDHGDGG DPDAGDPAPD EATDGDAPAG GDGSVNGTAE GAADADESNV NSPGEDAAAA AAAAAAAAAA GTTTAGSPGA GSAGRQTAVL VESDGFVTKN GHKVVIHSRS PSITSRTADV //