ID M7CC40_CHEMY Unreviewed; 138 AA. AC M7CC40; DT 29-MAY-2013, integrated into UniProtKB/TrEMBL. DT 29-MAY-2013, sequence version 1. DT 29-MAY-2024, entry version 40. DE SubName: Full=Calcitonin {ECO:0000313|EMBL:EMP38282.1}; GN ORFNames=UY3_04491 {ECO:0000313|EMBL:EMP38282.1}; OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira; OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia. OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP38282.1, ECO:0000313|Proteomes:UP000031443}; RN [1] {ECO:0000313|Proteomes:UP000031443} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23624526; DOI=10.1038/ng.2615; RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C., RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y., RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J., RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S., RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.; RT "The draft genomes of soft-shell turtle and green sea turtle yield insights RT into the development and evolution of the turtle-specific body plan."; RL Nat. Genet. 45:701-706(2013). CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. CC -!- SIMILARITY: Belongs to the calcitonin family. CC {ECO:0000256|ARBA:ARBA00009222}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KB520249; EMP38282.1; -; Genomic_DNA. DR RefSeq; XP_007057158.1; XM_007057096.1. DR AlphaFoldDB; M7CC40; -. DR STRING; 8469.M7CC40; -. DR GeneID; 102937863; -. DR KEGG; cmy:102937863; -. DR CTD; 797; -. DR eggNOG; ENOG502RZI5; Eukaryota. DR OrthoDB; 4002581at2759; -. DR Proteomes; UP000031443; Unassembled WGS sequence. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0031716; F:calcitonin receptor binding; IEA:TreeGrafter. DR GO; GO:0005179; F:hormone activity; IEA:InterPro. DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:TreeGrafter. DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IEA:TreeGrafter. DR InterPro; IPR021118; Calcitonin. DR InterPro; IPR021117; Calcitonin-like. DR InterPro; IPR021116; Calcitonin/adrenomedullin. DR InterPro; IPR018360; Calcitonin_CS. DR InterPro; IPR001693; Calcitonin_peptide-like. DR PANTHER; PTHR10505:SF16; CALCITONIN; 1. DR PANTHER; PTHR10505; CALCITONIN-RELATED; 1. DR Pfam; PF00214; Calc_CGRP_IAPP; 1. DR PRINTS; PR00270; CALCITONINA. DR SMART; SM00113; CALCITONIN; 1. DR PROSITE; PS00258; CALCITONIN; 1. PE 3: Inferred from homology; KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685}; KW Disulfide bond {ECO:0000256|PIRSR:PIRSR621116-50}; KW Reference proteome {ECO:0000313|Proteomes:UP000031443}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}. FT SIGNAL 1..25 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 26..138 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5004080866" FT DOMAIN 80..117 FT /note="Calcitonin peptide-like" FT /evidence="ECO:0000259|SMART:SM00113" FT DISULFID 82..88 FT /evidence="ECO:0000256|PIRSR:PIRSR621116-50" SQ SEQUENCE 138 AA; 15457 MW; 8AAA3DEA4CF10AF3 CRC64; MVMLKISSFL AVYALVMCQM DRSQATPLRP GLESITDRVT LSDYEARRLL NALVKEFVQM TAEELEQATE ENSLDRPISK RCASLSTCVL GKLSQELHKL QTYPRTDVGA GTPGKKRNVL NDLENERYAN YGESLGNN //