ID   M7ANH5_CHEMY            Unreviewed;      1197 AA.
AC   M7ANH5;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   08-MAY-2019, entry version 45.
DE   RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase {ECO:0000256|PIRNR:PIRNR000956};
DE            EC=3.1.4.11 {ECO:0000256|PIRNR:PIRNR000956};
GN   ORFNames=UY3_16186 {ECO:0000313|EMBL:EMP26786.1};
OS   Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia;
OC   Chelonioidea; Cheloniidae; Chelonia.
OX   NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP26786.1, ECO:0000313|Proteomes:UP000031443};
RN   [1] {ECO:0000313|Proteomes:UP000031443}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z.,
RA   Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y.,
RA   Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M.,
RA   Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J.,
RA   Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G.,
RA   Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield
RT   insights into the development and evolution of the turtle-specific
RT   body plan.";
RL   Nat. Genet. 45:701-706(2013).
CC   -!- FUNCTION: The production of the second messenger molecules
CC       diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is
CC       mediated by activated phosphatidylinositol-specific phospholipase
CC       C enzymes. {ECO:0000256|PIRNR:PIRNR000956}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC         bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a
CC         1,2-diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815,
CC         ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000956,
CC         ECO:0000256|RuleBase:RU361133};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KB576442; EMP26786.1; -; Genomic_DNA.
DR   STRING; 8469.XP_007069464.1; -.
DR   Proteomes; UP000031443; Unassembled WGS sequence.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd13361; PH_PLC_beta; 1.
DR   Gene3D; 2.60.40.150; -; 1.
DR   Gene3D; 3.20.20.190; -; 2.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR001192; PI-PLC_fam.
DR   InterPro; IPR016280; PLC-beta.
DR   InterPro; IPR028403; PLC-beta2.
DR   InterPro; IPR014815; PLC-beta_C.
DR   InterPro; IPR009535; PLC-beta_CS.
DR   InterPro; IPR037862; PLC-beta_PH.
DR   InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR   InterPro; IPR015359; PLC_EF-hand-like.
DR   InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR   InterPro; IPR001711; PLipase_C_Pinositol-sp_Y.
DR   PANTHER; PTHR10336; PTHR10336; 1.
DR   PANTHER; PTHR10336:SF10; PTHR10336:SF10; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF06631; DUF1154; 1.
DR   Pfam; PF09279; EF-hand_like; 1.
DR   Pfam; PF17787; PH_14; 1.
DR   Pfam; PF00388; PI-PLC-X; 1.
DR   Pfam; PF00387; PI-PLC-Y; 1.
DR   Pfam; PF08703; PLC-beta_C; 1.
DR   PIRSF; PIRSF000956; PLC-beta; 1.
DR   PRINTS; PR00390; PHPHLIPASEC.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00148; PLCXc; 1.
DR   SMART; SM00149; PLCYc; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF51695; SSF51695; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50008; PIPLC_Y_DOMAIN; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000031443};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR000956,
KW   ECO:0000256|RuleBase:RU361133};
KW   Lipid degradation {ECO:0000256|PIRNR:PIRNR000956,
KW   ECO:0000256|RuleBase:RU361133};
KW   Lipid metabolism {ECO:0000256|PIRNR:PIRNR000956,
KW   ECO:0000256|RuleBase:RU361133};
KW   Transducer {ECO:0000256|PIRNR:PIRNR000956,
KW   ECO:0000256|SAAS:SAAS01019513}.
FT   DOMAIN      537    653       PI-PLC Y-box. {ECO:0000259|PROSITE:
FT                                PS50008}.
FT   DOMAIN      670    749       C2. {ECO:0000259|PROSITE:PS50004}.
FT   COILED      880    907       {ECO:0000256|SAM:Coils}.
FT   COILED     1063   1127       {ECO:0000256|SAM:Coils}.
FT   ACT_SITE    325    325       {ECO:0000256|PIRSR:PIRSR000956-1}.
FT   ACT_SITE    372    372       {ECO:0000256|PIRSR:PIRSR000956-1}.
SQ   SEQUENCE   1197 AA;  137129 MW;  33E299BA4930FFB2 CRC64;
     MFTSILTPPE VKEYLSKGER FIKWDDDTTN ASPVILRVDP KGFYLYWTYQ NKEMEFLDIT
     SIRDTRVGKF AKIPKSQKLR EVFNLDFPDN NFLLKTLTVV TGPDMVDLTF HNFVSYKESV
     GKSWAEDIMA IVRNPLTSNA SRYTFLEKIL VKLKMQLSAE GKIPVRNIFQ MFPADRKRVE
     AALHACHLPK GKNDAINPED FPEKVYKTFL MNLCPRPEID EIFTSLHSKA KPYMTKEHLA
     KFINKKQRDS RLNDMLFPPA KPEQVQGLIE KYEPSGINIQ RGQLSPEGMV WFLCGPENNI
     VSLDKVVLYQ DMTQPLSHYF INSSHNTYLT AGQFSGISSP EMYRQSLLSG CRCVELDCWK
     GRPPDEEPII THGFTMTTEI LFKDVIEAIA ESAFKTSLYP VILSFENHVD SPRQQAKMAE
     YCRTIFGDTL LTEPLEKYPL KPGVPLPSPQ DLLGKILIKN KKKQSASEER QDSLKKERNE
     TTDQPFTVDG IVWAGEVTEE DPEEEEEESG NLDEEQIKKM QSDEGTAGLE VTAYEEMSSL
     VNYIQPIKFD SFDISTEQNR SYVISSFTEM KAYDLLTKSP VQFVEYNKRQ MSRIYPKGTR
     MDSSNYLPQM FWNVGCQMVA LNFQTMDVPM QQNMALFEFN GQSGYLLKHE FMRRPDKQFD
     PFSVDRIDVI LSGQFLSERS VKSYVEVELF GLPGDPKRKY RTKLTSSANS LNPVWKEEAF
     VFEKIMMPEL ASLRIVALEE GGKFIGQRII PIIAVHSGYH HVCLRSESNM PLTMPSLFVY
     LEMKDYVPDT WADLTVALSN PIKFFNNQDK RSVKLKQGSA EKKLTAAQTN GIPNSTRTFS
     FHSSNGPAGA MALGKEETIK EVAKEVAELQ TASLEELQKM KLFMKLLKKQ EKELKELERK
     GSKRREELLQ RYSALFSELV TQCGRKKIAC PRKTQKKKSS LTVEEVIAGG NPAEMAENAD
     SRVLELKEKL EMHLMQLWEE QHDGIRKKKE QHATEQISRL IEVAREKQAA ELKALKESSE
     SDTKEIKKKL EAKRLDRIQA MTKSTIDKTA QERLKREINN SHIQEVVQMI KLVTEKMAKY
     QEKLEEKQAD CLEKIKEKES QLQKEALAEY EEKVKTLSME VQDLARNCVK ICFPLEANIK
     KEEALNASSE GKQGSKDQPE GKIPGAEISW LETSMAETSI AQTQKVELSE QNEESRL
//