ID M7AKN2_CHEMY Unreviewed; 1526 AA. AC M7AKN2; DT 29-MAY-2013, integrated into UniProtKB/TrEMBL. DT 29-MAY-2013, sequence version 1. DT 10-APR-2019, entry version 36. DE SubName: Full=Non-receptor tyrosine-protein kinase TYK2 {ECO:0000313|EMBL:EMP24984.1}; GN ORFNames=UY3_17936 {ECO:0000313|EMBL:EMP24984.1}; OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia; OC Chelonioidea; Cheloniidae; Chelonia. OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP24984.1}; RN [1] {ECO:0000313|EMBL:EMP24984.1} RP NUCLEOTIDE SEQUENCE. RA Zhang G., Huang Z., Wang Z.; RT "Development and evolution of a turtle-specific body plan assessed by RT genome-wide analyses."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L- CC tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, CC Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; CC EC=2.7.10.2; Evidence={ECO:0000256|SAAS:SAAS01115681}; CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein CC kinase family. {ECO:0000256|SAAS:SAAS00941529}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KB595547; EMP24984.1; -; Genomic_DNA. DR STRING; 8469.XP_007071282.1; -. DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro. DR GO; GO:0016020; C:membrane; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC. DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR Gene3D; 1.20.58.610; -; 1. DR Gene3D; 3.30.505.10; -; 1. DR InterPro; IPR019749; Band_41_domain. DR InterPro; IPR013873; Cdc37_C. DR InterPro; IPR013874; Cdc37_Hsp90-bd. DR InterPro; IPR038189; Cdc37_Hsp90-bd_sf. DR InterPro; IPR013855; Cdc37_N_dom. DR InterPro; IPR035963; FERM_2. DR InterPro; IPR000299; FERM_domain. DR InterPro; IPR041155; FERM_F1. DR InterPro; IPR041046; FERM_F2. DR InterPro; IPR041381; Jak1_PHL_dom. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR000980; SH2. DR InterPro; IPR036860; SH2_dom_sf. DR InterPro; IPR008266; Tyr_kinase_AS. DR InterPro; IPR020635; Tyr_kinase_cat_dom. DR InterPro; IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2. DR InterPro; IPR016045; Tyr_kinase_non-rcpt_TYK2_N. DR Pfam; PF08564; CDC37_C; 1. DR Pfam; PF08565; CDC37_M; 1. DR Pfam; PF18379; FERM_F1; 1. DR Pfam; PF18377; FERM_F2; 1. DR Pfam; PF17887; Jak1_Phl; 1. DR Pfam; PF07714; Pkinase_Tyr; 2. DR PRINTS; PR01823; JANUSKINASE. DR PRINTS; PR00109; TYRKINASE. DR PRINTS; PR01827; YKINASETYK2. DR SMART; SM00295; B41; 1. DR SMART; SM01069; CDC37_C; 1. DR SMART; SM01070; CDC37_M; 1. DR SMART; SM01071; CDC37_N; 1. DR SMART; SM00252; SH2; 1. DR SMART; SM00219; TyrKc; 2. DR SUPFAM; SSF47031; SSF47031; 1. DR SUPFAM; SSF55550; SSF55550; 1. DR SUPFAM; SSF56112; SSF56112; 2. DR PROSITE; PS50057; FERM_3; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|SAAS:SAAS00990534}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Kinase {ECO:0000256|SAAS:SAAS00987901, ECO:0000313|EMBL:EMP24984.1}; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS00987259}; KW Receptor {ECO:0000313|EMBL:EMP24984.1}; KW Transferase {ECO:0000256|SAAS:SAAS00989498}; KW Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00897698}. FT DOMAIN 345 748 FERM. {ECO:0000259|PROSITE:PS50057}. FT DOMAIN 911 1193 Protein kinase. {ECO:0000259|PROSITE: FT PS50011}. FT DOMAIN 1215 1515 Protein kinase. {ECO:0000259|PROSITE: FT PS50011}. FT COILED 1 35 {ECO:0000256|SAM:Coils}. FT COILED 37 71 {ECO:0000256|SAM:Coils}. FT COILED 226 246 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 1526 AA; 174567 MW; ED7859772CFA7174 CRC64; MEQFQKEKEE LDKGCRECKR KLAECQKKMK ELEVADAVSG KGELQRLQAE AQQLRKEEKS WEKKIEELRK KEKNMPWNVD TLSKDGFSKS VFNVKPEEDD ESEEQKEKKH KTFVEKYEKQ IKHFGMLRRW DDSQKYLSDN PHLVCEETAN YLVIWCIDLE VEEKHALMEQ VAHQTIVMQF ILELAKSLKV DPRACFRQFF TKIKTADQQY MEGFTDELEA FKERVRGRAK VRIEKAMKEY EEEERQKRLG PGGLDPVEVY ESLPAELQKC FDSKDVQMLQ DAISKMEPAE AKYHMQRCID SGLWVPNAKT AEGAEKGGIG EMSLCQCAVK HSESDVEGCC FSVGGGLKVY LHWNGEEEER CQTYTQGVLS AEEICINIAQ KIGITPLCYS LFALCDVQTR VWLPPNHVFE ISKDTNLNLF FRMRYYFRNW HGMSDKEPAV YRNVPRQSDV PEDKLQGGAL LDKSSFEYLF EQGKYEFIND VVSLKDLQSE QEIHRFKNES LGMAVLHLSH MALKRGVSLE EVAKKTSFKG CIPRSFCRQI QQNNYLTRFR MRNVFRKFVQ RFQRHTVSAG KLTEQDVMYK YLATLENLAP RFGSELFPVL SLETASEGEK VLLYVNGGHT PLEGGCVSSP RDRPATHEVL VTGTDGIQWR TVPVESAESH PHRSYFGRKT RAKELDPKGL CQPVERSEAK WVRFCDFQEI THIVLKDCKV SINRQDNKCL ELVLPSHETA LSLVSLVDGY FRLTADSSHY LCHEVAPPRL VMSVLNGIHG PMQEEFVFAK LKREEQDGLY VIRWSVLNFN RLILSVVKRD HGQGSGTQTT PTYRQFRIQK RGVSFVLEGW EREFSTVREL MDVLKGCTLK SGEESFAVRR CCPPKPGEIS DLIIARKVKD STRQILNLTQ LSFHQIRKNE ITQRAHLGQG TRTNIYEGVL HVCGGAGGDD EAEYFSTEQN NNSREMHVVL KVLDPSHRDI ALAFFETASL MSQVSHIHLA FVHGVCVRGS ENIMVEEYVE HGPLDVLLRK EKGRVTVGWK VTVAKQLASA LSYLEDKNLV HGNVCAKNIL LARKGLEDGL LPFVKLSDPG VSFTVLSREE RVDRIPWIAP ECVQDVSSLS TAADKWSFGT TLLEICFDAD VPLKERTPSE KERFYEKKHR LPEPSCKELA ALISQCLTYA PSERPSFRTI LRDLTQLQPH NLVDVTSVSP DFPVSDPTVF QKRYLKKIRE LGEGHFGKVS LYCYDPTNDG TGEMVAVKSL KSGCSQQLLT SWKREIEILK TLYHENIVKY KGCCSEQGEK IVQLIMEYVP LGSLRDYLPK HNVSLAHILL FAQQICEGMA YLHSLHYIHR DLAARNVLLE NENVVKIGDF GLAKAIPEGH EYYRVCEDGD SPVFWYAMEC LKECKFYYAS DVWSFGVTLY ELLTRCDSSQ SPPVKFIEMI GVTQGQMTVL RLIELLDRGK RLPSPKDCPC EGEHHNCTGA GPGQALDERK YSIYCLMRNC WESKASFRPA FKNLVPILKS FHEKYKAQAP SVFSVC //