ID M4HNV6_9SAUR Unreviewed; 49 AA. AC M4HNV6; DT 29-MAY-2013, integrated into UniProtKB/TrEMBL. DT 29-MAY-2013, sequence version 1. DT 27-NOV-2024, entry version 23. DE RecName: Full=Reelin {ECO:0000256|ARBA:ARBA00023900}; DE Flags: Fragment; GN Name=reln {ECO:0000313|EMBL:AFR42958.1}; OS Trachemys decussata. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira; OC Testudinoidea; Emydidae; Trachemys. OX NCBI_TaxID=365624 {ECO:0000313|EMBL:AFR42958.1}; RN [1] {ECO:0000313|EMBL:AFR42958.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=JFP577 {ECO:0000313|EMBL:AFR42956.1}, JFP578 RC {ECO:0000313|EMBL:AFR42958.1}, JFP579 {ECO:0000313|EMBL:AFR42960.1}, RC JFP580 {ECO:0000313|EMBL:AFR42962.1}, JFP581 RC {ECO:0000313|EMBL:AFR42964.1}, JFP582 {ECO:0000313|EMBL:AFR42966.1}, RC JFP628 {ECO:0000313|EMBL:AFR42984.1}, and JFP632 RC {ECO:0000313|EMBL:AFR42987.1}; RX PubMed=23353072; DOI=10.1016/j.ympev.2013.01.004; RA Parham J.F., Papenfuss T.J., Dijk P.P., Wilson B.S., Marte C., RA Schettino L.R., Brian Simison W.; RT "Genetic introgression and hybridization in Antillean freshwater turtles RT (Trachemys) revealed by coalescent analyses of mitochondrial and cloned RT nuclear markers."; RL Mol. Phylogenet. Evol. 67:176-187(2013). CC -!- FUNCTION: Extracellular matrix serine protease secreted by pioneer CC neurons that plays a role in layering of neurons in the cerebral cortex CC and cerebellum by coordinating cell positioning during CC neurodevelopment. Regulates microtubule function in neurons and CC neuronal migration. Binding to the extracellular domains of lipoprotein CC receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of CC DAB1 and modulation of TAU phosphorylation. Affects migration of CC sympathetic preganglionic neurons in the spinal cord, where it seems to CC act as a barrier to neuronal migration. Enzymatic activity is important CC for the modulation of cell adhesion. {ECO:0000256|ARBA:ARBA00046064}. CC -!- SUBUNIT: Oligomer of disulfide-linked homodimers. CC {ECO:0000256|ARBA:ARBA00044961}. CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular CC matrix {ECO:0000256|ARBA:ARBA00004498}. CC -!- SIMILARITY: Belongs to the reelin family. CC {ECO:0000256|ARBA:ARBA00023773}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JN707437; AFR42956.1; -; Genomic_DNA. DR EMBL; JN707438; AFR42957.1; -; Genomic_DNA. DR EMBL; JN707439; AFR42958.1; -; Genomic_DNA. DR EMBL; JN707440; AFR42959.1; -; Genomic_DNA. DR EMBL; JN707441; AFR42960.1; -; Genomic_DNA. DR EMBL; JN707442; AFR42961.1; -; Genomic_DNA. DR EMBL; JN707443; AFR42962.1; -; Genomic_DNA. DR EMBL; JN707444; AFR42963.1; -; Genomic_DNA. DR EMBL; JN707445; AFR42964.1; -; Genomic_DNA. DR EMBL; JN707446; AFR42965.1; -; Genomic_DNA. DR EMBL; JN707447; AFR42966.1; -; Genomic_DNA. DR EMBL; JN707448; AFR42967.1; -; Genomic_DNA. DR EMBL; JN707465; AFR42984.1; -; Genomic_DNA. DR EMBL; JN707466; AFR42985.1; -; Genomic_DNA. DR EMBL; JN707468; AFR42987.1; -; Genomic_DNA. DR EMBL; JN707469; AFR42988.1; -; Genomic_DNA. DR AlphaFoldDB; M4HNV6; -. DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:TreeGrafter. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0043005; C:neuron projection; IEA:TreeGrafter. DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. DR GO; GO:0070325; F:lipoprotein particle receptor binding; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0007417; P:central nervous system development; IEA:InterPro. DR GO; GO:0001764; P:neuron migration; IEA:InterPro. DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1. DR InterPro; IPR034968; Reelin. DR InterPro; IPR049419; Reelin_subrepeat-B. DR PANTHER; PTHR11841; REELIN; 1. DR PANTHER; PTHR11841:SF1; REELIN; 1. DR Pfam; PF21471; Reelin_subrepeat-B; 1. PE 3: Inferred from homology; KW Calcium {ECO:0000256|ARBA:ARBA00022837}; KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889}; KW Developmental protein {ECO:0000256|ARBA:ARBA00022473}; KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Protease {ECO:0000256|ARBA:ARBA00022670}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; KW Serine protease {ECO:0000256|ARBA:ARBA00022825}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}. FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AFR42958.1" FT NON_TER 49 FT /evidence="ECO:0000313|EMBL:AFR42958.1" SQ SEQUENCE 49 AA; 5448 MW; 91552172C0C7B9C4 CRC64; YAHGDSLYFN GCQIRQAITK PLDLTRASKI MFVLQIGSIS QTESCNTNL //