ID M4HNV6_9SAUR Unreviewed; 49 AA. AC M4HNV6; DT 29-MAY-2013, integrated into UniProtKB/TrEMBL. DT 29-MAY-2013, sequence version 1. DT 03-MAY-2023, entry version 18. DE RecName: Full=Reelin {ECO:0000256|ARBA:ARBA00023900}; DE Flags: Fragment; GN Name=reln {ECO:0000313|EMBL:AFR42958.1}; OS Trachemys decussata. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira; OC Testudinoidea; Emydidae; Trachemys. OX NCBI_TaxID=365624 {ECO:0000313|EMBL:AFR42958.1}; RN [1] {ECO:0000313|EMBL:AFR42958.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=JFP577 {ECO:0000313|EMBL:AFR42956.1}, JFP578 RC {ECO:0000313|EMBL:AFR42958.1}, JFP579 {ECO:0000313|EMBL:AFR42960.1}, RC JFP580 {ECO:0000313|EMBL:AFR42962.1}, JFP581 RC {ECO:0000313|EMBL:AFR42964.1}, JFP582 {ECO:0000313|EMBL:AFR42966.1}, RC JFP628 {ECO:0000313|EMBL:AFR42984.1}, and JFP632 RC {ECO:0000313|EMBL:AFR42987.1}; RX PubMed=23353072; DOI=10.1016/j.ympev.2013.01.004; RA Parham J.F., Papenfuss T.J., Dijk P.P., Wilson B.S., Marte C., RA Schettino L.R., Brian Simison W.; RT "Genetic introgression and hybridization in Antillean freshwater turtles RT (Trachemys) revealed by coalescent analyses of mitochondrial and cloned RT nuclear markers."; RL Mol. Phylogenet. Evol. 67:176-187(2013). CC -!- FUNCTION: Extracellular matrix serine protease that plays a role in CC layering of neurons in the cerebral cortex and cerebellum. Regulates CC microtubule function in neurons and neuronal migration. Affects CC migration of sympathetic preganglionic neurons in the spinal cord, CC where it seems to act as a barrier to neuronal migration. Enzymatic CC activity is important for the modulation of cell adhesion. Binding to CC the extracellular domains of lipoprotein receptors VLDLR and CC LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of CC TAU phosphorylation. {ECO:0000256|ARBA:ARBA00024808}. CC -!- SUBUNIT: Oligomer of disulfide-linked homodimers. Binds to the CC ectodomains of VLDLR and LRP8/APOER2. {ECO:0000256|ARBA:ARBA00025845}. CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular CC matrix {ECO:0000256|ARBA:ARBA00004498}. CC -!- SIMILARITY: Belongs to the reelin family. CC {ECO:0000256|ARBA:ARBA00023773}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JN707437; AFR42956.1; -; Genomic_DNA. DR EMBL; JN707438; AFR42957.1; -; Genomic_DNA. DR EMBL; JN707439; AFR42958.1; -; Genomic_DNA. DR EMBL; JN707440; AFR42959.1; -; Genomic_DNA. DR EMBL; JN707441; AFR42960.1; -; Genomic_DNA. DR EMBL; JN707442; AFR42961.1; -; Genomic_DNA. DR EMBL; JN707443; AFR42962.1; -; Genomic_DNA. DR EMBL; JN707444; AFR42963.1; -; Genomic_DNA. DR EMBL; JN707445; AFR42964.1; -; Genomic_DNA. DR EMBL; JN707446; AFR42965.1; -; Genomic_DNA. DR EMBL; JN707447; AFR42966.1; -; Genomic_DNA. DR EMBL; JN707448; AFR42967.1; -; Genomic_DNA. DR EMBL; JN707465; AFR42984.1; -; Genomic_DNA. DR EMBL; JN707466; AFR42985.1; -; Genomic_DNA. DR EMBL; JN707468; AFR42987.1; -; Genomic_DNA. DR EMBL; JN707469; AFR42988.1; -; Genomic_DNA. DR AlphaFoldDB; M4HNV6; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW. DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. DR GO; GO:0070325; F:lipoprotein particle receptor binding; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0007417; P:central nervous system development; IEA:InterPro. DR GO; GO:0001764; P:neuron migration; IEA:InterPro. DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1. DR InterPro; IPR034968; Reelin. DR PANTHER; PTHR11841; REELIN; 1. DR PANTHER; PTHR11841:SF1; REELIN; 1. PE 3: Inferred from homology; KW Calcium {ECO:0000256|ARBA:ARBA00022837}; KW Developmental protein {ECO:0000256|ARBA:ARBA00022473}; KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}. FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AFR42958.1" FT NON_TER 49 FT /evidence="ECO:0000313|EMBL:AFR42958.1" SQ SEQUENCE 49 AA; 5448 MW; 91552172C0C7B9C4 CRC64; YAHGDSLYFN GCQIRQAITK PLDLTRASKI MFVLQIGSIS QTESCNTNL //