ID M3WK78_FELCA Unreviewed; 295 AA. AC M3WK78; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 12-SEP-2018, entry version 44. DE SubName: Full=Mitogen-activated protein kinase 3 {ECO:0000313|Ensembl:ENSFCAP00000013148}; GN Name=MAPK3 {ECO:0000313|Ensembl:ENSFCAP00000013148}; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000013148, ECO:0000313|Proteomes:UP000011712}; RN [1] {ECO:0000313|Ensembl:ENSFCAP00000013148, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013148, RC ECO:0000313|Proteomes:UP000011712}; RX PubMed=17975172; DOI=10.1101/gr.6380007; RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., RA Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., RA Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N., RA Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.; RT "Initial sequence and comparative analysis of the cat genome."; RL Genome Res. 17:1675-1689(2007). RN [2] {ECO:0000313|Ensembl:ENSFCAP00000013148} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013148}; RA Hillier L.W., Warren W., Obrien S., Wilson R.K.; RT "Sequence assembly of the Felis catus genome version 6.2."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSFCAP00000013148} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013148}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AANG03037807; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03037808; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03037809; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03037810; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9685.ENSFCAP00000013148; -. DR Ensembl; ENSFCAT00000014177; ENSFCAP00000013148; ENSFCAG00000014173. DR eggNOG; KOG0660; Eukaryota. DR eggNOG; ENOG410XNY0; LUCA. DR GeneTree; ENSGT00910000144035; -. DR InParanoid; M3WK78; -. DR OMA; AYGMVSS; -. DR OrthoDB; EOG091G08QL; -. DR Proteomes; UP000011712; Chromosome E3. DR Bgee; ENSFCAG00000014173; Expressed in 3 organ(s), highest expression level in prefrontal cortex. DR GO; GO:0005901; C:caveola; IBA:GO_Central. DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central. DR GO; GO:0005829; C:cytosol; IBA:GO_Central. DR GO; GO:0005769; C:early endosome; IBA:GO_Central. DR GO; GO:0005925; C:focal adhesion; IBA:GO_Central. DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central. DR GO; GO:0005770; C:late endosome; IBA:GO_Central. DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0004707; F:MAP kinase activity; IBA:GO_Central. DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central. DR GO; GO:0071310; P:cellular response to organic substance; IBA:GO_Central. DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR Pfam; PF00069; Pkinase; 1. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF56112; SSF56112; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000011712}; KW Reference proteome {ECO:0000313|Proteomes:UP000011712}. FT DOMAIN 1 246 Protein kinase. {ECO:0000259|PROSITE: FT PS50011}. SQ SEQUENCE 295 AA; 34115 MW; C25659F205AC1D93 CRC64; GPLSSAYDHV RKTRVAIKKI SPFEHQTYCQ RTLREIQILL RFRHENVIGI RDILRAPTLE AMRDVYIVQD LMETDLYKLL KSQQLSNDHI CYFLYQILRA NVLHRDLKPS NLLINTTCDL KICDFGLARI ADPEHDHTGF LTEYVATRWY RAPEIMLNSK VKGRTLKKAP ALPTGILGSP SQEDLNCIIN MKARNYLQSL PSKTKVAWAK LFPKSDAKAL DLLDRMLTFN PNKRITVEEA LAHPYLEQYY DPTDEPVAEE PFTFDMELDD LPKERLKELI FQETARFQPG ALEAP //