ID M3WK78_FELCA Unreviewed; 295 AA. AC M3WK78; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 2. DT 28-FEB-2018, entry version 41. DE RecName: Full=Mitogen-activated protein kinase {ECO:0000256|SAAS:SAAS00652812}; DE EC=2.7.11.24 {ECO:0000256|SAAS:SAAS00652812}; GN Name=MAPK3 {ECO:0000313|Ensembl:ENSFCAP00000013148}; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000013148, ECO:0000313|Proteomes:UP000011712}; RN [1] {ECO:0000313|Ensembl:ENSFCAP00000013148, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013148, RC ECO:0000313|Proteomes:UP000011712}; RX PubMed=17975172; DOI=10.1101/gr.6380007; RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., RA Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., RA Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N., RA Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.; RT "Initial sequence and comparative analysis of the cat genome."; RL Genome Res. 17:1675-1689(2007). RN [2] {ECO:0000313|Ensembl:ENSFCAP00000013148} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013148}; RA Hillier L.W., Warren W., Obrien S., Wilson R.K.; RT "Sequence assembly of the Felis catus genome version 6.2."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSFCAP00000013148} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013148}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. CC {ECO:0000256|SAAS:SAAS00652814}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000013148}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AANG03037807; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03037808; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03037809; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG03037810; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9685.ENSFCAP00000013148; -. DR Ensembl; ENSFCAT00000014177; ENSFCAP00000013148; ENSFCAG00000014173. DR eggNOG; KOG0660; Eukaryota. DR eggNOG; ENOG410XNY0; LUCA. DR GeneTree; ENSGT00910000144035; -. DR InParanoid; M3WK78; -. DR OMA; AYGMVSS; -. DR OrthoDB; EOG091G08QL; -. DR Proteomes; UP000011712; Chromosome E3. DR Bgee; ENSFCAG00000014173; -. DR GO; GO:0005901; C:caveola; IBA:GO_Central. DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central. DR GO; GO:0005829; C:cytosol; IBA:GO_Central. DR GO; GO:0005769; C:early endosome; IBA:GO_Central. DR GO; GO:0005925; C:focal adhesion; IBA:GO_Central. DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central. DR GO; GO:0005770; C:late endosome; IBA:GO_Central. DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central. DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0031143; C:pseudopodium; IEA:Ensembl. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl. DR GO; GO:0004707; F:MAP kinase activity; IBA:GO_Central. DR GO; GO:0004708; F:MAP kinase kinase activity; IEA:Ensembl. DR GO; GO:0019902; F:phosphatase binding; IEA:Ensembl. DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl. DR GO; GO:0060020; P:Bergmann glial cell differentiation; IEA:Ensembl. DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl. DR GO; GO:0061308; P:cardiac neural crest cell development involved in heart development; IEA:Ensembl. DR GO; GO:0051216; P:cartilage development; IEA:Ensembl. DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central. DR GO; GO:0034198; P:cellular response to amino acid starvation; IEA:Ensembl. DR GO; GO:0071276; P:cellular response to cadmium ion; IEA:Ensembl. DR GO; GO:1903351; P:cellular response to dopamine; IEA:Ensembl. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0071310; P:cellular response to organic substance; IBA:GO_Central. DR GO; GO:0034614; P:cellular response to reactive oxygen species; IEA:Ensembl. DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl. DR GO; GO:0006975; P:DNA damage induced protein phosphorylation; IEA:Ensembl. DR GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl. DR GO; GO:0060324; P:face development; IEA:Ensembl. DR GO; GO:0070498; P:interleukin-1-mediated signaling pathway; IEA:Ensembl. DR GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl. DR GO; GO:0060425; P:lung morphogenesis; IEA:Ensembl. DR GO; GO:2000657; P:negative regulation of apolipoprotein binding; IEA:Ensembl. DR GO; GO:0042473; P:outer ear morphogenesis; IEA:Ensembl. DR GO; GO:0038083; P:peptidyl-tyrosine autophosphorylation; IEA:Ensembl. DR GO; GO:0031281; P:positive regulation of cyclase activity; IEA:Ensembl. DR GO; GO:0002741; P:positive regulation of cytokine secretion involved in immune response; IEA:Ensembl. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl. DR GO; GO:0035066; P:positive regulation of histone acetylation; IEA:Ensembl. DR GO; GO:0033129; P:positive regulation of histone phosphorylation; IEA:Ensembl. DR GO; GO:0010759; P:positive regulation of macrophage chemotaxis; IEA:Ensembl. DR GO; GO:1905050; P:positive regulation of metallopeptidase activity; IEA:Ensembl. DR GO; GO:0051973; P:positive regulation of telomerase activity; IEA:Ensembl. DR GO; GO:1904355; P:positive regulation of telomere capping; IEA:Ensembl. DR GO; GO:0032212; P:positive regulation of telomere maintenance via telomerase; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl. DR GO; GO:1904417; P:positive regulation of xenophagy; IEA:Ensembl. DR GO; GO:0030641; P:regulation of cellular pH; IEA:Ensembl. DR GO; GO:0051090; P:regulation of DNA binding transcription factor activity; IEA:Ensembl. DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central. DR GO; GO:0030278; P:regulation of ossification; IEA:Ensembl. DR GO; GO:0070849; P:response to epidermal growth factor; IEA:Ensembl. DR GO; GO:0043330; P:response to exogenous dsRNA; IEA:Ensembl. DR GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl. DR GO; GO:0051403; P:stress-activated MAPK cascade; IEA:Ensembl. DR GO; GO:0048538; P:thymus development; IEA:Ensembl. DR GO; GO:0030878; P:thyroid gland development; IEA:Ensembl. DR GO; GO:0060440; P:trachea formation; IEA:Ensembl. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:Ensembl. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR003527; MAP_kinase_CS. DR InterPro; IPR008349; MAPK_ERK1/2. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR Pfam; PF00069; Pkinase; 1. DR PRINTS; PR01770; ERK1ERK2MAPK. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF56112; SSF56112; 1. DR PROSITE; PS01351; MAPK; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|SAAS:SAAS00652810}; KW Complete proteome {ECO:0000313|Proteomes:UP000011712}; KW Kinase {ECO:0000256|SAAS:SAAS00652820}; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS00652804}; KW Reference proteome {ECO:0000313|Proteomes:UP000011712}; KW Serine/threonine-protein kinase {ECO:0000256|SAAS:SAAS00652809}; KW Transferase {ECO:0000256|SAAS:SAAS00652816}. SQ SEQUENCE 295 AA; 34115 MW; C25659F205AC1D93 CRC64; GPLSSAYDHV RKTRVAIKKI SPFEHQTYCQ RTLREIQILL RFRHENVIGI RDILRAPTLE AMRDVYIVQD LMETDLYKLL KSQQLSNDHI CYFLYQILRA NVLHRDLKPS NLLINTTCDL KICDFGLARI ADPEHDHTGF LTEYVATRWY RAPEIMLNSK VKGRTLKKAP ALPTGILGSP SQEDLNCIIN MKARNYLQSL PSKTKVAWAK LFPKSDAKAL DLLDRMLTFN PNKRITVEEA LAHPYLEQYY DPTDEPVAEE PFTFDMELDD LPKERLKELI FQETARFQPG ALEAP //