ID M3WK78_FELCA Unreviewed; 372 AA. AC M3WK78; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 16-MAR-2016, entry version 26. DE RecName: Full=Mitogen-activated protein kinase {ECO:0000256|SAAS:SAAS00388444}; DE EC=2.7.11.24 {ECO:0000256|SAAS:SAAS00388444}; DE Flags: Fragment; GN Name=MAPK3 {ECO:0000313|Ensembl:ENSFCAP00000013148}; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000013148, ECO:0000313|Proteomes:UP000011712}; RN [1] {ECO:0000313|Ensembl:ENSFCAP00000013148, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013148, RC ECO:0000313|Proteomes:UP000011712}; RX PubMed=17975172; DOI=10.1101/gr.6380007; RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., RA Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., RA Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N., RA Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.; RT "Initial sequence and comparative analysis of SAA cat genome."; RL Genome Res. 17:1675-1689(2007). RN [2] {ECO:0000313|Ensembl:ENSFCAP00000013148} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013148}; RA Hillier L.W., Warren W., Obrien S., Wilson R.K.; RT "Sequence assembly of the Felis catus genome version 6.2."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSFCAP00000013148} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013148}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. CC {ECO:0000256|SAAS:SAAS00095926}. CC -!- SIMILARITY: Contains protein kinase domain. CC {ECO:0000256|SAAS:SAAS00095951}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000013148}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AANG02018170; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG02018171; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG02018172; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9685.ENSFCAP00000013148; -. DR Ensembl; ENSFCAT00000014177; ENSFCAP00000013148; ENSFCAG00000014173. DR eggNOG; KOG0660; Eukaryota. DR eggNOG; ENOG410XNY0; LUCA. DR GeneTree; ENSGT00550000074298; -. DR InParanoid; M3WK78; -. DR OMA; PRYTDLQ; -. DR OrthoDB; EOG7M3J0K; -. DR Proteomes; UP000011712; Chromosome E3. DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl. DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl. DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl. DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl. DR GO; GO:0031143; C:pseudopodium; IEA:Ensembl. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004707; F:MAP kinase activity; IEA:UniProtKB-EC. DR GO; GO:0060020; P:Bergmann glial cell differentiation; IEA:Ensembl. DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl. DR GO; GO:0061308; P:cardiac neural crest cell development involved in heart development; IEA:Ensembl. DR GO; GO:0051216; P:cartilage development; IEA:Ensembl. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0006975; P:DNA damage induced protein phosphorylation; IEA:Ensembl. DR GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl. DR GO; GO:0060324; P:face development; IEA:Ensembl. DR GO; GO:0070498; P:interleukin-1-mediated signaling pathway; IEA:Ensembl. DR GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl. DR GO; GO:0060425; P:lung morphogenesis; IEA:Ensembl. DR GO; GO:2000657; P:negative regulation of apolipoprotein binding; IEA:Ensembl. DR GO; GO:0042473; P:outer ear morphogenesis; IEA:Ensembl. DR GO; GO:0038083; P:peptidyl-tyrosine autophosphorylation; IEA:Ensembl. DR GO; GO:0031281; P:positive regulation of cyclase activity; IEA:Ensembl. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl. DR GO; GO:0035066; P:positive regulation of histone acetylation; IEA:Ensembl. DR GO; GO:0033129; P:positive regulation of histone phosphorylation; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl. DR GO; GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IEA:Ensembl. DR GO; GO:0070849; P:response to epidermal growth factor; IEA:Ensembl. DR GO; GO:0043330; P:response to exogenous dsRNA; IEA:Ensembl. DR GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl. DR GO; GO:0048538; P:thymus development; IEA:Ensembl. DR GO; GO:0030878; P:thyroid gland development; IEA:Ensembl. DR GO; GO:0060440; P:trachea formation; IEA:Ensembl. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:Ensembl. DR InterPro; IPR011009; Kinase-like_dom. DR InterPro; IPR003527; MAP_kinase_CS. DR InterPro; IPR008349; MAPK_ERK1/2. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR002290; Ser/Thr_dual-sp_kinase. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR Pfam; PF00069; Pkinase; 1. DR PRINTS; PR01770; ERK1ERK2MAPK. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF56112; SSF56112; 1. DR PROSITE; PS01351; MAPK; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|SAAS:SAAS00465584}; KW Complete proteome {ECO:0000313|Proteomes:UP000011712}; KW Kinase {ECO:0000256|SAAS:SAAS00465575}; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS00465633}; KW Reference proteome {ECO:0000313|Proteomes:UP000011712}; KW Serine/threonine-protein kinase {ECO:0000256|SAAS:SAAS00465625}; KW Transferase {ECO:0000256|SAAS:SAAS00465635}. FT DOMAIN 35 323 Protein kinase. {ECO:0000259|PROSITE: FT PS50011}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSFCAP00000013148}. SQ SEQUENCE 372 AA; 42827 MW; D7EBF420B4DB0008 CRC64; SRKEPALFLG QNPLLLPPLP AQAWVGPPGL DSPYVRPHRQ HLSGPLSSAY DHVRKTRVAI KKISPFEHQT YCQRTLREIQ ILLRFRHENV IGIRDILRAP TLEAMRDDSP DYIVQDLMET DLYKLLKSQQ LSNDHICYFL YQILRGLKYI HSANVLHRDL KPSNLLINTT CDLKICDFGL ARIADPEHDH TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI LGILGSPSQE DLNCIINMKA RNYLQSLPSK TKVAWAKLFP KSDAKALDLL DRMLTFNPNK RITVEEALAH PYLEQYYDPT DEPVAEEPFT FDMELDDLPK ERLKELIFQE TARFQPGALE AP //