ID M3WK78_FELCA Unreviewed; 372 AA. AC M3WK78; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 17-FEB-2016, entry version 25. DE RecName: Full=Mitogen-activated protein kinase {ECO:0000256|SAAS:SAAS00388444}; DE EC=2.7.11.24 {ECO:0000256|SAAS:SAAS00388444}; DE Flags: Fragment; GN Name=MAPK3 {ECO:0000313|Ensembl:ENSFCAP00000013148}; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000013148, ECO:0000313|Proteomes:UP000011712}; RN [1] {ECO:0000313|Ensembl:ENSFCAP00000013148, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013148, RC ECO:0000313|Proteomes:UP000011712}; RX PubMed=17975172; DOI=10.1101/gr.6380007; RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., RA Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., RA Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N., RA Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.; RT "Initial sequence and comparative analysis of SAA cat genome."; RL Genome Res. 17:1675-1689(2007). RN [2] {ECO:0000313|Ensembl:ENSFCAP00000013148} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013148}; RA Hillier L.W., Warren W., Obrien S., Wilson R.K.; RT "Sequence assembly of the Felis catus genome version 6.2."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSFCAP00000013148} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013148}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. CC {ECO:0000256|SAAS:SAAS00095926}. CC -!- SIMILARITY: Contains protein kinase domain. CC {ECO:0000256|SAAS:SAAS00095951}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000013148}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AANG02018170; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG02018171; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG02018172; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9685.ENSFCAP00000013148; -. DR Ensembl; ENSFCAT00000014177; ENSFCAP00000013148; ENSFCAG00000014173. DR eggNOG; ENOG410XNY0; LUCA. DR eggNOG; KOG0660; Eukaryota. DR GeneTree; ENSGT00550000074298; -. DR InParanoid; M3WK78; -. DR OMA; PRYTDLQ; -. DR OrthoDB; EOG7M3J0K; -. DR Proteomes; UP000011712; Chromosome E3. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004707; F:MAP kinase activity; IEA:UniProtKB-EC. DR InterPro; IPR011009; Kinase-like_dom. DR InterPro; IPR003527; MAP_kinase_CS. DR InterPro; IPR008349; MAPK_ERK1/2. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR002290; Ser/Thr_dual-sp_kinase. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR Pfam; PF00069; Pkinase; 1. DR PRINTS; PR01770; ERK1ERK2MAPK. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF56112; SSF56112; 1. DR PROSITE; PS01351; MAPK; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|SAAS:SAAS00465584}; KW Complete proteome {ECO:0000313|Proteomes:UP000011712}; KW Kinase {ECO:0000256|SAAS:SAAS00465575}; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS00465633}; KW Reference proteome {ECO:0000313|Proteomes:UP000011712}; KW Serine/threonine-protein kinase {ECO:0000256|SAAS:SAAS00465625}; KW Transferase {ECO:0000256|SAAS:SAAS00465635}. FT DOMAIN 35 323 Protein kinase. {ECO:0000259|PROSITE: FT PS50011}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSFCAP00000013148}. SQ SEQUENCE 372 AA; 42827 MW; D7EBF420B4DB0008 CRC64; SRKEPALFLG QNPLLLPPLP AQAWVGPPGL DSPYVRPHRQ HLSGPLSSAY DHVRKTRVAI KKISPFEHQT YCQRTLREIQ ILLRFRHENV IGIRDILRAP TLEAMRDDSP DYIVQDLMET DLYKLLKSQQ LSNDHICYFL YQILRGLKYI HSANVLHRDL KPSNLLINTT CDLKICDFGL ARIADPEHDH TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI LGILGSPSQE DLNCIINMKA RNYLQSLPSK TKVAWAKLFP KSDAKALDLL DRMLTFNPNK RITVEEALAH PYLEQYYDPT DEPVAEEPFT FDMELDDLPK ERLKELIFQE TARFQPGALE AP //