ID M3WK78_FELCA Unreviewed; 372 AA. AC M3WK78; DT 01-MAY-2013, integrated into UniProtKB/TrEMBL. DT 01-MAY-2013, sequence version 1. DT 07-JAN-2015, entry version 15. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFCAP00000013148}; DE Flags: Fragment; GN Name=MAPK3 {ECO:0000313|Ensembl:ENSFCAP00000013148}; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000013148, ECO:0000313|Proteomes:UP000011712}; RN [1] {ECO:0000313|Ensembl:ENSFCAP00000013148, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013148, RC ECO:0000313|Proteomes:UP000011712}; RX PubMed=17975172; DOI=10.1101/gr.6380007; RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S., RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., RA Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U., RA Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N., RA Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.; RT "Initial sequence and comparative analysis of SAA cat genome."; RL Genome Res. 17:1675-1689(2007). RN [2] {ECO:0000313|Ensembl:ENSFCAP00000013148, ECO:0000313|Proteomes:UP000011712} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013148, RC ECO:0000313|Proteomes:UP000011712}; RA Hillier L.W., Warren W., Obrien S., Wilson R.K.; RT "Sequence assembly of the Felis catus genome version 6.2."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSFCAP00000013148} RP IDENTIFICATION. RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013148}; RG Ensembl; RL Submitted (MAR-2013) to UniProtKB. CC -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. CC {ECO:0000256|SAAS:SAAS00095926}. CC -!- SIMILARITY: Contains protein kinase domain. CC {ECO:0000256|SAAS:SAAS00095951}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000013148}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AANG02018170; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG02018171; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AANG02018172; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSFCAT00000014177; ENSFCAP00000013148; ENSFCAG00000014173. DR GeneTree; ENSGT00550000074298; -. DR InParanoid; M3WK78; -. DR OMA; GPRYTDL; -. DR OrthoDB; EOG7M3J0K; -. DR Proteomes; UP000011712; Chromosome E3. DR GO; GO:0005829; C:cytosol; IEA:Ensembl. DR GO; GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl. DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl. DR GO; GO:0005634; C:nucleus; IEA:Ensembl. DR GO; GO:0031143; C:pseudopodium; IEA:Ensembl. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004707; F:MAP kinase activity; IEA:InterPro. DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl. DR GO; GO:0051216; P:cartilage development; IEA:Ensembl. DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl. DR GO; GO:0006975; P:DNA damage induced protein phosphorylation; IEA:Ensembl. DR GO; GO:0070498; P:interleukin-1-mediated signaling pathway; IEA:Ensembl. DR GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl. DR GO; GO:2000657; P:negative regulation of apolipoprotein binding; IEA:Ensembl. DR GO; GO:0009887; P:organ morphogenesis; IEA:Ensembl. DR GO; GO:0038083; P:peptidyl-tyrosine autophosphorylation; IEA:Ensembl. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl. DR GO; GO:0035066; P:positive regulation of histone acetylation; IEA:Ensembl. DR GO; GO:0033129; P:positive regulation of histone phosphorylation; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl. DR GO; GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IEA:Ensembl. DR GO; GO:0070849; P:response to epidermal growth factor; IEA:Ensembl. DR GO; GO:0043330; P:response to exogenous dsRNA; IEA:Ensembl. DR GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:Ensembl. DR InterPro; IPR011009; Kinase-like_dom. DR InterPro; IPR003527; MAP_kinase_CS. DR InterPro; IPR008349; MAPK_ERK1/2. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR002290; Ser/Thr_dual-sp_kinase. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR Pfam; PF00069; Pkinase; 1. DR PRINTS; PR01770; ERK1ERK2MAPK. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF56112; SSF56112; 1. DR PROSITE; PS01351; MAPK; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|SAAS:SAAS00095922}; KW Complete proteome {ECO:0000313|Proteomes:UP000011712}; KW Kinase {ECO:0000256|SAAS:SAAS00095911}; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS00095948}; KW Reference proteome {ECO:0000313|Proteomes:UP000011712}; KW Serine/threonine-protein kinase {ECO:0000256|SAAS:SAAS00095939}; KW Transferase {ECO:0000256|SAAS:SAAS00095933}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSFCAP00000013148}. SQ SEQUENCE 372 AA; 42827 MW; D7EBF420B4DB0008 CRC64; SRKEPALFLG QNPLLLPPLP AQAWVGPPGL DSPYVRPHRQ HLSGPLSSAY DHVRKTRVAI KKISPFEHQT YCQRTLREIQ ILLRFRHENV IGIRDILRAP TLEAMRDDSP DYIVQDLMET DLYKLLKSQQ LSNDHICYFL YQILRGLKYI HSANVLHRDL KPSNLLINTT CDLKICDFGL ARIADPEHDH TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI LGILGSPSQE DLNCIINMKA RNYLQSLPSK TKVAWAKLFP KSDAKALDLL DRMLTFNPNK RITVEEALAH PYLEQYYDPT DEPVAEEPFT FDMELDDLPK ERLKELIFQE TARFQPGALE AP //